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Preparation method of loofah sponge anti-adhesion dressing for wound surface

A technology of loofah and anti-adhesion, which is applied in the preparation of loofah anti-adhesion wound dressing and the preparation of natural plant fiber anti-adhesion wound dressing, which can solve the problems of wound granulation tissue adhesion and secondary trauma, and achieve anti-adhesion performance Good, ensure safety, avoid tissue adhesion effect

Active Publication Date: 2017-09-08
NANJING UNIV OF SCI & TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] However, there is a big defect in the cell adhesion of the loofah-based dressing prepared by the above method, and the wound granulation tissue is easy to grow into the dressing to cause tissue adhesion, causing secondary trauma when the dressing is removed.

Method used

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  • Preparation method of loofah sponge anti-adhesion dressing for wound surface
  • Preparation method of loofah sponge anti-adhesion dressing for wound surface
  • Preparation method of loofah sponge anti-adhesion dressing for wound surface

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preparation example Construction

[0022] The preparation method of a kind of loofah anti-adhesion wound dressing of the present invention is to take loofah sponge body as the base material and form by grafting and modifying by Schiff base reaction. The schematic flow chart is as follows: figure 1 As shown, first graft aldehyde groups on the surface of loofah, then graft carboxymethyl chitosan, and finally graft alginate sodium alginate, specifically comprising the following steps:

[0023] Step 1, at room temperature, the loofah is immersed in an aqueous solution of potassium periodate with a concentration of 1.5-3wt% potassium periodate under the condition of avoiding light, stirred and reacted for 4-12 hours, and then washed to obtain the aldylated loofah;

[0024] Step 2, immersing the aldylated loofah in an aqueous carboxymethyl chitosan solution with a concentration of 0.25 to 1.5 wt% at room temperature, and reacting for 5 to 15 minutes to obtain a loofah grafted with carboxymethyl chitosan;

[0025] Ste...

Embodiment 1

[0030] (1) at room temperature, the loofah is immersed in a concentration of 2wt% potassium periodate aqueous solution under light-proof conditions, stirred and reacted for 8 hours, and then cleaned to obtain the aldylated loofah;

[0031] (2) immerse the aldylated loofah at room temperature in the carboxymethyl chitosan aqueous solution with a concentration of 1.5wt%, and react for 15 minutes to obtain the luffa of grafted carboxymethyl chitosan;

[0032] (3) 1.0 g of sodium alginate was dissolved in 100 ml of water at room temperature, then 1 g of sodium periodate was added, stirred for 4 hours in the dark, dialyzed and freeze-dried to obtain formylated sodium alginate;

[0033] (4) Immerse the loofah grafted with carboxymethyl chitosan in an aqueous solution of 1.5 wt% alginate sodium alginate at room temperature, react for 15 minutes, and freeze-dry to obtain the loofah anti-adhesion wound dressing.

[0034] The microstructure of the dressing before and after modification ...

Embodiment 2

[0036] The specific operation steps are:

[0037] (1) Under room temperature, the loofah is immersed in a concentration of 1.5wt% potassium periodate aqueous solution under light-proof conditions, stirred and reacted for 4 hours, and then cleaned to obtain the aldylated loofah;

[0038] (2) immerse the aldylated loofah at room temperature in the carboxymethyl chitosan aqueous solution of 0.25wt%, and react for 5 minutes to obtain the luffa of grafted carboxymethyl chitosan;

[0039] (3) 1.0 g of sodium alginate was dissolved in 100 ml of water at room temperature, then 0.5 g of sodium periodate was added, stirred for 1 hour in the dark, dialyzed and freeze-dried to obtain formylated sodium alginate;

[0040] (4) The loofah grafted with carboxymethyl chitosan was immersed in 0.25 wt% aqueous solution of alginate alginate at room temperature, reacted for 5 minutes, and freeze-dried to obtain the loofah anti-adhesion wound dressing.

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Abstract

The invention discloses a preparation method of loofah sponge anti-adhesion dressing for the wound surface. According to the preparation method, loofah plant fibers are adopted as the base material, polysaccharide molecules are grafted through conjugation reaction, so that the tissue anti-adhesion property of the natural plant fiber dressing for the wound surface is improved, and the effective protection for the wound of the skin is realized. The loofah sponge anti-adhesion dressing for the wound surface can be directly applied to the wound surface, has the extremely excellent absorption effect, and is particularly suitable for treating the skin diseases including burns, pus, wound drainage, anabrosis and the like. The hydrophilic performance and tissue-adhesion-resisting property of the natural plant fiber dressing for the wound surface are obviously improved, and meanwhile, the toxic chemical crosslinking agent is not used, so that the biocompatibility and the safety of the dressing are improved. The process is simple, the cost is low, the modifying temperature is low, the grafting speed is high, and the method is suitable for large-scale industrial production.

Description

technical field [0001] The invention belongs to the technical field of tissue engineering scaffold materials, and relates to a preparation method of a natural plant fiber anti-adhesion wound dressing, and more particularly relates to a preparation method of a loofah anti-adhesion wound dressing. Background technique [0002] A dressing is a medical material used to temporarily cover a wound. Its main function is to control the exudate of the wound and protect the wound from contamination by bacteria and dust particles, and to provide an environment conducive to wound healing. Cell adhesion affects the effectiveness of dressings. Dressings with strong cell adhesion tend to adhere to granulation tissue, causing secondary damage to migrating epithelial cells and proliferating fibroblasts when the dressing is removed. [0003] The sponge body based on natural plant fiber has good biocompatibility and has a variety of reactive active functional groups on the molecular chain. It ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L15/40A61L15/28A61L15/42
CPCA61L15/28A61L15/40A61L15/425
Inventor 谈华平范茗马烨陈勇凌中华
Owner NANJING UNIV OF SCI & TECH
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