Method for preparing fluorine-containing secondary amine

Abstract

The invention discloses a synthetic method of a fluorine-containing secondary amine compound. Pentamethylcyclopentadienyl iridium chloride dimer is used as a metal catalyst, fluoroalkyl comes from fluorinated alcohol, alkali is used as a co-catalyst, and the fluorine-containing secondary amine is prepared via the following step: primary amine reacts with the fluorinated alcohol under the action of the transition metal iridium catalyst and the alkali in an organic solvent to obtain the fluorine-containing secondary amine compound. The method overcomes the defects in the prior art that the fluorine-containing alkylating agent is high in toxicity and instable and needs to be prepared in advance, the reaction operation is complex, the steps are fussy and the like, and can obtain considerable yield. The adopted fluorinated alcohol is readily available, stable in chemical property and low in toxicity. The method is simple in reaction, has very high atom economy and step economy, and is energy-saving, environment-friendly and simple in operation. By adopting [Cp*IrCl2]2 as the catalyst, ligands are not needed, and the system is easy to realize.

Description

technical field [0001] The invention belongs to the field of organic synthesis, and in particular relates to a method for preparing fluorine-containing secondary amines. Background technique [0002] Secondary amine is a very important structural unit, which widely exists in medicine, pesticide and natural product molecules. Alkylation of primary amines is a basic but important method for the preparation of secondary amines. Since the middle of the 20th century, the importance of fluorine-containing compounds has become more and more prominent in various fields, especially in the field of life sciences. According to statistics, more than 20% of approved drugs and 30-40% of commercialized pesticides contain fluorine. We imagine that if fluorine-containing alkyl chains are introduced into primary amines, the prepared fluorine-containing secondary amines may have some special pharmaceutical activities. Therefore, the research on the preparation of fluorine-containing seconda...

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Problems solved by technology

However, most of the current studies focus on substrates such as alkyl alcohols, aryl alcohols, amino alcohols, and much less research on fluoroalcohols

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