Degradable biliary duct drug-eluting stent

A bile duct stent and drug delivery technology, applied in the direction of bile duct, medical science, and human tubular structure devices, can solve problems such as bleeding, incomplete degradation of plastic inner tubes, and bile duct damage, achieve good therapeutic effects, avoid foreign body stimulation, The effect of preventing restenosis

Inactive Publication Date: 2017-04-26
SHANGHAI XUHUI DISTRICT DAHUA HOSPITAL
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0007] Both plastic inner tubes and metal stents cannot be completely degraded when used as biliary stents, and need to be removed after treatment, which can easily cause biliary tract damage and induce bleeding

Method used

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  • Degradable biliary duct drug-eluting stent
  • Degradable biliary duct drug-eluting stent
  • Degradable biliary duct drug-eluting stent

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0037] Example 1: A degradable bile duct stent covered with a membrane for drug delivery, which is woven into the body of the degradable bile duct stent by mixing magnesium alloy silk thread and polydioxanone (PDO) silk thread, and further uses electrospinning technology on the surface of the bile duct stent body , A nanofiber membrane coated with polycaprolactone-paclitaxel drug, the membrane has the characteristics of slow drug release, and does not affect the original mechanical properties of the stent. In addition, the membrane is also a degradable polymer carrier, so a Fully degradable bile duct stent covered with drug delivery. The bile duct stent body has a tubular structure, both ends of the bile duct stent body are flared outwardly, and the surface of the bile duct stent body is grid-shaped.

Embodiment 2

[0038] Example 2: A degradable bile duct stent covered with a membrane for drug delivery, which is woven into the body of the degradable bile duct stent with a mixture of magnesium alloy silk thread and polydioxanone (PDO) silk thread, and further electrospinning technology is used on the surface of the bile duct stent body , A nanofiber membrane covered with polytrimethylene carbonate-paclitaxel drug. The membrane has the characteristics of slow release of the drug and does not affect the original mechanical properties of the stent. In addition, the membrane is also a degradable polymer carrier, so it is constructed A fully degradable bile duct stent covered with drug delivery. The bile duct stent body has a tubular structure, both ends of the bile duct stent body are flared outwardly, and the surface of the bile duct stent body is grid-shaped.

Embodiment 3

[0039] Example 3: A degradable bile duct stent covered with a membrane for drug delivery, which is woven into the body of the degradable bile duct stent with a mixture of magnesium alloy silk thread and polydioxanone (PDO) silk thread, and further electrospinning technology is used on the surface of the bile duct stent body , The nanofiber membrane coated with polycaprolactone-sirolimus drug, the membrane has the characteristics of slow release of the drug, and does not affect the original mechanical properties of the stent. In addition, the membrane is also a degradable polymer carrier, so A fully degradable bile duct stent covered with drug delivery was constructed. The bile duct stent body has a tubular structure, both ends of the bile duct stent body are flared outwardly, and the surface of the bile duct stent body is grid-shaped.

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PUM

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Abstract

The invention discloses a degradable biliary duct drug-eluting stent, which consists of a biliary duct stent body and a biodegradable high-molecular polymer coating arranged on the surface of the biliary duct stent body. The biliary duct stent body is formed by mixed braiding of biodegradable metal wires and biodegradable high-molecular material silk threads. The biliary duct stent body is of a tubular structure. The two ends of the biliary duct stent body are shaped like trumpets that are open outwardly. The surface of the biliary duct stent body is a netted surface. The biodegradable high-molecular polymer coating carries drugs. The degradable biliary duct drug-eluting stent plays a mechanical supporting effect in a short period, is completely degraded after a treatment effect disappears, prevents tube wall tissues from being stimulated for a long period of time, effectively prevents the wall tissues from narrowing again after an operation, enables drug loaded fiber films to evenly wrap the surface of the stent body, and makes the drugs release slowly.

Description

Technical field [0001] The invention relates to a bile duct stent, in particular to a degradable bile duct stent with membrane covering and drug delivery. Background technique [0002] Benign bile duct stenosis is a common clinical benign biliary system disease, which mainly occurs after cholecystectomy, liver transplantation, chronic pancreatitis, pancreatic pseudocyst, common bile duct stones, sclerosing cholangitis, and other related biliary diseases . After bile duct injury, scar formation is the most basic pathological change. The main complications of benign bile duct stricture include liver function enzyme changes, obstructive jaundice, recurrent cholangitis, secondary biliary cirrhosis, etc., in order to prevent complications The occurrence of this disease requires early appropriate and effective treatment. Bile duct stent placement can relieve esophageal stenosis and obstruction caused by benign and malignant bile duct lesions, and effectively relieve the clinical symp...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61F2/04
CPCA61F2/04A61F2/0077A61F2002/041A61F2210/0004A61F2230/0002A61F2250/0067
Inventor 曹军崔文国苑天文朱悦琦
Owner SHANGHAI XUHUI DISTRICT DAHUA HOSPITAL
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