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A thermosensitive vascular embolization material capable of long-term autoradiography and its preparation method

A vascular embolism and temperature-sensitive technology, which is applied in the field of long-term self-imaging temperature-sensitive vascular embolization materials and its preparation, can solve the problems of incomplete embedding, affecting the imaging effect, increasing the patient's physical injury and treatment costs, and achieving good embolization performance, good biocompatibility

Active Publication Date: 2019-11-01
HUAZHONG UNIV OF SCI & TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the embolic materials that have been used clinically at present basically use a temporary external developer, and the commonly used tantalum powder developer is likely to have the problem of incomplete embedding, which will affect the imaging effect; while the iodine-containing non-ionic After the operation, they are metabolized in a short time, and the re-injection of the contrast agent is required for angiographic diagnosis after the postoperative reexamination, which increases the physical harm to the patient and the cost of treatment

Method used

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  • A thermosensitive vascular embolization material capable of long-term autoradiography and its preparation method
  • A thermosensitive vascular embolization material capable of long-term autoradiography and its preparation method
  • A thermosensitive vascular embolization material capable of long-term autoradiography and its preparation method

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preparation example Construction

[0042] The invention provides a method for preparing a temperature-sensitive vascular embolism material capable of long-term autoradiography, comprising the following steps:

[0043] (1) After acrylamide compound, tert-butyl acrylate or its derivatives are mixed with organic solvent, liquid nitrogen freezing treatment is carried out;

[0044] (2) Under a protective atmosphere, the liquid nitrogen frozen material obtained in the step (1) is mixed with bis[2-(2'-bromoisobutyryloxy)ethyl]disulfide, ligand and copper system Catalyst mixing to carry out polymerization reaction;

[0045] (3) mixing the polymerization reaction product obtained in the step (2) with trifluoroacetic acid and an organic solvent, and performing a hydrolysis reaction to obtain a polyacrylamide polymer;

[0046] (4) The polyacrylamide polymer obtained in the step (3) is mixed with the gold nano-sol, and reacted under stirring conditions to obtain the gold nano-gel;

[0047] (5) mixing the gold nanogel obt...

Embodiment 1

[0090] 10mL of gold chlorate solution with a molar concentration of 100mmol / L was mixed with 92mL of ultrapure water, heated in an oil bath at 120°C under stirring at 800rpm, and 8mL of gold chlorate solution with a molar concentration of 49mmol / L (mass Concentration or molar concentration) sodium citrate solution, continue stirring reaction 15min, obtain gold nano sol.

[0091] The gold nano sol prepared in Example 1 was diluted with ultrapure water until the mass percentage concentration of the gold nanoparticles in the gold nano sol was 0.01%, as the sample to be tested; Nano-ZS90 laser particle size analyzer (Malvern, UK) was used company) to measure the average particle size of gold nanoparticles in the sample to be tested, the light source is a helium-neon laser (λ=633nm), and the detection angle is 90°. The experimental results show that the particle size of gold nanoparticles in the sample to be tested is 13±1 nm at 25° C.

Embodiment 2

[0093] Mix 10mL of gold chlorate solution with a molar concentration of 100mmol / L and 92mL of ultrapure water, stir at 700rpm, heat in an oil bath at 130°C, and add 8mL of gold chlorate solution with a molar concentration of 49mmol / L (mass concentration or molar concentration) sodium citrate solution, continue to stir and react for 30min to obtain gold nano sol.

[0094] The gold nano sol prepared in Example 1 was diluted with ultrapure water until the mass percent concentration of the gold nanoparticles in the gold nano sol was 0.1%, as the sample to be tested; Nano-ZS90 laser particle size analyzer (Malvern, UK) was used company) to measure the average particle size of gold nanoparticles in the sample to be tested, the light source is a helium-neon laser (λ=633nm), and the detection angle is 90°. The experimental results show that the particle size of gold nanoparticles in the sample to be tested is 15nm at 25°C.

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Abstract

The invention provides a temperature-sensitive vascular thrombosis material capable of performing long-term self-development and a preparation method thereof. The vascular thrombosis material contains gold nano gel and a dispersion medium, wherein the gold nano gel comprises a gold nano particle cytochalasin and a polyacrylamide amide compound temperature-sensitive polymer housing layer coated on the surface of the gold nano particle cytochalasin. The vascular thrombosis material only uses temperature as a phase change regulating and controlling factor, has good biocompatibility, can achieve long-term thrombosis in the blood vessel, has the capability of long-term development, can be used for vascular thrombosis of multiple tumor sites, achieves thrombosis of the aorta and terminal blood vessel, completely blocks blood and cuts off cancer cell blood supply to achieve the tumor suppression purpose.

Description

technical field [0001] The invention relates to the technical field of medical materials, in particular to a long-term autoradiographic temperature-sensitive vascular embolization material and a preparation method thereof. Background technique [0002] Chemoembolization is currently an important way to treat tumors. Embolization materials are selectively injected into the blood vessels supplying a certain tumor through a catheter, so that the corresponding blood vessels are occluded and the blood supply is interrupted to achieve the purpose of treatment. According to the statistics of the Barcelona Clinic Liver Cancer (BCLC) classification, tumor chemoembolization for liver cancer has a good therapeutic effect on more than 50% of the patients. [0003] An ideal vascular embolization material should have good fluidity, high vascular embolism strength, high-definition imaging and good biological safety. A variety of embolic materials have been developed so far, including gran...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61L24/06A61L24/02C08F8/12C08F220/54C08F220/18
CPCA61L24/001A61L24/0031A61L24/02A61L24/06A61L2430/36C08F8/12C08F220/54C08L33/26C08F220/1804
Inventor 赵彦兵彭晓乐杨祥良郑传胜刘一鸣
Owner HUAZHONG UNIV OF SCI & TECH
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