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Application of Xiyanping injection for preparation of drugs for treating and/or preventing neurodegenerative disease

A neurodegenerative and injection technology, which is applied in the direction of nervous system diseases, drug delivery, drug combination, etc., can solve the problems of no neurodegenerative disease drugs, impurity quality control that cannot meet more precise requirements, and difficulty in preparing liquid preparations, etc.

Inactive Publication Date: 2017-11-24
JIANGZI QINGFENG PHARMACEUTICALS INC
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0008] However, the application of andrographolide is still in the development stage, especially the "andrographolide injection" has not been widely used.
The main reason is that andrographolide is soluble in methanol, ethanol, propanol, pyridine, slightly soluble in chloroform, ether, but because andrographolide is insoluble in water, it brings difficulties to the preparation of liquid preparations
Although at present, some methods have been used to convert andrographolide into various derivatives, for example, after extracting andrographolide, it is generally prepared into injections of various water-soluble derivatives, such as adding sulfuric acid with sodium sulfite or with sodium bisulfite Addition reaction occurs, and the prepared water-soluble sulfonate, sodium bisulfite andrographolide (Lianbizhi injection), but the solubility and stability of the above-mentioned salt in water are not particularly good
In addition, quality control such as impurities in its production process cannot meet more precise requirements
[0009] Therefore, it is currently recognized in the art that due to the water-insoluble characteristics of andrographolide and the limitation of current production process conditions, "andrographolide injection or solution" is only used for general inflammation or antiviral purposes. Does not meet the conditions for application in neurodegenerative disease drugs
[0010] Through the search, there is currently no information about "the application of andrographolide injection for the preparation of drugs for the prevention and treatment of neurodegenerative diseases" or "the application of andrographolide derivative injection for the preparation of drugs for the prevention and treatment of neurodegenerative diseases" Applications in "related reports
Moreover, the "andrographolide or andrographolide derivatives" mentioned in the above-mentioned patents are currently unable to realize "injections" in the industry, and it is even more impossible to give any technical inspiration to make those skilled in the art think that they can be used in the above-mentioned patents. Based on "Application of Formed Injections for the Prevention and Treatment of Neurodegenerative Diseases"
[0011] Through further searching, there is currently no information about "the application of andrographolide sulfonate injection for the preparation of drugs for the prevention and treatment of neurodegenerative diseases" or "andrographolide sulfonate derivatives and / or its mixture injection for use in Application in the preparation of drugs for the prevention and treatment of neurodegenerative diseases" related reports

Method used

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  • Application of Xiyanping injection for preparation of drugs for treating and/or preventing neurodegenerative disease
  • Application of Xiyanping injection for preparation of drugs for treating and/or preventing neurodegenerative disease
  • Application of Xiyanping injection for preparation of drugs for treating and/or preventing neurodegenerative disease

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0043] Example 1: Therapeutic Effect of Xiyanping Injection on APP / PS1 Alzheimer's Disease Mice

[0044] 1. Materials and methods

[0045] 1.1 Experimental animals and drugs

[0046] In this experiment, APP / PS1 male mice and littermate wild-type mice were selected and raised in a quiet environment with room temperature (22°C-24°C), humidity (50%-60%), and 12 hours of light and dark time each day. , free access to food and water. Before the experiment, the animals were acclimated to the experimental environment for 3 days.

[0047] Xiyanping injection was purchased from Jiangxi Qingfeng Pharmaceutical Co., Ltd., and formulated into 2.5mg / kg and 5mg / kg doses.

[0048] 1.2 Animal grouping and administration

[0049] After weighing, the mice were randomly divided into wild type, wild type administration group, APP / PS1 model group, APP / PS1 Xiyanping 2.5 mg / kg and 5 mg / kg treatment groups, with 5 mice in each group.

[0050] 1.3 Behavioral testing

[0051] 1.3.1 Water maze exp...

Embodiment 2

[0078] Example 2: The therapeutic effect of Xiyanping injection on MPTP-induced Parkinson's disease in mice

[0079] 1. Materials and methods

[0080] 1.1 Experimental animals and drugs

[0081] This experiment selects 10-12 week old 25-28g healthy male C57Bl / 6 mice, the mouse is at room temperature (22 ℃-24 ℃), humidity (50%-60%), daily light and dark time each 12h Raised in a quiet environment, free access to food and water. Before the experiment, the animals were acclimated to the experimental environment for 3 days.

[0082] MPTP was purchased from Sigma, and levodopa was purchased from Roche Pharmaceuticals. MPTP was prepared with normal saline within 30 minutes before administration, and stored on ice. Xiyanping injection was purchased from Jiangxi Qingfeng Pharmaceutical Co., Ltd., and was formulated at 5% and 10% administration concentrations, and 0.1ml was injected intraperitoneally into 20g mice .

[0083] 1.2 Animal grouping and administration

[0084] After w...

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Abstract

The invention discloses application of a Xiyanping injection for preparation of drugs for treating and / or preventing the neurodegenerative disease. Through experimental data, it can be known that the Xiyanping injection better improves the learning and memory capability of AD mice, in conclusion, the good improving effect is achieved on the mouse Parkinson's disease, and compared with the levodopa, side effects are avoided; and thus, the new application and action mechanisms are provided for drug repurposing of the Xiyanping injection, new prospects are developed for clinical application of the Xiyanping injection, and the Xiyanping injection is capable of achieving mass production in industry, capable of being applied to clinic and is remarkable in effect. Under the precondition that medical and pharmaceutical researchers do not perform relevant experiments, the medical and pharmaceutical researchers cannot know that the Xiyanping injection has good application in preparation of the drugs for treating and / or preventing the neurodegenerative disease in advance.

Description

technical field [0001] The invention relates to the application of Xiyanping injection in the preparation of medicines for treating and / or preventing neurodegenerative diseases. Background technique [0002] Neurodegenerative diseases are diseases caused by central nervous system dysfunction caused by progressive degeneration and necrosis of nerve cells, which are aggravated with the aging of the global population, including Alzheimer's disease (AD) and Parkinson's disease (Parkinson's disease, PD), amyotrophic lateral sclerosis (Atrophy lateral sclerosis, ALS), Huntington's disease (Huntington's disease, HD), stroke (Stroke) and cardiovascular dementia (Vascular dementia, VD). It mainly affects the cognitive function and motor function of patients, causing disability and high mortality rate, and brings great psychological and economic burden to patients' families and society. [0003] Among them, Alzheimer's disease (AD) is a neurodegenerative disease characterized by prog...

Claims

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Application Information

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IPC IPC(8): A61K31/365A61K9/08A61P25/28A61P25/16A61P9/10
CPCA61K9/0019A61K9/08A61K31/365
Inventor 黄冰峰唐春山胡晓强邱小燕殷华峰罗恒真曾君南简蓝丁邑强
Owner JIANGZI QINGFENG PHARMACEUTICALS INC
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