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Traditional Chinese medicine composition for preventing and treating rheumatoid arthritis and preparation method thereof

A composition and arthritis technology, which is applied in the field of traditional Chinese medicine composition for preventing and treating rheumatoid arthritis and its preparation, can solve the problems of slow effect and long treatment time, and achieve slow and irregular absorption, less harsh process conditions, Good biocompatibility effect

Active Publication Date: 2017-09-29
LIAONING UNIV OF TRADITIONAL CHINESE MEDICINE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, most of the traditional Chinese medicine external preparations for the treatment of RA are ointment and patch at present, the treatment time is long, the effect is slow, and the side effects of allergies and rashes will occur

Method used

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  • Traditional Chinese medicine composition for preventing and treating rheumatoid arthritis and preparation method thereof
  • Traditional Chinese medicine composition for preventing and treating rheumatoid arthritis and preparation method thereof
  • Traditional Chinese medicine composition for preventing and treating rheumatoid arthritis and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0051] Weigh 6 grams of Eucommia ulmoides, 6 grams of Sangjisheng, 7 grams of Clematis, 6 grams of Salvia miltiorrhiza, 5 grams of Dilong, 8 grams of Shengdi, 6 grams of papaya, 6 grams of black snake, 5 grams of Panax notoginseng, 5 grams of Duhuo, 5 grams of safflower, 6 grams of white peony, 6 grams of Caulis Spatholobus, 7 grams of angelica, and 3 grams of centipede.

[0052] Step 2, preparation of alcohol extract

[0053]Add the weighed Radix Paeoniae Alba, Eucommia, Clematis, Sangjisheng, Salvia, Panax notoginseng, Duhuo, and safflower to 75% ethanol and soak them, then reflux and extract at 90°C for 3 times to obtain the alcohol extract, and reflux 75% ethanol three times The addition amounts are as follows: the first time is 8 times the sum of the weighed Radix Paeoniae Alba, Eucommia, Clematis, Sangjisheng, Salvia, Panax notoginseng, Duhuo, and safflower, and the second time is 8 times the sum of the above masses , the third time is 6 times of the above mass sum.

...

Embodiment 2

[0061] 1. Investigation of the therapeutic activity of the traditional Chinese medicine composition of the present invention.

[0062] 1) Animal grouping and establishment of adjuvant arthritis rat model.

[0063] After adaptive feeding of SD rats for 2 weeks, 10 SD rats were randomly selected as the normal control group, and the remaining rats were used for modeling. After fasting for 12 hours, except for the normal control group, the rest of the rats were placed in cold water at 4°C-8°C with a water surface height of 2 cm. After 30 minutes, the rats were taken out, and the rats were dried with an electric fan. Intradermal injection of Freund's complete adjuvant 0.1 ml / rat, normal group of rats injected with an equal volume of normal saline, continuous 2 days. Nine days after the inflammation, the left hind feet of the rats successively appeared secondary arthritis symptoms (non-inflammation and joint redness and swelling of both forelimbs), listlessness, and loose hair, ind...

Embodiment 3

[0081] Comparison of the therapeutic effects of different dosage forms on cotton ball granuloma in rats with adjuvant arthritis.

[0082] The inventor conducted a comparative study on the therapeutic effect of the traditional Chinese medicine composition gel and ointment of the present invention on cotton ball granuloma in rats with adjuvant arthritis.

[0083] The components in Example 1 were pulverized, sieved through a 120-mesh sieve, mixed with the fine powder, added to rice wine, and stirred into a paste to obtain a pasty mixture, wherein every 100 g of the pasty mixture contained 30 g of the traditional Chinese medicine composition. Apply the obtained mixture evenly on the plaster to obtain the plaster of the present invention.

[0084] 40 rats were randomly divided into normal control group, model control group, traditional Chinese medicine gel group and traditional plaster group. Adjuvant arthritis rat model construction method and administration method are the same a...

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Abstract

The invention provides a traditional Chinese medicine composition for preventing and treating rheumatoid arthritis and a preparation method thereof. The traditional Chinese medicine composition is prepared from the following components in parts by mass: 5-7 parts of eucommia ulmoides, 5-7 parts of loranthus parasiticus, 6-8 parts of radix clematidis, 5-7 parts of salviae miltiorrhizae, 4-6 parts of earthworm, 7-9 parts of radix rehmanniae recen, 5-7 parts of pawpaw, 5-7 parts of zaocys dhumnade, 4-6 parts of pseudo-ginseng, 4-6 parts of radix angelicae pubescentis, 4-6 parts of safflower carthamus, 5-7 parts of radix paeoniae alba, 5-7 parts of spatholobus suberctu, 6-8 parts of angelica sinensis and 2.5-3.5 parts of centipedes. The traditional Chinese medicine composition can be used for effectively treating rheumatoid arthritis inshort treatment time. A gel-type preparation prepared from the traditional Chinese medicine composition has a better treatment effect than that of conventional paste and patch, and can act on skin, mucous membranes and tracts, so that first pass elimination caused by oral administration can be avoided, and slow and irregular absorption and other defects and adverse response, such as allergy and rash, generated in the applying process in traditional paste can be relieved. The traditional Chinese medicine composition has the advantages of being convenient and comfortable in use, good in biocompatibility, non-strict in process condition and the like, is suitable for production condition of traditional Chinese medicinal compound preparations, is convenient for popularization and application, and can be used as first choice for improving traditional external preparations of traditional Chinese medicines.

Description

technical field [0001] The invention belongs to the field of traditional Chinese medicine preparations, and in particular relates to a traditional Chinese medicine composition for preventing and treating rheumatoid arthritis and a preparation method thereof. Background technique [0002] Rheumatoid arthritis (RA) is a chronic, multisystemic, inflammatory autoimmune disease mainly involving peripheral joints. Its clinical manifestations are pain, swelling, and decreased function of the affected joints. The pathology is chronic synovitis, which erodes cartilage and bone and destroys joints. Muscles, myelin sheaths, and bursae of patients may also be affected, and multiple organs and systems such as skin, breathing, blood, nerves, kidneys, heart, and eyes may also be affected. Commonly used drugs for treatment are traditionally divided into non-steroidal anti-inflammatory drugs, disease-modifying anti-rheumatic drugs, glucocorticoids, and immunomodulators. [0003] Rheumatoi...

Claims

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Application Information

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IPC IPC(8): A61K36/804A61K9/06A61P19/02A61P29/00A61K35/648A61K35/62A61K35/583
CPCA61K9/0014A61K9/06A61K35/583A61K35/62A61K35/648A61K36/185A61K36/232A61K36/258A61K36/286A61K36/46A61K36/486A61K36/537A61K36/65A61K36/71A61K36/716A61K36/732A61K36/804A61K47/32A61K2236/331A61K2236/333A61K2236/39A61K2236/51A61K2300/00
Inventor 徐志立袁子民张明波康廷国陶新知王素娟梁晗业
Owner LIAONING UNIV OF TRADITIONAL CHINESE MEDICINE
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