A kind of myricetin extract, the pharmaceutical composition containing it and its use

A technology of extract and myricetin, which is applied in the pharmaceutical field, can solve unseen problems, achieve the effect of relieving side effects, ensuring biological activity, and broad clinical application prospects
CN106581090BActive Publication Date: 2021-01-12BEIJING NORMAL UNIVERSITY
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Patents(China)
Current Assignee / Owner
BEIJING NORMAL UNIVERSITY
Publication Date
2021-01-12

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Abstract

A myricetin extract, prepared by an extraction method comprising the following steps: (1) plants of Myricaceae, Grape, Leguminosae or Camelliaceae are crushed, degreased and then dissolved in a methanol aqueous solution, and extracted by microwave and ultra-sonication to obtain an extract solution; (2) the extract solution obtained in step (1) is concentrated under a reduced pressure to obtain a concentrated solution, which is then filtrated under a reduced pressure and extracted with trichloromethane, and the resulting extract solution is collected, freeze-dried and pulverized; (3) a powder obtained in step (2) is dissolved in petroleum ether and then purified by means of silica gel column, so as to collect an eluate containing myricetin, which is then concentrated to obtain a crude product of myricetin; (4) the crude product of myricetin obtained in step (3) is added to a methanol aqueous solution having a volume ratio of 50-75%, and is heated to 75-80ºC till completely dissolved and then stirred, the extract is obtained following cooling and standing, crystallizing, filtrating and drying. The myricetin extract is used to prevent or treat tumor metastasis.
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Description

technical field

[0001] The invention belongs to the technical field of pharmacy. Specifically, the present invention relates to the myricetin extract extracted from plants, the pharmaceutical composition containing it and its preparation for preventing and / or treating diseases caused by tumor metastasis or for inhibiting tumor cell migration. use in . Background technique

[0002] According to the latest report of the International Cancer Research Center (IARC), cancer patients worldwide are increasing at an average annual rate of 3%-5%, and cancer has become the largest public health problem in the world. According to the report of the World Health Organization, about 80% of cancer patients worldwide died of recurrence and metastasis after surgery, radiotherapy and chemotherapy. According to data from the American Cancer Society in 2015, the overall 5-year survival rate of patients after tumor metastasis is much lower than that of primary cancer. Survival rate. The terrib...

Claims

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