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A kind of glucose sensing electrode and its preparation method and application

A technology for sensing electrodes and glucose, which is applied in the field of electrochemistry, can solve the problems of low detection limit and achieve the effects of low detection limit, widening linear range and high photoelectric conversion efficiency

Active Publication Date: 2019-08-27
UNIV OF SCI & TECH OF CHINA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

In this work, although the material showed high detection sensitivity, the detection limit was much lower than the former
This means that under the same concentration of blood glucose testing conditions, the latter may need to use more serum samples

Method used

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  • A kind of glucose sensing electrode and its preparation method and application
  • A kind of glucose sensing electrode and its preparation method and application
  • A kind of glucose sensing electrode and its preparation method and application

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Experimental program
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preparation example Construction

[0045] The present invention provides a method for preparing a glucose sensing electrode described in the above technical solution, comprising the following steps:

[0046] a), provide Cu 2 O thin film electrodes, the Cu 2 The O thin film electrode comprises a conductive glass layer and Cu compounded on the surface of the conductive glass layer 2 O layer;

[0047] b), the Cu 2 The O film electrode was immersed in trimesic acid solution for reaction to obtain the glucose sensing electrode material.

[0048] In the preparation method provided by the invention, at first provide Cu 2 O thin film electrodes, the Cu 2 The O thin film electrode comprises a conductive glass layer and Cu compounded on the surface of the conductive glass layer 2 O layer, the Cu 2 The O thin film electrode is preferably prepared according to the following method:

[0049] 1), adjust the pH value to 9.3~12.3 after copper salt, complexing agent and water are mixed, obtain electrolytic solution;

...

Embodiment 1

[0062] Example 1: Cu 2 Preparation and Characterization of O / Cu-BTC Composite Glucose Sensing Electrode

[0063] The ITO glass substrate was ultrasonically cleaned with 10%wt sodium hydroxide solution and 5-6vol% hydrochloric acid solution for 20s in sequence, then ultrasonically cleaned with distilled water, absolute ethanol and acetone for 20min, and dried.

[0064] Weigh 10g CuSO 4 ·5H 2 O (0.4M), 36.032g of lactic acid (4M) were added to a 100mL volumetric flask and the volume was constant to the mark to obtain the electrolyte solution. Subsequently, the pH value of the electrolyte was adjusted to 10.50 with concentrated potassium hydroxide solution, and stirred for 30 min.

[0065] Next, electrochemical deposition was performed using Chi660B electrochemical workstation. A three-electrode system was adopted: ITO glass substrate was used as working electrode, platinum sheet was used as counter electrode, and saturated Ag / AgCl electrode was used as reference electrode. ...

Embodiment 2

[0076] Example 2: Cu 2 O / Cu-BTC composite glucose sensing electrode for photoelectrochemical glucose detection method

[0077] The experimental conditions are:

[0078] 1) Use an electrochemical workstation to detect, using a three-electrode system: with the Cu obtained in Example 1 2 The O / Cu-BTC composite glucose sensing electrode was used as the working electrode (the area of ​​the working electrode was 2cm 2 ), the platinum sheet is used as the counter electrode, and the saturated Ag / AgCl electrode is used as the reference electrode;

[0079] 2) The electrolyte is 0.05M sodium hydroxide solution, and the electrochemical detection voltage is 0.6V;

[0080] 3) The light condition is an intensity of 100mW / cm 2 Visible light is provided by a 300W xenon light source equipped with a cut 400 filter;

[0081] 4) For the schematic diagram of the experimental device, see Figure 4 , Figure 4 It is a schematic diagram of the experimental device for photoelectrochemical glucos...

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Abstract

The invention belongs to the field of electrochemistry, and particularly relates to a glucose sensor electrode and a preparation method and the application of the glucose sensor electrode. The provided glucose sensor electrode comprises a conductive glass layer, a Cu2O layer compounded on the surface of the conductive glass layer, and a Cu-BTC metal organic framework material compounded on the surface of the Cu2O layer. The provided glucose sensor electrode is higher in photoelectric conversion efficiency. The invention further provides a glucose photoelectric chemical detection method, applying the prepared glucose sensor electrode to the photoelectric chemical detection of glucose effectively improves the detection sensitivity of the glucose and expands the linear interval of detection of the glucose, and a relatively low detection limit is realized. The experimental result proves that when the provided glucose sensor electrode is used as a working electrode to detect the glucose in a sample, the detection sensitivity is up to 4.029 muA / muM, the linear interval is expanded to 0.1-150 muM, and the detection limit is as low as 0.06 muM.

Description

technical field [0001] The invention belongs to the field of electrochemistry, and in particular relates to a glucose sensing electrode and a preparation method and application thereof. Background technique [0002] According to the statistics of the International Diabetes Federation (IDF), there were 415 million diabetics in the world in 2015, that is, one in every 11 people on average, and it is expected that the number of patients will continue to grow to 642 million by 2040. Especially in low- and middle-income developing countries and regions, this growth trend is more obvious. Sustained high blood sugar will damage various tissues and organs of the human body, such as cardiovascular disease, renal failure, amputation, blindness and so on. Statistics show that the death toll of diabetes and its complications even exceeds the sum of AIDS, tuberculosis and malaria. Curbing the global spread of diabetes has become an important topic in the 21st century. [0003] Blood s...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): G01N27/327
Inventor 熊宇杰吴思凯
Owner UNIV OF SCI & TECH OF CHINA
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