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Corn prolamine-shellac-curcumin compound colloidal particles and preparation method thereof

A technology of zein and colloidal particles, which is applied in directions such as capsule delivery, microcapsules, and drug combination, can solve the problems of low chemical stability, poor water solubility of curcumin, and low bioavailability, and achieves a simple preparation method and improved Encapsulation rate and loading capacity, the effect of improving water solubility

Inactive Publication Date: 2017-06-13
CHINA AGRI UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0007] Aiming at the deficiencies of poor water solubility, low chemical stability and low bioavailability of curcumin, the present invention provides a zein-shellac-curcumin composite colloid particle and a preparation method thereof, which is characterized in that the particle is made of corn Glamin and shellac are wall materials, curcumin is core material, the mass ratio of zein to shellac is 5:1~1:2, and the mass ratio of wall material to curcumin is 10:1~1: 2

Method used

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  • Corn prolamine-shellac-curcumin compound colloidal particles and preparation method thereof
  • Corn prolamine-shellac-curcumin compound colloidal particles and preparation method thereof
  • Corn prolamine-shellac-curcumin compound colloidal particles and preparation method thereof

Examples

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Effect test

Embodiment 1

[0027] Dissolve 960mg of zein and 480mg of shellac in 40mL of 0.1M phosphate buffer saline containing 80% ethanol by volume, and stir magnetically (600r / min) at room temperature for 2 hours to fully dissolve them. pH to 8.0; 144mg curcumin was dissolved in 40mL of 0.1M phosphate buffer containing volume fraction 48% ethanol, 40vt% acetone, under room temperature dark magnetic stirring (600r / min) 20min, it was fully dissolved, the turmeric The pH of the solution was adjusted to 8.0.

[0028] Zein solution and shellac solution are mixed in equal volumes, so that the mass ratio of zein to shellac is 2:1, vortexed for 30s, left standing at room temperature for 2h to make it fully mixed to form a wall material solution; Mix the wood material solution and the curcumin solution so that the mass ratio of the wall material and curcumin in the mixed solution is 10:1, vortex for 30s, and stand in the dark for 1 hour at room temperature to form a zein-shellac-curcumin mixed solution .

...

Embodiment 2

[0033] Dissolve 960mg of zein and 480mg of shellac in 40mL of 0.1M phosphate buffer saline containing 80% ethanol by volume, and stir magnetically (600r / min) at room temperature for 2 hours to fully dissolve them. pH to 8.0; 480mg of curcumin was dissolved in 40mL of 0.1M phosphate buffer containing 48% ethanol and 40% acetone by volume fraction, and magnetically stirred (600r / min) in the dark at room temperature for 20min to fully dissolve the turmeric The pH of the solution was adjusted to 8.0.

[0034] Zein solution and shellac solution are mixed in equal volumes, so that the mass ratio of zein to shellac is 2:1, vortexed for 30s, left standing at room temperature for 2h to make it fully mixed to form a wall material solution; Mix the wood material solution and the curcumin solution so that the mass ratio of the wall material and curcumin in the mixed solution is 2:1, vortex for 30s, and stand in the dark for 1 hour at room temperature to form a zein-shellac-curcumin mixed ...

Embodiment 3

[0039] Dissolve 480mg of zein and 480mg of shellac in 40mL of 0.1M phosphate buffer saline containing 80% ethanol by volume fraction, magnetically stir (600r / min) at room temperature for 2h to fully dissolve, and adjust the above solutions respectively pH to 8.0; 480mg of curcumin was dissolved in 40mL of 0.1M phosphate buffer containing 48% ethanol and 40% acetone by volume fraction, and magnetically stirred (600r / min) in the dark at room temperature for 20min to fully dissolve the turmeric The pH of the solution was adjusted to 8.0.

[0040] Zein solution and shellac solution are mixed in equal volumes, so that the mass ratio of zein to shellac is 1:1, vortexed for 30s, left standing at room temperature for 2h to fully mix, and form a wall material solution; Mix the wood material solution and the curcumin solution so that the mass ratio of the wall material and curcumin in the mixed solution is 2:1, vortex for 30s, and stand in the dark for 1 hour at room temperature to form...

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Abstract

The invention discloses corn prolamine-shellac-curcumin compound colloidal particles and a preparation method thereof and belongs to the technical field of preparation of the compound colloidal particles. The compound colloidal particles take corn prolamine and shellac as wall materials and take curcumin as a core material, and are prepared by adopting an anti-solvent co-precipitation method; the mass ratio of the corn prolamine to the shellac ranges from (5 to 1) to (1 to 2) and the mass ratio of the wall materials to the curcumin ranges from (10 to 1) to (1 to 2); the corn prolamine, the shellac and the curcumin are combined through hydrogen bonds and a hydrophobic interaction effect. According to the compound colloidal particles provided by the invention, the embedding rate on the curcumin is more than 90 percent; the water solubility of the curcumin is extremely increased and the light degradation and thermal degradation speeds of the curcumin are effectively reduced; the bioavailability of the curcumin is remarkably improved, controlled release of the curcumin is realized to a certain extent and a releasing speed of the curcumin in intestinal fluid is reduced; According to the corn prolamine-shellac-curcumin compound colloidal particles provided by the embodiment of the invention, a new concept and a new way can be provided for a steady state of functional factors.

Description

technical field [0001] The invention belongs to the technical field of preparation of composite colloidal particles, and in particular relates to a zein-shellac-curcumin composite colloidal particle and a preparation method thereof. Background technique [0002] As a fat-soluble polyphenol, curcumin has wide applicability in the prevention and treatment of cardiovascular diseases such as Alzheimer's disease, Parkinson's disease, and atherosclerosis. However, due to curcumin's low water solubility, poor chemical stability, fast metabolism in the human body, and low bioavailability, there are great limitations in production, processing and application. Existing studies have shown that colloidal particles based on polysaccharides and proteins can be used for the embedding, protection and delivery of various biologically active substances. [0003] As a natural plant protein, zein is not only cheap, safe and non-toxic, but also has good biocompatibility and degradability. Base...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/50A61K31/12A61K47/44A61K47/69A61K47/64A61P35/00A61P29/00A61P39/06
CPCA61K9/5015A61K31/12
Inventor 高彦祥孙翠霞许辰琪代蕾
Owner CHINA AGRI UNIV
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