Unlock instant, AI-driven research and patent intelligence for your innovation.

A safe, efficient and durable antibacterial nano hydrogel and its preparation method

A nano-hydrogel, high-efficiency technology, applied in the field of hydrogel materials and its preparation, can solve the problems of harming human health, high cost, color change, and restricting the development of inorganic nano-composite hydrogels, achieving low energy consumption, Efficient and long-lasting antibacterial effect, mild reaction conditions

Inactive Publication Date: 2019-03-08
DONGHUA UNIV
View PDF4 Cites 0 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

These inorganic nanocomposite hydrogels often use Ag and other heavy metal particles for antibacterial, but in the past few years, due to the disadvantages of Ag particles such as expensive cost, color change, and more importantly, these heavy metal particles will continue to accumulate in the human body There is a risk of harming human health, which limits the development of inorganic nanocomposite hydrogels

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • A safe, efficient and durable antibacterial nano hydrogel and its preparation method
  • A safe, efficient and durable antibacterial nano hydrogel and its preparation method
  • A safe, efficient and durable antibacterial nano hydrogel and its preparation method

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0037](1) Add 0.5g sodium carboxymethyl cellulose to 25ml deionized water, let it stand for 24h, adjust the pH to 8 with 0.1mol / L NaOH solution, add 10ml methacrylic anhydride drop by drop, slowly in an ice bath Stir for 24h. After the reaction is completed, precipitate with ethanol for 2-3 times, filter and dry in a vacuum oven to obtain sodium carboxymethyl cellulose monomer.

[0038] (2) Add 5g of guanidine hydrochloride hydrochloride to 25ml of absolute ethanol, heat to 45°C until the guanidine hydrochloride is completely dissolved, then add 4.2ml of methacrylic anhydride dropwise, raise the temperature to 90°C and continue stirring for 10h, cool down after the reaction is complete After reaching room temperature, the reaction mixture was precipitated with ethyl acetate and dried in a vacuum oven to obtain an organic guanidine salt monomer.

[0039] (3) Dissolve 50 mg of sodium carboxymethyl cellulose monomer and 70 mg of organic guanidine salt monomer in 20 ml of deioniz...

Embodiment 2

[0043] (1) Add 0.5g sodium carboxymethyl cellulose to 25ml deionized water, let it stand for 24h, adjust the pH to 8 with 0.1mol / L NaOH solution, add 10ml acrylic anhydride dropwise, and stir slowly in an ice bath for 24h . After the reaction is completed, precipitate with ethanol for 2-3 times, filter and dry in a vacuum oven to obtain sodium carboxymethyl cellulose monomer.

[0044] (2) Add 5g of guanidine hydrochloride hydrochloride to 25ml of absolute ethanol, heat to 45°C until the guanidine hydrochloride is completely dissolved, then add 4.2ml of acrylic anhydride dropwise, raise the temperature to 85°C and continue stirring for 10h, then cool to room temperature after the reaction is complete After the reaction, the mixture was precipitated with ethyl acetate and dried in a vacuum oven to obtain an organic guanidine salt monomer.

[0045] (3) Dissolve 50 mg of sodium carboxymethyl cellulose monomer and 70 mg of organic guanidine salt monomer in 20 ml of deionized water...

Embodiment 3

[0048] (1) Add 0.5g sodium carboxymethyl cellulose to 25ml deionized water, let it stand for 24h, adjust the pH to 8 with 0.1mol / L NaOH solution, add 10ml acrylic anhydride dropwise, and stir slowly in an ice bath for 24h . After the reaction is completed, precipitate with ethanol for 2-3 times, filter and dry in a vacuum oven to obtain sodium carboxymethyl cellulose monomer.

[0049] (2) Add 5g of polyhexamethyleneguanidine hydrochloride to 10ml of deionized water, stir and dissolve it in a 100ml single-necked flask, take 2ml of methacrylic anhydride and dissolve it in 4ml of dioxane, and dissolve the dissolved methyl The mixture of acrylic anhydride and dioxane was added dropwise to the reaction flask, then 3.5ml triethylamine was added during the stirring process, and the reaction was carried out overnight at room temperature. Guanidine salt monomer.

[0050] (3) Dissolve 85 mg of sodium carboxymethylcellulose monomer and 77 mg of organic guanidine salt monomer in 20 ml o...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

PropertyMeasurementUnit
particle sizeaaaaaaaaaa
Login to View More

Abstract

The invention provides safe, efficient and lasting antibacterialnanohydrogel and a preparation method thereof. The nanohydrogel is prepared from following raw materials in parts by weight: 25-100 parts of cellulose or a cellulose derivative polymerizable monomer, 35-140 parts of an organic guanidine salt polymerizable monomer, 10,000-40,000 parts of deionized water and 0.1-5 parts of an initiator. For preparation, the antibacterialnanohydrogel is synthesized from the cellulose or the cellulose derivative polymerizable monomer and theorganic guanidine salt polymerizable monomer through copolymerization. A large quantity of guanidyl groups with an antibacterial function is distributed on the surface and inside of the hydrogel prepared with the method, so that the antibacterial effect of the hydrogel is remarkable; by means of the preparation method of the antibacterial nanohydrogel, reaction conditions are mild, industrial production is easy, energy consumption is low, no organic solvent is used, and pollution is avoided; the cellulose or the cellulose derivative polymerizable monomer and the organic guanidine salt polymerizable monomer are safe and non-toxic, and the nanohydrogel prepared through polymerization is good in biocompatibility and has no toxic effect on human bodies.

Description

technical field [0001] The invention belongs to the field of hydrogel materials and preparation thereof, in particular to a safe, efficient and durable antibacterial nano hydrogel and a preparation method thereof. Background technique [0002] Hydrogel is a kind of polymer with a three-dimensional network structure. Compared with conventional water-absorbing materials, it can absorb a large amount of water or saline and swell, and can continue to maintain its original structure without being dissolved after swelling; nano-hydrogels Nanohydrogel or nanogel is a hydrogel particle with a particle size usually in the range of 1 to 1000 nm. Due to its excellent hydrophilicity, high expansion rate and biocompatibility, nanohydrogels are widely used in agriculture, biomedicine, tissue engineering, biosensors, drug delivery and adsorbents; nanohydrogels Because it contains a lot of water, it is very soft and similar to biological tissue, so it is often used as a human implant, and ...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
Patent Type & Authority Patents(China)
IPC IPC(8): C08J3/075C08F251/02C08F220/00C08B13/00
CPCC08B13/00C08F251/02C08J3/075C08J2351/02C08F220/00
Inventor 吴德群韩华覃小红
Owner DONGHUA UNIV