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Preparation method of mesoporous silica/titania nanotube array composite

A technology of mesoporous silica and nanotube arrays, applied in metal material coating process, electrolytic coating, liquid chemical plating, etc., can solve the problems such as unable to fully meet clinical needs, difficult to form bone bonding, etc. Facilitates growth and adhesion, promotes bioavailability, good stability

Active Publication Date: 2017-10-10
FUJIAN NORMAL UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, because it is difficult to form a relatively strong bone bond with bone tissue after implantation in the human body, it still cannot fully meet the clinical needs.

Method used

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  • Preparation method of mesoporous silica/titania nanotube array composite
  • Preparation method of mesoporous silica/titania nanotube array composite
  • Preparation method of mesoporous silica/titania nanotube array composite

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0025] With titanium metal as the substrate, it was polished to smooth with metallographic sandpaper, ultrasonically cleaned in acetone and cleaned in 4wt%HF-5mol / LHNO 3 etched in a mixed acid solution, rinsed with distilled water, ultrasonicated, and dried at 50°C to obtain the treated titanium sheet. With the pretreated titanium sheet as the anode and the platinum sheet as the cathode, 0.50wt% NH 4 +10wt%H 2 O+glycerol is the electrolyte solution, in which the mass ratio of glycerol (glycerol) to water is 9:1. After anodizing at 60V for 24 hours, take it out, rinse it with distilled water, and dry it in the air to get titanium dioxide nanoparticles. tube array, the microscopic topography is shown in figure 1 As shown, the nanotubes are closely arranged and regular, and the diameter of the tube is about 210nm.

[0026] Dissolve 5.60mmol of dodecyltrimethylammonium bromide in 122ml of distilled water, then add 8g of 25wt% NH 3 ·H 2 O, stir for 10 min. Add 10.0 g tetraeth...

Embodiment 2

[0029] With titanium metal as the substrate, it was polished to smooth with metallographic sandpaper, ultrasonically cleaned in acetone and cleaned in 4wt%HF-5mol / LHNO 3 etched in a mixed acid solution, rinsed with distilled water, ultrasonicated, and dried at 50°C. With the pretreated titanium sheet as the anode and the platinum sheet as the cathode, 0.50wt% NH 4 F+10wt%H 2 O+glycerol is the electrolyte solution, in which the mass ratio of glycerol (glycerol) to water is 9:1. After anodizing at 60V for 24 hours, take it out, rinse it with distilled water, and dry it in the air to get titanium dioxide nanoparticles. tube array, the microscopic topography is shown in figure 1 As shown, the nanotubes are closely arranged and regular, and the diameter of the tube is about 210nm.

[0030]Dissolve 5.60mmol of cetyltrimethylammonium bromide in 122ml of distilled water, then add 8g of 25wt%NH 3 ·H 2 O, stir for 10 min. Add 10.0 g tetraethyl orthosilicate (TEOS) while stirring, ...

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Abstract

The invention discloses a preparation method of a novel mesoporous silica nano particle / titania nanotube array composite. The method is characterized by comprising the following steps that (1) a titanium sheet is used as an anode, and a titania nanotube array is prepared through anodizing; (2) mesoporous silica nano particles are prepared through a sol-gel method; and (3) the anodized titania nanotube array obtained in the step (1) is placed in dispersion liquid of the mesoporous silica nano particles obtained in the step (2) for hydrothermal reaction, and the surface of the titania nanotube array is modified with the mesoporous silica nano particles. The method has the characteristics that the mesoporous silica nano particles are penetrated into the titania nanotube array, the bonding strength is high, and a composite support has good stability; and the composite has biological activity, some pharmaceutical molecules can be loaded, and the composite can be used as a slow release support for medicines.

Description

technical field [0001] The invention belongs to the field of drug slow-release carriers and bone repair biomaterials, and in particular relates to a method for preparing a novel composite material of mesoporous silica nanoparticle / titanium dioxide nanotube array. Background technique [0002] Implant materials with good biological properties have been widely used in orthopedic surgery. For built-in materials, good biocompatibility is the first requirement. Titanium and titanium alloys have excellent mechanical properties, corrosion resistance and good biocompatibility, and are widely used in orthopedics and stomatology. However, because it is difficult to form a relatively firm bone bond with bone tissue after it is implanted in the human body, it still cannot fully meet the clinical needs. [0003] Constructing titanium dioxide nanotube arrays on the surface of titanium metal implants can not only effectively improve the biocompatibility of titanium metal implants, promot...

Claims

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Application Information

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IPC IPC(8): C25D11/26C23C18/12
CPCC23C18/1212C23C18/1254C25D11/26
Inventor 谢春玲陈顺玉肖秀峰
Owner FUJIAN NORMAL UNIV
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