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A method for preparing macroporous bioactive glass nanoclusters using dendritic polyethyleneimine as template and catalyst

A bioactive glass, polyethyleneimine technology, applied in glass forming, glass manufacturing equipment, manufacturing tools and other directions, to achieve the effects of simple and easy preparation technology, mild reaction conditions, and good gene loading capacity

Active Publication Date: 2020-03-13
XI AN JIAOTONG UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, no one has tried to use polyethyleneimine, a dendritic polymer, as a template to regulate the shape and size of bioactive glasses.

Method used

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  • A method for preparing macroporous bioactive glass nanoclusters using dendritic polyethyleneimine as template and catalyst
  • A method for preparing macroporous bioactive glass nanoclusters using dendritic polyethyleneimine as template and catalyst
  • A method for preparing macroporous bioactive glass nanoclusters using dendritic polyethyleneimine as template and catalyst

Examples

Experimental program
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Effect test

Embodiment 1

[0033] 1) Preparation of polyethyleneimine alcohol aqueous solution: dendritic polyethyleneimine is dissolved in alcohol aqueous solution at 40° C. to obtain transparent polyethyleneimine alcohol aqueous solution; wherein, the volume ratio of alcohol to water is 3: 1. Molecular weight (M w ) is 25000 polyethyleneimine dissolved in alcohol aqueous solution under magnetic rotor stirring, the molar weight of dissolved polyethyleneimine is 10% of the silane molar weight in the reaction;

[0034] 2) Hydrolysis and condensation of silane: Ethyl orthosilicate is slowly added dropwise to the aqueous solution of polyethyleneimine alcohol under magnetic rotor stirring, and the hydrolysis and condensation reaction starts at 40°C. Among them, the volume of silane and absolute ethanol The ratio is 1:40;

[0035] 3) Add calcium source and phosphorus source: After adding tetraethyl orthosilicate for 30 minutes, slowly add triethyl phosphate as a phosphorus source and react for 30 minutes, t...

Embodiment 2

[0038] (1) Preparation of polyethyleneimine alcohol aqueous solution: dissolving dendritic polyethyleneimine in alcohol aqueous solution at 40°C to obtain transparent polyethyleneimine alcohol aqueous solution; wherein, the volume ratio of alcohol to water is 3 :1, molecular weight (M w) is 25000 polyethyleneimine dissolved in alcohol aqueous solution under magnetic rotor stirring, the molar weight of dissolved polyethyleneimine is 20% of the silane molar weight in the reaction;

[0039] (2) Hydrolysis and condensation of silane: Ethyl orthosilicate is slowly added dropwise to the aqueous solution of polyethyleneimine alcohol under magnetic rotor stirring, and the hydrolysis and condensation reaction starts at 40°C. The volume ratio is 1:40;

[0040] (3) Add calcium source and phosphorus source: After adding tetraethyl orthosilicate for 30 minutes, slowly add triethyl phosphate as a phosphorus source and react for 30 minutes, then add calcium nitrate tetrahydrate as a calcium...

Embodiment 3

[0043] (1) Preparation of polyethyleneimine alcohol aqueous solution: dissolving dendritic polyethyleneimine in alcohol aqueous solution at 40°C to obtain transparent polyethyleneimine alcohol aqueous solution; wherein, the volume ratio of alcohol to water is 3 :1, molecular weight (M w ) is 25000 polyethyleneimine dissolved in alcohol aqueous solution under magnetic rotor stirring, the molar weight of dissolved polyethyleneimine is 30% of the silane molar weight in the reaction;

[0044] (2) Hydrolysis and condensation of silane: Ethyl orthosilicate is slowly added dropwise to the aqueous solution of polyethyleneimine alcohol under magnetic rotor stirring, and the hydrolysis and condensation reaction starts at 40°C. The volume ratio is 1:40;

[0045] (3) Add calcium source and phosphorus source: After adding tetraethyl orthosilicate for 30 minutes, slowly add triethyl phosphate as a phosphorus source and react for 30 minutes, then add calcium nitrate tetrahydrate as a calciu...

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Abstract

The invention discloses a method for preparing a macro-porous bioactive glass nano-cluster through adopting dendritic polyethylene imine as a template and a catalyst. The method comprises the following steps: dissolving the dendritic polyethylene imine in an alcohol-water mixed solution to obtain a transparent alcohol-water solution of polyethylene imine; adding silane, and carrying out hydrolytic condensation to obtain a gradual turbid sol; adding triethyl phosphate and calcium nitrate to introduce a phosphorus source and a calcium source to obtain a milky bioactive glass-sol solution; and purifying the finally obtained product to obtain white powder of the bioactive glass nano-cluster. The preparation method has the advantages of simplicity, easiness in implementation, mild reaction conditions, and realization of regulation of the morphology and the dimension of the bioactive glass through using the dendritic polyethylene imine polymer as the template and the catalyst; and the prepared bioactive glass has the advantages of good bioactivity, good biocompatibility and excellent gene load ability, and can be widely applied to the biomedical fields of tissue restoration and building, and cancer therapy.

Description

【Technical field】 [0001] The invention relates to a preparation technology of macroporous bioactive glass nanoclusters for bone tissue repair and regeneration, protein and drug delivery, and gene therapy, in particular to a preparation of macroporous bioactive glass nanoclusters using dendritic polyethyleneimine as a template and a catalyst. Porous methods for bioactive glass nanoclusters. 【Background technique】 [0002] Bioactive glass is a silicate glass based on a glass network formed by three-dimensional silicon-oxygen tetrahedrons and doped with other elements such as Ca, P, and Na as modifiers. Because bioactive glass has good biological activity, biocompatibility and osteogenic gene activation ability, it can form chemical bonds with bone tissue and soft tissue and promote it, so it has been widely used in the repair and reconstruction of bone defects and skin tissue. application. [0003] Micro-nano bioactive glass has more superior performance due to its relativel...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C03B8/02C03B19/00
CPCC03B19/12
Inventor 雷波薛语萌
Owner XI AN JIAOTONG UNIV
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