Zn-ZnO zinc alloy and its preparation method and application

A technology of zinc alloy and mixture, which is applied in Zn-ZnO series zinc alloy and its preparation, and in the field of preparation of biodegradable medical implants, to achieve excellent antibacterial properties, inhibit smooth muscle cell proliferation, and controllable blood compatibility

Active Publication Date: 2017-05-03
PEKING UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

There are no literature and patent reports on the preparation and properties of Zn-ZnO zinc alloys at home and abroad, and it is proposed to use Zn-ZnO zinc alloys as biodegradable biomedical materials

Method used

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  • Zn-ZnO zinc alloy and its preparation method and application
  • Zn-ZnO zinc alloy and its preparation method and application
  • Zn-ZnO zinc alloy and its preparation method and application

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0084] Embodiment 1, preparation Zn-ZnO series zinc alloy:

[0085]1) Using pure Zn powder (purity 99.9%, particle size 45-109 μm) (purchased from Alfa Aesar), ZnO powder (purity 99.9%, particle size <5 μm) (purchased from Sigma-Aldrich) as raw materials, according to different mass ratios (The mass ratio of Zn to ZnO is 99.75:0.25, 99.5:0.5, 99:1, 95:5, 90:10) in a vacuum glove box, put into a vacuum ball mill jar under the protection of argon, and pass through a planetary ball mill Mix evenly, ball milling speed 200rpm, ball to material ratio 20:1, ball milling time 60min, get a uniform mixture with different mass ratios of Zn and ZnO, store in an argon protective atmosphere to prevent oxidation;

[0086] 2) Put the homogeneous mixture in step 1) into the graphite abrasive tool, pressurize axially and sinter by spark plasma vacuum: the initial sintering pressure is 1MPa, the heat preservation sintering pressure is 60MPa, firstly the temperature is raised to 250℃ at 100℃ / min,...

Embodiment 2

[0087] Embodiment 2, preparation is coated with the Zn-ZnO series zinc alloy of ceramic coating:

[0088] 1) Using pure Zn powder (purity 99.9%, particle size 45-109 μm) (purchased from Alfa Aesar), ZnO powder (purity 99.9%, particle size <5 μm) (purchased from Sigma-Aldrich) as raw materials, according to different mass ratios (The mass ratio of Zn to ZnO is 99.75:0.25, 99.5:0.5, 99:1, 95:5, 90:10) in a vacuum glove box, put into a vacuum ball mill jar under the protection of argon, and pass through a planetary ball mill Mix evenly, ball milling speed 200rpm, ball to material ratio 20:1, ball milling time 60min, get a uniform mixture with different mass ratios of Zn and ZnO, store in an argon protective atmosphere to prevent oxidation;

[0089] 2) Put the homogeneous mixture in step 1) into the graphite abrasive tool, pressurize axially and sinter by spark plasma vacuum: the initial sintering pressure is 1MPa, the heat preservation sintering pressure is 60MPa, firstly the tem...

Embodiment 3

[0091] Embodiment 3, Zn-ZnO system zinc alloy microstructural analysis:

[0092] The Zn-ZnO series zinc alloy in Example 1 was prepared by wire cutting to prepare a 10×10×1mm sample, which was sequentially ground and polished by 400#, 800#, 1200# and 2000# SiC sandpaper series. After ultrasonic cleaning in acetone, absolute ethanol and deionized water for 15 min, dry at 25 °C. The sample was subjected to X-ray diffraction analysis, etched with 4% nitric acid alcohol for 5-30 seconds, washed with deionized water, dried, observed under a metallographic microscope, and tested for density by a densitometer.

[0093] figure 1 It is Zn-ZnO series zinc alloy metallurgy, from figure 1 It can be seen that: ZnO is evenly distributed on the boundary of pure Zn particles, and with the increase of ZnO content, ZnO on the boundary begins to aggregate, which breaks the bond between pure zinc particles.

[0094] figure 2 It is the X-ray diffraction analysis diagram of Zn-ZnO zinc alloy, ...

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Abstract

The invention discloses a Zn-ZnO zinc alloy and its preparation method and application. The zinc alloy comprises Zn and ZnO, and the mass percentage of ZnO in the zinc alloy is greater than 0 and less than or equal to 10%. The zinc alloy also comprises trace elements comprising one or more of silicon, phosphorus, lithium, silver, tin and rare earth elements, and the mass percentage of the trace elements is greater than 0 and less than or equal to 3%. Mechanical properties of the Zn-ZnO zinc alloy satisfy requirements of the strength and toughness of the medical implant material. The Zn-ZnO zinc alloy has no cytotoxicity to the endothelial cells and osteoblasts, can inhibit the proliferation of smooth muscle cells, has good histocompatibility and blood compatibility, and can adjust and control the degradation of the body fluid. The dissolved metal ions can be absorbed and used by organisms or be metabolized and excreted, has excellent antibacterial properties and can be used for preparation of medical implants.

Description

technical field [0001] The invention belongs to the technical field of preparation of medical metal materials, and relates to a Zn-ZnO series zinc alloy and its preparation method and application, in particular to a Zn-ZnO series zinc alloy and its preparation method and its use in the preparation of body fluid degradable medical implants in the application. Background technique [0002] Biomedical materials are materials used to diagnose, treat, repair or replace diseased tissues and organs of living organisms or enhance their functions. It is the basis for the study of artificial organs and medical devices, and can be divided into repair materials, cardiovascular system materials, medical membrane materials, drug release carrier materials, biosensor materials, dental materials, etc. according to their uses. According to the composition and properties, there are mainly biomedical metal materials, bioceramics, biomedical polymers, biomedical composite materials and bio-deri...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L27/04A61L27/02A61L27/58A61L27/54A61L27/34A61L31/02A61L31/16A61L31/14A61L31/10A61K6/04A61K6/033A61K6/027C22C18/00C22C32/00C22C1/05A61K6/838
Inventor 郑玉峰杨宏韬成艳
Owner PEKING UNIV
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