Phenylboronic acid modified magnetic nanoparticle, and preparation method and application thereof

A magnetic nanoparticle and nanoparticle technology, applied in the field of nanomaterials, can solve the problems of high material consumption and energy consumption, limited fructose, cumbersome process, etc., and achieve the effect of rapid separation, good repeatability, and optimized synthesis steps

Active Publication Date: 2017-05-24
JIANGSU UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

These separation and purification methods have achieved good results in practical applications, but they also have disadvantages such as cumbersome process, high material consumpt

Method used

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  • Phenylboronic acid modified magnetic nanoparticle, and preparation method and application thereof
  • Phenylboronic acid modified magnetic nanoparticle, and preparation method and application thereof
  • Phenylboronic acid modified magnetic nanoparticle, and preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0043] Example 1: Synthesis of novel phenylboronic acid functionalized magnetic microspheres

[0044] (1) Ferric oxide nanoparticles (Fe 3 o 4 NPs) synthesis

[0045] 0.9 g FeCl 3 ·6H 2 O, 2.890 g NH 4 AC and 0.3 g of trisodium citrate dihydrate were dissolved in a single-necked flask filled with 60 mL of ethylene glycol, and the system was placed in an oil bath at 80 °C for 0.5 h, and a black uniform system was finally obtained. Then the homogeneous system was transferred to a stainless steel autoclave, stirred evenly, reacted at 180 °C for 12 h, cooled to room temperature, separated the black product and washed several times with absolute ethanol, and dried in a vacuum oven for 24 h.

[0046] (2) Preparation of magnetic silica nanoparticles (Fe 3 o 4 @SiO 2 NPs):

[0047] Weigh 0.2 g Fe 3 o 4 NPs were dispersed in 5 mL of dilute hydrochloric acid (0.1 M), and the system was ultrasonically separated for 5 min. The obtained solid was washed several times with disti...

Embodiment 2

[0052] Example 2: Synthesis of novel phenylboronic acid functionalized magnetic microspheres

[0053] (1) Ferric oxide nanoparticles (Fe 3 o 4 NPs) synthesis

[0054] 1.8 g FeCl 3 ·6H 2 O, 4.818 g NH 4 AC and 0.5 g of trisodium citrate dihydrate were dissolved in a single-necked flask filled with 80 mL of ethylene glycol, and the system was placed in an oil bath at 120 °C for 2 h, and a black uniform system was finally obtained. Then the homogeneous system was transferred to a stainless steel high-pressure reactor, stirred evenly, reacted at 220 °C for 20 h, cooled to room temperature, separated the black product and washed several times with absolute ethanol, and dried in a vacuum oven for 24 h.

[0055] (2) Preparation of magnetic silica nanoparticles (Fe 3 o 4 @SiO 2 NPs):

[0056] Weigh 0.4 g Fe 3 o 4 NPs were dispersed in 15 mL of dilute hydrochloric acid (0.1 M), and the system was ultrasonically separated for 20 min before magnetic separation. The obtained s...

Embodiment 3

[0061] Example 3: Synthesis of novel phenylboronic acid functionalized magnetic microspheres

[0062] (1) Ferric oxide nanoparticles (Fe 3 o 4 NPs) synthesis

[0063] 1.35g FeCl 3 ·6H 2 O, 3.854 g NH 4 AC and 0.4 g of trisodium citrate dihydrate were dissolved in a single-necked flask filled with 70 mL of ethylene glycol, and the system was placed in an oil bath at 100 ° C for 1 h, and a black uniform system was finally obtained. Then the homogeneous system was transferred to a stainless steel autoclave, stirred evenly, reacted at 200°C for 16 hours, cooled to room temperature, separated the black product and washed several times with absolute ethanol, and dried in a vacuum oven for 24 hours.

[0064] (2) Preparation of magnetic silica nanoparticles (Fe 3 o 4 @SiO 2 NPs):

[0065] Weigh 0.3g Fe 3 o 4 NPs were dispersed in 10mL of dilute hydrochloric acid (0.1M), and the system was ultrasonically separated for 10min by magnetic separation. The obtained solid was was...

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Abstract

The invention relates to a phenylboronic acid modified magnetic nanoparticle, and a preparation method and application of the phenylboronic acid modified magnetic nanoparticle, and belongs to the technical field of nano materials. Firstly, a magnetic silicon dioxide nanoparticle is prepared, a sulfydryl modified magnetic nanoparticle is prepared through a silanization reaction, the sulfydryl modified magnetic nanoparticle is then dissolved in ethyl alcohol, 4-vinyl phenylboronic acid and AIBN (azodiisobutyronitrile) are then added, the mixture is stirred and reacts in a water bath kettle, a product is magnetically separated, an obtained solid is washed through distilled water and ethyl alcohol and dried to obtain a final product of the phenylboronic acid modified magnetic nanoparticle; and the obtained material is used in enrichment and separation of fructose. The synthesized magnetic material has the advantages of excellent nuclear shell morphology, and can be rapidly separated in an externally applied magnetic field; the adsorption efficiency of fructose of a magnetic microsphere is 6 times that of glucose, the application effects of enrichment and separation of fructose are quite good, and meanwhile, the phenylboronic acid modified magnetic nanoparticle is excellent in repeatability.

Description

technical field [0001] The invention relates to a magnetic nano particle modified by phenylboronic acid, a preparation method and application thereof, and belongs to the technical field of nano materials. Background technique [0002] As a common monosaccharide, fructose plays an important role in the food industry because of its high sweetness, natural taste and good solubility. Fructose has special physiological functions, such as protecting cells, enhancing cell division, increasing platelet function and improving memory. More importantly, compared with its isomer glucose, fructose metabolizes quickly in the human body, is easily absorbed by the body, and has little effect on blood sugar. At the same time, the absorption process does not require the participation of insulin. This makes fructose ideal for fueling diabetics. In view of this, fructose has attracted the attention of researchers at home and abroad for its special physiological effects and good application pr...

Claims

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Application Information

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IPC IPC(8): B01J20/22B01J20/30B01J20/28C13K11/00
CPCB01J20/06B01J20/103B01J20/22B01J20/28009B01J20/28021C13K11/00
Inventor 顾磊王赟韩娟唐旭李程王蕾倪良
Owner JIANGSU UNIV
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