A kind of gold nanostar/calcium phosphate nanoparticle and preparation method thereof
A nanoparticle, calcium phosphate technology, applied in nanocomposite materials and their application fields, can solve problems such as affecting the activity of innate immune cells
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Embodiment 1
[0021] Example 1 Preparation method of monodisperse gold nanostar / calcium phosphate composite structure nanoparticles
[0022] Take 5mL HAuCl 4 (30 mM) solution, 10 mg calcium hydroxide, 8 mg sodium hydroxide and 20 mg polyacrylic acid were successively added to 25 mL deionized water, and stirred evenly until the solution was clear. Then, 50 mL of isopropanol was slowly added dropwise to the solution under magnetic stirring, and then 100 μL (3 mM) of silver nitrate aqueous solution and 50 μL (0.1M) of ascorbic acid aqueous solution were added to the solution after the dropwise addition was completed. o The reaction was stirred at C for 2 h. Then, 10 mg diammonium hydrogen phosphate was added to the solution, stirred at room temperature for 12 h, and then the solution was centrifuged (6000 rpm, 8 min), and the obtained solid was washed several times with deionized water to obtain gold nanostars / Calcium phosphate composite structure nanoparticles.
Embodiment 2
[0023] Example 2 The preparation method of monodisperse gold nanostar / calcium phosphate composite structure nanoparticles
[0024] Take 8mL HAuCl 4 (30 mM) solution, 20 mg calcium hydroxide, 8 mg sodium hydroxide and 40 mg polyacrylic acid were successively added to 35 mL deionized water, and stirred evenly until the solution was clear. Then, 50 mL of isopropanol was slowly added dropwise to the solution under magnetic stirring, and then 200 μL (3 mM) of silver nitrate aqueous solution and 10 μL (0.1M) of ascorbic acid aqueous solution were added to the solution after the dropwise addition was completed. o The reaction was stirred at C for 2 h. Then, 20 mg diammonium hydrogen phosphate was added to the solution, stirred at room temperature for 15 h, and then the solution was centrifuged (8000 rpm, 8 min), and the obtained solid was washed several times with deionized water to obtain gold nanostars / Calcium phosphate composite structure nanoparticles.
Embodiment 3
[0025] Example 3 Preparation method of monodisperse gold nanostar / calcium phosphate composite structure nanoparticles
[0026] Take 7mL HAuCl 4 (30 mM) solution, 15 mg calcium hydroxide, 8 mg sodium hydroxide and 20 mg polyacrylic acid were successively added to 25 mL deionized water, and stirred evenly until the solution was clear. Then, 50 mL of isopropanol was slowly added dropwise to the solution under magnetic stirring, and then 100 μL (3 mM) of silver nitrate aqueous solution and 50 μL (0.1M) of ascorbic acid aqueous solution were added to the solution after the dropwise addition was completed. o The reaction was stirred at C for 3 h. Then, 15 mg diammonium hydrogen phosphate was added to the solution, stirred at room temperature for 12 h, and then the solution was centrifuged (7000 rpm, 6 min), and the obtained solid was washed several times with deionized water to obtain gold nanostars / Calcium phosphate composite structure nanoparticles.
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