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Preparation method of bioactive glass composite material

A technology of bioactive glass and composite materials, applied in the field of preparation of bioactive glass composite materials, can solve the problems of low mechanical strength, poor resistance to enzymatic hydrolysis, low mineralization activity, etc., to maintain mechanical properties, improve degradation ability, The effect of fast mineralization

Inactive Publication Date: 2017-11-03
江苏华友装饰工程有限公司
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  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] The technical problem to be solved by the present invention: Aiming at the problems of low mechanical strength, poor resistance to enzymolysis and low mineralization activity of traditional bioglass, a preparation method of bioactive glass composite material is provided

Method used

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  • Preparation method of bioactive glass composite material

Examples

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Effect test

example 1

[0022] In parts by weight, respectively select 70 parts of absolute ethanol, 5 parts of deionized water, and 2 parts of ammonia water into a beaker, stir and mix for 20 minutes to obtain a mixed solution, add 3% calcium nitrate of the mixed solution to the beaker, stir for 20 minutes and use The mass fraction is 15% ammonia water to adjust the pH to 9.5, and after adjustment, the material is discharged to obtain the adjustment solution; according to the mass ratio of 3:1, the adjustment solution and ethyl orthosilicate are mixed, stirred until a white precipitate appears, and the precipitate is collected after centrifugation. The precipitate was washed twice with acetone, then put into an oven, dried at 60°C for 6 hours, put into a tube furnace after drying, raised to 500°C at a heating rate of 10°C / min, kept for 40 minutes, and then cooled to room temperature. and discharging to obtain bioactive glass; by parts by weight, respectively select 10 parts of wormwood, 5 parts of ca...

example 2

[0024] In parts by weight, respectively select 75 parts of absolute ethanol, 8 parts of deionized water, and 3 parts of ammonia water into a beaker, stir and mix for 25 minutes to obtain a mixed solution, add mixed solution quality 4% calcium nitrate in the beaker, stir for 25 minutes and use The mass fraction is 15% ammonia water to adjust the pH to 9.8, and discharge the material after adjustment to obtain the adjustment solution; according to the mass ratio of 3:1, mix the adjustment solution and ethyl orthosilicate, stir until white precipitate appears, collect the precipitate after centrifugation, and The precipitate was washed 3 times with acetone, then put into an oven, dried at 70°C for 8 hours, put into a tube furnace after drying, raised to 525°C at a heating rate of 13°C / min, kept for 45 minutes, and then cooled to room temperature. and discharging to obtain bioactive glass; by weight parts, respectively select 13 parts of wormwood, 7 parts of cattail grass, 10 parts...

example 3

[0026]In parts by weight, respectively select 80 parts of absolute ethanol, 10 parts of deionized water, and 4 parts of ammonia water into a beaker, stir and mix for 30 minutes to obtain a mixed solution, add 5% calcium nitrate of the mixed solution in the beaker, stir for 30 minutes and use The mass fraction is 15% ammonia water to adjust the pH to 10.0, and discharge the material after adjustment to obtain the adjustment liquid; according to the mass ratio of 3:1, mix the adjustment liquid and tetraethyl orthosilicate, stir until a white precipitate appears, collect the precipitate after centrifugation, and The precipitate was washed 4 times with acetone, then put into an oven, dried at 80°C for 10 hours, put into a tube furnace after drying, raised to 550°C at a heating rate of 15°C / min, kept for 50 minutes, and then cooled to room temperature. and discharging to obtain bioactive glass; by parts by weight, respectively select 15 parts of wormwood, 10 parts of cattail grass, ...

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Abstract

The invention relates to a preparation method of a bioactive glass composite material, and belongs to the technical field of medical materials. The preparation method comprises the following steps: performing reaction on a silk fibroin solution and gelatin, adding bioactive glass dispersing liquid and glutamine transaminase after the reaction, and performing crosslinking reaction under the condition that the glutamine transaminase serves as a catalyst to obtain viscous liquid; and pouring the viscous liquid into a mold, and molding, gelatinizing, ageing and freeze-drying to obtain the bioactive glass composite material. The bioactive glass composite material prepared by the method has high biocompatibility, maintains high mechanical property, has high mineralizing speed, is an ideal tissue material and can be applied to defect regeneration and repair of human bones.

Description

technical field [0001] The invention relates to a preparation method of a bioactive glass composite material, which belongs to the technical field of medical materials. Background technique [0002] In recent years, there are more and more medical records of bone defects caused by trauma, tumor resection, infection and abnormal development in clinical practice; there is still no ideal treatment for bone defect repair, especially for large-area and complex-shaped bone defects. Therefore, it is urgent to study bone defects and bone repair materials. Among many bone substitute materials, compared with HA, bioactive glass materials have higher HA formation activity, higher osseointegration strength, better degradability, and can directly promote the transformation of stem cells into osteoblasts. Induction. [0003] Bioactive glass has good biological activity. When it is implanted in the body, a layer of HCA can be generated on the surface of the bioactive glass. HCA is very c...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L27/22A61L27/36A61L27/10A61L27/50
CPCA61L27/10A61L27/222A61L27/227A61L27/36A61L27/50A61L2430/02C08L89/00
Inventor 吴义峰陈春
Owner 江苏华友装饰工程有限公司
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