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A kind of nano-silver composite collagen medical dressing and preparation method thereof

A nano-silver and composite glue technology, applied in medical science, bandages, etc., can solve the problems of lack of antibacterial, poor mechanical properties and water resistance of pure collagen sponges, and achieve broad-spectrum antibacterial properties and good biocompatibility , rapid hemostatic effect

Inactive Publication Date: 2020-01-14
SICHUAN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, collagen does not have antibacterial ability, and some toxic and harmful microorganisms tend to grow crazily in the collagen matrix; in addition, the mechanical properties and water resistance of pure collagen sponge are poor, and its use alone cannot meet the requirements of market applications

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0017] After blending the dialdehyde xanthan gum solution with a mass concentration of 1% and the silver nitrate solution with a mass concentration of 2%, it was stirred at room temperature in the dark for 20 minutes, then the mixed solution was boiled, condensed and refluxed for 30 minutes, and after cooling to room temperature, the It was dialyzed for 5 days, then centrifuged at a speed of 6000r / min for 10min, and the supernatant was taken to obtain a nano-silver solution; the collagen was dissolved in deionized water to obtain a collagen solution with a mass concentration of 0.4%, and then injected into the mold. A collagen sponge with a thickness of 4 nm was prepared by freeze-drying, then soaked in the above-prepared nano-silver solution for 30 minutes, and freeze-dried to obtain a nano-silver composite collagen medical dressing.

Embodiment 2

[0019] Blend the dialdehyde carboxymethyl cellulose and dialdehyde inulin solution with a mass concentration of 5% and the silver nitrate solution with a mass concentration of 5%, and then stir at room temperature in the dark for 30 minutes, then boil the mixed solution, condense and reflux for 40 minutes After being cooled to room temperature, it was dialyzed for 5 days, then centrifuged at a speed of 7000r / min for 10min, and the supernatant was taken to obtain a nano-silver solution; the collagen was dissolved in deionized water to obtain a collagen solution with a mass concentration of 0.7%. Then pour it into a mold, prepare a collagen sponge with a thickness of 5 nm by freeze-drying, then soak it in the nano-silver solution prepared above for 25 minutes, and obtain a nano-silver composite collagen medical dressing after freeze-drying.

Embodiment 3

[0021] Blend the dialdehyde starch solution with a mass concentration of 0.5% and the silver nitrate solution with a mass concentration of 7%, and stir at room temperature in the dark for 30 minutes, then boil the mixed solution, condense and reflux for 20 minutes, and dialyze it after cooling to room temperature After 5 days, centrifuge at a speed of 5000r / min for 15min, take the supernatant to obtain the nano-silver solution; dissolve the collagen in deionized water to obtain a collagen solution with a mass concentration of 0.5%, then pour it into the mold, and freeze A collagen sponge with a thickness of 3 nm was prepared by drying, then soaked in the above-prepared nano-silver solution for 28 minutes, and freeze-dried to obtain a nano-silver composite collagen medical dressing.

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Abstract

The invention relates to nano-silver composite collagen surgical dressing and a preparation method of the nano-silver composite collagen surgical dressing. The preparation method comprises the following steps: uniformly mixing a dialdehyde polysaccharide solution and silver nitrate solution, completely boiling the mixed solution, carrying out reflux condensation, after the mixed solution is cooled to the room temperature, carrying out dialysis and centrifugalizing, taking the supernate, thus obtaining nano-silver solution, soaking collagen sponge in the nano-silver solution, and carrying out freeze drying, thus obtaining the nano-silver composite collagen surgical dressing. The stable nano-silver solution with narrow particle size distribution range is prepared by adopting a pollution-free reduction method, in addition, dialdehyde polysaccharide in the solution can have Schiff base chemical crosslinking reaction with collagen, and thus the physical properties of the collagen sponge are enhanced. The prepared nano-silver composite collagen surgical dressing has the advantages of broad-spectrum antibacterial activity, rapid bleeding-stopping property, high mechanical property, good moisture retention and biocompatibility, and has the potential market application prospect in the field of treating burns and scalds.

Description

technical field [0001] The invention relates to the technical field of biomedical materials, in particular to a composite collagen medical dressing which has the characteristics of broad-spectrum bacteriostasis, rapid hemostasis, good moisture retention and biocompatibility and can promote the rapid healing of burns and scald wounds and its preparation method. Background technique [0002] Burns and scalds are common in everyday life. Burn and scald wounds are easily infected by pathogenic microorganisms. Therefore, chemical drugs such as antibiotics, disinfectants, and bactericides are widely used clinically to kill microorganisms and promote rapid wound healing. The extensive use of its chemical drugs will cause the resistance of microorganisms, such as the resistance of Escherichia coli to kanamycin and streptomycin, and the resistance of Salmonella typhi to chloramphenicol. Global microbial disasters caused by microbial resistance frequently occur, so research and deve...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61L26/00
CPCA61L26/0066A61L26/0085A61L26/0095A61L2300/104A61L2300/404C08L89/00
Inventor 李德富葛黎明穆畅道史鲁浙杨森
Owner SICHUAN UNIV
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