Graphene oxide/molecular imprinting filtering membrane for detecting propranolol, as well as preparation and application thereof

A technology of molecular imprinting and filter membrane, which is applied in the field of materials, can solve the problems of long measurement period, cumbersome processing, expensive instruments, etc.

Active Publication Date: 2017-05-31
NINGBO INST OF MATERIALS TECH & ENG CHINESE ACADEMY OF SCI
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0003] For propranolol, currently commonly used detection methods include high performance liquid chromatography, gas chromatography-mass spectrometry, etc. These methods generally

Method used

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  • Graphene oxide/molecular imprinting filtering membrane for detecting propranolol, as well as preparation and application thereof
  • Graphene oxide/molecular imprinting filtering membrane for detecting propranolol, as well as preparation and application thereof
  • Graphene oxide/molecular imprinting filtering membrane for detecting propranolol, as well as preparation and application thereof

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preparation example Construction

[0151] The present invention also provides a preparation method of the graphene oxide / molecularly imprinted filter membrane, comprising the steps of:

[0152] i) providing a molecularly imprinted prepolymerization solution, a dispersion of graphene oxide, a filter membrane as a substrate, a solution containing imprinted molecules, and an eluent for eluting imprinted molecules;

[0153] ii) uniformly dispersing the dispersion of the graphene oxide on the surface of the filter membrane, suction filtering and optionally drying to obtain a graphene oxide filter membrane;

[0154] iii) immersing the graphene oxide filter membrane in the molecularly imprinted prepolymerization solution, adding a solution containing imprinted molecules, and reacting the resulting mixed solution under a nitrogen atmosphere;

[0155] iv) optionally washing and drying the product obtained in the preceding steps with solvent A;

[0156] v) placing the product obtained in the preceding steps in the eluen...

Embodiment 1

[0170] Example 1 Preparation of Graphene Oxide / Molecularly Imprinted Filter Membrane 1

[0171] 1) First, dissolve 50mL of 0.2M methyl methacrylate in 50mL of methanol solution, and stir evenly for 10min. During the stirring process, slowly add 0.4g of azobisisobutyronitrile and 20mL of ethylene glycol dimethyl acrylate, and continue to stir for 10 minutes to obtain molecularly imprinted prepolymer solution 1.

[0172] 2) Using a nitrocellulose filter as a substrate, 3 mL of graphene oxide dispersion (solid content 2%, specific surface area of ​​graphene oxide 200 m 2 / g) uniformly dispersed on the filter membrane, dried overnight in the air after vacuum filtration on the filter to obtain a graphene oxide filter membrane 1, which should be cleaned with deionized water before each use.

[0173] 3) Soak the graphene oxide filter membrane 1 prepared in step 2) in the 120mL molecularly imprinted pre-polymerization liquid prepared in step 1, after standing for 30min, add 20mL of pro...

Embodiment 2

[0179] Embodiment 2 detects propranolol

[0180] Preparation of Ag nanoparticles

[0181] 20mL silver nitrate solution (10 -2 M), 20mL mass fraction of 1% trisodium citrate solution and 80mL deionized water mix uniformly, add 100mL freshly prepared sodium borohydride solution (10 mL) under strong stirring conditions -2 M), continue to react at room temperature for 1 h to obtain a yellow-green spherical Ag nanoparticle sol with a particle size of 40-70 nm.

[0182] Graphene oxide / molecularly imprinted filter membrane 1+Ag nanoparticles for detection of propranolol

[0183] Put the graphene oxide / molecularly imprinted filter membrane 1 into the syringe filter; draw 2mL, 10 -7 M propranolol solution, put on a syringe filter and inject and filter the propranolol solution; then remove the syringe filter, add 0.5mL of the spherical Ag nanoparticles prepared by the above steps dropwise on it, and perform Raman spectroscopy detection, get the enhanced Raman spectrum, see Figure ...

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Abstract

The invention relates to a graphene oxide/molecular imprinting filtering membrane for detecting propranolol, as well as a preparation and an application thereof. Specifically, the invention discloses a method for detecting propranolol in a detected sample by adopting the graphene oxide/molecular imprinting filtering membrane and a metallic nanometer grain combined raman technique. The detection method has the advantages of high sensitivity, simple and convenient operation, less time consumption, low cost, and the like.

Description

technical field [0001] The invention relates to the field of materials, in particular to a graphene oxide / molecularly imprinted filter membrane for detecting propranolol and its preparation and application. Background technique [0002] Propranolol is one of the most commonly used beta adrenergic blockers for the treatment of arrhythmia, angina pectoris, high blood pressure and other diseases. After taking or injecting, most of it is digested in the human body, but a small part is still discharged into the environment. With the increase of usage, more and more rivers and lakes have found the existence of propranolol. When propranolol enters the human body, it can completely inhibit heart function, induce and aggravate bronchial asthma, and cause adverse reactions such as intermittent claudication. [0003] For propranolol, currently commonly used detection methods include high performance liquid chromatography, gas chromatography-mass spectrometry, etc. These methods genera...

Claims

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Application Information

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IPC IPC(8): G01N21/65
CPCG01N21/658
Inventor 程昱川刘雅娇鲍静静张磊许高杰
Owner NINGBO INST OF MATERIALS TECH & ENG CHINESE ACADEMY OF SCI
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