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Vaginal plug film with micrometer holes

A vaginal plug and hole technology, which is applied in the field of preparation of vaginal plug membrane, can solve the problems of hard texture, low bioabsorbability and poor moisturizing property of vaginal membrane preparation, and achieves the effect of relieving inflammation symptoms

Inactive Publication Date: 2017-04-26
香港和和有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0007] One purpose of the present invention is to propose a novel vaginal plug film, which can solve the problems of hard texture, poor moisture retention, and low bioabsorbability of currently commercially available vaginal films.

Method used

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  • Vaginal plug film with micrometer holes
  • Vaginal plug film with micrometer holes
  • Vaginal plug film with micrometer holes

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0031] "Example 1: Preparation of Cortex Phellodendron Extract-Carboxymethyl Cellulose"

[0032]The preparation of amurberry extract-carboxymethyl cellulose is improved from the method described in the document Med Princ Pract.2006; 15(5):373-8, and the amurberry bark extract containing high concentration of berberine is referred to the same document obtained. After drying the residue and grinding the residue into powder, immerse the powder in 5% sodium hydroxide solution for about 2 hours at room temperature, then immerse the powder in 10% sodium hydroxide solution and heat to 90°C. Keep warm for about 4 hours. Afterwards, the obtained substrate is decolorized with a solution of sodium hypochlorite (NaClO) and hydrogen peroxide at a weight ratio of 3:4, and then the decolorized substrate is washed with water. Next, dry the matrix with a suction filter for about 2 hours. After alkalizing the substrate at 30°C for about 60 minutes, the substrate was etherified with 85% ethan...

Embodiment 2

[0033] "Example 2: Preparation of thin film"

[0034] Use a magnetic stirrer to uniformly mix the aforementioned Phellodendron amurense extract-carboxymethyl cellulose powder, sodium hyaluronate, polyvinyl alcohol, Tween-80, and such as sapindus seed oil, olive oil, almond oil, or avocado oil and other vegetable oils or water to form a mixture of micron-sized oil droplet particles or water droplet particles that contain vegetable oil or water and pass through Tween-80. Take 3mL of the mixture into a circular mold (diameter: about 60mm, depth: about 15mm). Finally, the mold was placed in an oven at 37° C. for about 3 hours to form a dry film (hereinafter referred to as “corkberry extract-carboxymethylcellulose / hyaluronic acid porous film”). In addition, another dry film, hereinafter referred to as "carboxymethylcellulose / hyaluronic acid porous film" was prepared. The dry film was prepared as described above, except that commercially available carboxymethyl cellulose was subst...

Embodiment 3

[0035] "Example 3: Detection of Berberine"

[0036] The concentration of berberine was measured in a NanoDrop UV-Vis spectrophotometer with light at a wavelength of 260nm. For details, please refer to Photochem Photobiol Sci.2009Jul;8(7):970-4. The calibration curve of the berberine standard was obtained by selecting six concentration points with R values ​​greater than 0.99 from 37.25 to 1000 μg / mL. Before measurement, the film was dissolved in double distilled water so that the resulting solution had a concentration of 500 μg / mL. The berberine content released from the test films was calculated from the calibration curve.

[0037] like Figure 1A As shown, the ultraviolet-visible light spectrum of the standard product has two strong peaks at about 250nm and 350nm, and one weak peak at about 430nm. In addition, the spectral pattern of Phellodendron bark extract is similar to that of the standard product, and there are also two strong peaks at about the same position, while ...

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Abstract

The invention provides a use of a film in the production of a vaginal plug film. The film has a plurality of holes with the diameter of 5-100 [mu]m, and also comprises carboxymethyl cellulose and hyaluronic acid. The water retention property of the film makes the vaginal plug film have good water retention, so the vaginal plug film is placed in the vagina to keep the moisture of the vagina. Additionally, the high ductility and the flexibility of the film make the vaginal plug film placed in the vagina after being kneaded to form a ball have no damages to the vulva or the vagina. The holes increase the surface area of the film, so the vaginal plug film has increased contact with liquid when placed in the vagina in order to improve the absorption and the effect of effective components. The high biological absorption property of the film makes the vaginal plug film in the vagina autologously absorbed. The anti-inflammatory characteristic of the film makes the vaginal plug film placed in the vagina to alleviate inflammation symptoms.

Description

[0001] 【Technical field】 [0002] The present invention relates to a medical material application of a film containing carboxymethyl cellulose (CMC) and hyaluronic acid (hyaluronic acid, HA), and particularly relates to a use of the film for preparing a vaginal plug . [0003] 【Background technique】 [0004] Traditionally, when women use vaginal film, they must first knead the film into a ball, and then insert the film into the vagina. Through the active ingredients in the vaginal film, relieve discomfort such as dryness, itching, redness, pain, or burning caused by vaginal inflammation. The currently commercially available vaginal film can refer to the "Baofukang vaginal film" described in the Chinese Mainland Invention Patent Publication No. CN1650961, which is made of raw materials and auxiliary materials, and the raw materials use curcuma oil and borneol as active ingredients , and add film-forming materials, antioxidants, humectants, and plasticizers and other auxiliary ...

Claims

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Application Information

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IPC IPC(8): A61K9/70A61K47/38A61K47/36A61K31/4375A61K36/756A61P15/02A61P31/04A61P31/10A61P33/02
CPCA61K9/7007A61K9/0034A61K31/4375A61K36/756A61K47/36A61K47/38
Inventor 黄俞智叶孟莹黄琨裕黄豪铭徐和
Owner 香港和和有限公司
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