Traditional Chinese medicine composition for preventing and treating rheumatoid arthritis and preparation method thereof

A composition and arthritis technology, which is applied in the field of traditional Chinese medicine composition for preventing and treating rheumatoid arthritis and its preparation, can solve the problems of slow effect and long treatment time, and achieve slow and irregular absorption, less harsh process conditions, Good biocompatibility effect

Active Publication Date: 2017-09-29
LIAONING UNIV OF TRADITIONAL CHINESE MEDICINE
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  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, most of the traditional Chinese medicine external preparations for the treatment of RA are ointment and patc

Method used

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  • Traditional Chinese medicine composition for preventing and treating rheumatoid arthritis and preparation method thereof
  • Traditional Chinese medicine composition for preventing and treating rheumatoid arthritis and preparation method thereof
  • Traditional Chinese medicine composition for preventing and treating rheumatoid arthritis and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Example Embodiment

[0050] Example 1

[0051] Weigh 6 grams of Eucommia, 6 grams of Sangji, 7 grams of Wei Lingxian, 6 grams of Salvia miltiorrhiza, 5 grams of Dilong, 8 grams of Shengdi, 6 grams of papaya, 6 grams of Wushao Snake, 5 grams of Panax notoginseng, 5 grams of Duhuo, 5 grams of safflower, 6 grams of white peony root, 6 grams of Scutellaria, 7 grams of angelica, and 3 grams of centipede.

[0052] Step 2. Preparation of alcohol extract

[0053]The weighed Paeonia lactiflora, Eucommia ulmoides, Wei Lingxian, Mulberry parasite, Salvia miltiorrhiza, Panax notoginseng, Duhuo, and safflower were soaked in 75% ethanol, and then refluxed at 90 °C for 3 times to obtain an alcohol extract, which was refluxed three times with 75% ethanol. The added amounts are: the first time is 8 times the weight of the total weight of Baishao, Eucommia, Wei Lingxian, Sangji, Salvia, Panax notoginseng, Duhuo, and safflower, and the second time is 8 times the sum of the above-mentioned masses. , the third time ...

Example Embodiment

[0060] Example 2.

[0061] 1. Investigation of the therapeutic activity of the traditional Chinese medicine composition of the present invention.

[0062] 1) Animal grouping and establishment of adjuvant arthritis rat model.

[0063] After 2 weeks of adaptive feeding of SD rats, 10 rats were randomly selected as the normal control group, and the rest were used for modeling. After fasting for 12 h, except for the normal control group, the rest of the rats were placed in cold water at 4°C-8°C, with a water surface height of 2 cm, taken out after 30 min, the rat body was blown dry by an electric fan, and then the right hind foot pad of the rat was placed. 0.1 ml of Freund's complete adjuvant was injected intradermally, and rats in the normal group were injected with an equal volume of normal saline for 2 consecutive days. Nine days after the inflammation, the left hind paw of the rats showed secondary arthritis symptoms (non-inflammatory and red and swollen joints of both forel...

Example Embodiment

[0080] Example 3.

[0081] Comparison of the therapeutic effects of different dosage forms on cotton ball granuloma in rats with adjuvant arthritis.

[0082] The inventors conducted a comparative study on the therapeutic effects of the traditional Chinese medicine composition gel and ointment of the present invention on cotton ball granuloma in rats with adjuvant arthritis.

[0083] The components in Example 1 were pulverized, sieved through a 120-mesh sieve, mixed with the fine powder, and then added with rice wine, stirred into a paste, and a paste mixture was obtained, wherein every 100 g of the paste mixture contained 30 g of the traditional Chinese medicine composition. The obtained mixture is evenly smeared on the plaster to obtain the plaster of the present invention.

[0084] Forty rats were randomly divided into normal control group, model control group, traditional Chinese medicine gel group and traditional plaster group. The construction method and administration ...

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Abstract

The invention provides a traditional Chinese medicine composition for preventing and treating rheumatoid arthritis and a preparation method thereof. The traditional Chinese medicine composition is prepared from the following components in parts by mass: 5-7 parts of eucommia ulmoides, 5-7 parts of loranthus parasiticus, 6-8 parts of radix clematidis, 5-7 parts of salviae miltiorrhizae, 4-6 parts of earthworm, 7-9 parts of radix rehmanniae recen, 5-7 parts of pawpaw, 5-7 parts of zaocys dhumnade, 4-6 parts of pseudo-ginseng, 4-6 parts of radix angelicae pubescentis, 4-6 parts of safflower carthamus, 5-7 parts of radix paeoniae alba, 5-7 parts of spatholobus suberctu, 6-8 parts of angelica sinensis and 2.5-3.5 parts of centipedes. The traditional Chinese medicine composition can be used for effectively treating rheumatoid arthritis inshort treatment time. A gel-type preparation prepared from the traditional Chinese medicine composition has a better treatment effect than that of conventional paste and patch, and can act on skin, mucous membranes and tracts, so that first pass elimination caused by oral administration can be avoided, and slow and irregular absorption and other defects and adverse response, such as allergy and rash, generated in the applying process in traditional paste can be relieved. The traditional Chinese medicine composition has the advantages of being convenient and comfortable in use, good in biocompatibility, non-strict in process condition and the like, is suitable for production condition of traditional Chinese medicinal compound preparations, is convenient for popularization and application, and can be used as first choice for improving traditional external preparations of traditional Chinese medicines.

Description

technical field [0001] The invention belongs to the field of traditional Chinese medicine preparations, and in particular relates to a traditional Chinese medicine composition for preventing and treating rheumatoid arthritis and a preparation method thereof. Background technique [0002] Rheumatoid arthritis (RA) is a chronic, multisystemic, inflammatory autoimmune disease mainly involving peripheral joints. Its clinical manifestations are pain, swelling, and decreased function of the affected joints. The pathology is chronic synovitis, which erodes cartilage and bone and destroys joints. Muscles, myelin sheaths, and bursae of patients may also be affected, and multiple organs and systems such as skin, breathing, blood, nerves, kidneys, heart, and eyes may also be affected. Commonly used drugs for treatment are traditionally divided into non-steroidal anti-inflammatory drugs, disease-modifying anti-rheumatic drugs, glucocorticoids, and immunomodulators. [0003] Rheumatoi...

Claims

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Application Information

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IPC IPC(8): A61K36/804A61K9/06A61P19/02A61P29/00A61K35/648A61K35/62A61K35/583
CPCA61K9/0014A61K9/06A61K35/583A61K35/62A61K35/648A61K36/185A61K36/232A61K36/258A61K36/286A61K36/46A61K36/486A61K36/537A61K36/65A61K36/71A61K36/716A61K36/732A61K36/804A61K47/32A61K2236/331A61K2236/333A61K2236/39A61K2236/51A61K2300/00
Inventor 徐志立袁子民张明波康廷国陶新知王素娟梁晗业
Owner LIAONING UNIV OF TRADITIONAL CHINESE MEDICINE
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