Fluorescent probe capable of separately detecting cysteine/homocysteine, glutathione and sulfuretted hydrogen and preparation method and application of fluorescent probe

A homocysteine ​​and glutathione technology, applied in chemical instruments and methods, fluorescence/phosphorescence, analytical materials, etc., can solve the problems of indistinguishable detection and achieve high yield and simple synthesis
CN106588912AInactive Publication Date: 2017-04-26UNIV OF JINAN
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
UNIV OF JINAN
Publication Date
2017-04-26
Estimated Expiration
Not applicable · inactive patent

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Abstract

The invention discloses a fluorescent probe capable of separately detecting cysteine / homocysteine, glutathione and sulfuretted hydrogen and a preparation method and application of the fluorescent probe. The molecular formula of the probe is C38H28IN5O5S, and the structural formula is shown in the description. The probe is simple to synthesize, higher in yield, can separately detect Cys / Hcy, GSH and H2S in a water solution, and can separately detect Cys / Hcy, GSH and H2S in the living cell level.
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Description

technical field

[0001] The invention relates to a fluorescent probe for distinguishing and detecting cysteine / homocysteine, glutathione and hydrogen sulfide based on a multi-signal mode, a preparation method and an application thereof, and belongs to the technical field of analytical chemistry. Background technique

[0002] Reactive sulfur species (RSS), including small molecular biothiols (Thiols) and gaseous molecular hydrogen sulfide (H 2 S), is a class of biologically active molecules that play an important physiological role in the human body. Cysteine ​​(Cys), homocysteine ​​(Hcy) and glutathione (GSH) are the three most common small molecule biothiols, however, they have distinct biological and pharmacological effects and interact with each other at the same time. There is also a close relationship between them. Cys is the precursor of acetyl coenzyme, taurine and GSH, and can also form sulfur-iron complexes with iron ions, but abnormal levels of Cys usually cause s...

Claims

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