Unlock instant, AI-driven research and patent intelligence for your innovation.

Arginine preparation and its preparation method and application

A technology of arginine and coating agent, applied in application, pill delivery, pharmaceutical formulation, etc., can solve the problems of unfavorable stable storage of arginine, poor compliance, etc., achieve high hardness, reduce cross-contamination, and the amount of auxiliary materials small effect

Active Publication Date: 2020-02-14
GUANGZHOU ZHONGDA NANSHA TECH INNOVATION IND PARK +1
View PDF6 Cites 0 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, arginine is highly hygroscopic, absorbs carbon dioxide from the air, and has a salty-bitter taste
Therefore, the existing form of arginine powder is not conducive to the stable preservation of arginine, and it has a salty and bitter taste when taken at the same time, and the compliance is not good

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Arginine preparation and its preparation method and application

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0044] Weigh 1500g of arginine, 15g of hydroxypropylmethylcellulose E5 / 2.5g of sucralose and 450g of purified water. Heat the purified water to 80°C, add the prescribed amount of hypromellose E5 and sucralose into the hot purified water while stirring to dissolve to obtain a coating solution, cool to room temperature, and set aside.

[0045] Add the prescribed amount of arginine powder into the multifunctional fluidized bed, set the preheating process parameters, the inlet air temperature is 60°C, and the fan air volume is 60m 3 / hr, preheating for 5 minutes. Load the coating liquid into the multifunctional fluidized bed, set the granulation process parameters of the multifunctional fluidized bed, and the air volume of the fan is 60m 3 / hr, air inlet temperature 60°C, atomization pressure 1.6kg / ㎡, liquid supply speed 40rpm, spray the coating liquid on the arginine powder at a uniform and constant speed to form coated particles, and dry at the same time, wait for moisture Aft...

Embodiment 2

[0047] Weigh 1500g of arginine, 15g of hydroxypropylmethylcellulose E15, 2.5g of sucralose and 450g of purified water. Heat the purified water to 80°C, add the prescribed amount of hypromellose E15 and sucralose into the hot purified water while stirring to dissolve to obtain a coating solution, cool to room temperature, and set aside.

[0048] Add the prescribed amount of arginine powder into the multifunctional fluidized bed, set the preheating process parameters, the inlet air temperature is 60°C, and the fan air volume is 60m 3 / hr, preheating for 5 minutes. Load the coating liquid into the multifunctional fluidized bed, set the granulation process parameters of the multifunctional fluidized bed, and the air volume of the fan is 60m 3 / hr, air inlet temperature 60°C, atomization pressure 1.6kg / ㎡, liquid supply speed 40rpm, spray the coating liquid on the arginine powder at a uniform and constant speed to form coated particles, and dry at the same time, wait for moisture ...

Embodiment 3

[0050] Weigh 1500g of arginine, 30g of high-substituted hydroxypropyl cellulose ELF, 2.5g of sucralose and 500g of purified water. Heat the purified water to 80°C, add the prescribed amount of highly substituted hydroxypropyl cellulose ELF and sucralose into the hot purified water while stirring to dissolve, disperse evenly to obtain a coating solution, cool to room temperature, and set aside.

[0051] Add the prescribed amount of arginine powder into the multifunctional fluidized bed, set the preheating process parameters, the inlet air temperature is 60°C, and the fan air volume is 60m 3 / hr, preheating for 5 minutes. Load the coating liquid into the multifunctional fluidized bed, set the granulation process parameters of the multifunctional fluidized bed, and the air volume of the fan is 60m 3 / hr, air inlet temperature 60°C, atomization pressure 1.6kg / ㎡, liquid supply speed 40rpm, spray the coating liquid on the arginine powder at a uniform and constant speed to form coat...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

PropertyMeasurementUnit
particle sizeaaaaaaaaaa
particle diameteraaaaaaaaaa
hardnessaaaaaaaaaa
Login to View More

Abstract

The invention relates to arginine particles. An outer layer of arginine powder is coated with a coating agent and a flavoring agent, so that the arginine powder can be effectively prevented from absorbing moisture, and salty and bitter taste of the arginine powder is screened; the arginine particles are small in the using amount of auxiliary materials, have high security and high compliance, and can be directly taken as a medicament or a nutritious supplement. Moreover, the arginine particles prepared by a fluidized bed granulation method have high hydrophilicity, high solubility, high robustness, high fluidity and high compressibility, are uniform and relatively centralized in particle size distribution, can be further prepared into other preparation forms, and can be taken as a medicament, a food and a health care product.

Description

technical field [0001] The invention belongs to the technical field of preparations, and in particular relates to an arginine preparation and its preparation method and application. Background technique [0002] Arginine is an α-amino acid, one of the 20 amino acids ubiquitous in nature. Arginine is classified as a semi-essential or conditionally essential amino acid in mammals, depending on the stage of development and health of the organism. The influence of arginine on the body is reflected in many aspects: [0003] (1) Arginine is a component in the ornithine cycle, which has extremely important physiological functions, mainly reflected in affecting the activity of arginase, which in turn affects the body's blood nitrogen and blood ammonia balance. For example, increasing the consumption of arginine can increase the activity of arginase in the liver, which helps to convert ammonia in the blood into urea and excrete it. Therefore, arginine has a certain effect on disea...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
Patent Type & Authority Patents(China)
IPC IPC(8): A61K9/50A61K9/20A61K31/198A61K47/38A61K47/36A61K47/42A61K47/10A61P3/02A23L33/175A23P10/30
CPCA23V2002/00A61K9/2059A61K9/2081A61K9/5036A61K9/5042A61K9/5057A61K31/198A23V2250/0606A23V2200/30
Inventor 吴传斌陈航平李革冯敏潘文杰杨思超胡春丽张林杰
Owner GUANGZHOU ZHONGDA NANSHA TECH INNOVATION IND PARK