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Astragalus polysaccharide-angelica polysaccharide composition iron supplement as well as preparation method and application

A technology of astragalus polysaccharides and iron supplements, which is applied in the direction of drug combinations, pharmaceutical formulas, plant raw materials, etc., can solve the problems of unsatisfactory iron supplementation effects, low human absorption rate, strong side effects, etc., and achieve clear pharmacological effects and mechanisms. Broad application prospects, the effect of preventing iron poisoning

Inactive Publication Date: 2017-06-13
BEIJING UNIV OF CHINESE MEDICINE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Currently used blood iron supplements mainly include ferrous sulfate, ferrous organic acid salts, etc., but there are generally disadvantages such as low absorption rate, peculiar smell, strong side effects, etc., and the effect of iron supplementation is not ideal.

Method used

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  • Astragalus polysaccharide-angelica polysaccharide composition iron supplement as well as preparation method and application
  • Astragalus polysaccharide-angelica polysaccharide composition iron supplement as well as preparation method and application
  • Astragalus polysaccharide-angelica polysaccharide composition iron supplement as well as preparation method and application

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Experimental program
Comparison scheme
Effect test

Embodiment 1

[0036] The mass percent of each component of this iron supplement is:

[0037] Astragalus polysaccharide 46.7%, Angelica polysaccharide 28.3%, water phase Fe 3 o 4 Superparamagnetic nanoparticles 25%.

[0038] Step (1) prepares the Fe of oil phase 3 o 4 Superparamagnetic nanoparticles;

[0039] Step (2) uses the polar small molecule that contains carboxyl to the Fe of oily phase 3 o 4 The surface of superparamagnetic nanoparticles is modified, and the polar small molecule is coordinated with the metal ion on the surface of the nanoparticle through the carboxyl group, so that Fe 3 o 4 Nanoparticles change from the oil phase to the water phase, enabling them to be uniformly and stably suspended in the water phase solution;

[0040] Step (3) using enzyme-Sevag cross-linking method and ethanol precipitation method to fully purify the astragalus polysaccharide and angelica polysaccharide with polysaccharide content of 30%, remove protein, plant pigment and other impurities,...

Embodiment 2

[0042] Embodiment 2: the mass percent of each component of this iron supplement is:

[0043] Astragalus polysaccharide 26.6%, Angelica polysaccharide 48.4%, water phase Fe 3 o 4 Superparamagnetic nanoparticles 25%.

[0044] Step (1) prepares the Fe of oil phase 3 o 4 Superparamagnetic nanoparticles;

[0045] Step (2) uses the polar small molecule that contains carboxyl to the Fe of oily phase 3 o 4 The surface of superparamagnetic nanoparticles is modified, and the polar small molecule is coordinated with the metal ion on the surface of the nanoparticle through the carboxyl group, so that Fe 3 o 4 Nanoparticles change from the oil phase to the water phase, enabling them to be uniformly and stably suspended in the water phase solution;

[0046] Step (3) using enzyme-Sevag cross-linking method and ethanol precipitation method to fully purify the astragalus polysaccharide and angelica polysaccharide with polysaccharide content of 30%, remove protein, plant pigment and oth...

Embodiment 3

[0048] Embodiment 3: the mass percent of each component of this iron supplement is:

[0049] Astragalus polysaccharide 26.3%, Angelica polysaccharide 26.7%, water phase Fe 3 o 4 Superparamagnetic nanoparticles 47%.

[0050] Step (1) prepares the Fe of oil phase 3 o 4 Superparamagnetic nanoparticles;

[0051] Step (2) uses the polar small molecule that contains carboxyl to the Fe of oily phase 3 o 4 The surface of superparamagnetic nanoparticles is modified, and the polar small molecule is coordinated with the metal ion on the surface of the nanoparticle through the carboxyl group, so that Fe 3 o 4 Nanoparticles change from the oil phase to the water phase, enabling them to be uniformly and stably suspended in the water phase solution;

[0052] Step (3) using enzyme-Sevag cross-linking method and ethanol precipitation method to fully purify the astragalus polysaccharide and angelica polysaccharide with polysaccharide content of 30%, remove protein, plant pigment and oth...

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Abstract

The invention relates to the field of traditional Chinese pharmacology and nanotechnology, in particular to an astragalus polysaccharide-angelica polysaccharide composition iron supplement as well as a preparation method and an application. The iron supplement is prepared from, in percentage by mass, 23%-58% of aqueous phase Fe3O4 superparamagnetic nanoparticles serving as cores, 4%-72% of astragalus polysaccharide and 5%-62% of angelica polysaccharide, wherein astragalus polysaccharide and angelica polysaccharide coat the surfaces of aqueous phase Fe3O4 superparamagnetic nanoparticle cores. The preparation method is scientific and reasonable, the pharmacological action and mechanism are clear, and the iron supplement can play a good role in treating both symptoms and root causes of iron deficiency anemia, can have a good iron supplement effect at the daily iron supplement amount of 1 mg / kg (lower than 2 mg / kg), can reduce the iron load of the organism and prevent iron poisoning and has broad application prospects.

Description

[0001] Technical field: [0002] The invention relates to the fields of traditional Chinese medicine and nanotechnology, in particular to an iron supplement composed of astragalus polysaccharide-angelica polysaccharide and its preparation method and application. Background technique [0003] At present, iron deficiency anemia (iron deficiency anemia, IDA) refers to the anemia that occurs when the iron storage in the body cannot meet the needs of normal erythropoiesis. Or lose too much. Iron deficiency anemia is extremely harmful to the body. Iron deficiency can significantly reduce children's intelligence and motor development, and reduce people's immune function, physical strength, and endurance; Infant mortality is associated; iron deficiency can also damage the digestive tract, hair, nails, and skin. In short, iron deficiency anemia is one of the four most serious nutritional diseases in the contemporary world, which seriously affects human health. According to statistic...

Claims

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Application Information

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IPC IPC(8): A61K36/481A61K9/51A61P7/06A61K33/26A61K31/715
CPCA61K36/232A61K9/5161A61K31/715A61K33/26A61K36/481A61K2300/00
Inventor 李丽娜畅洪昇陈萌王淑艳葛东宇耿青霞赵宏照宗晨钟
Owner BEIJING UNIV OF CHINESE MEDICINE
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