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Preparation method of composite preparation for preventing and treating poultry respiratory diseases

A compound preparation and respiratory technology, applied in the direction of respiratory diseases, antiviral agents, medical preparations containing active ingredients, etc., can solve the problems of poor clinical immune prevention effect and no specific drugs for treatment, and achieve the prevention of infectious bronchial inflammation, reduce drug residues, and ensure safety

Inactive Publication Date: 2017-11-24
JIANGSU AGRI ANIMAL HUSBANDRY VOCATIONAL COLLEGE
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  • Abstract
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  • Application Information

AI Technical Summary

Problems solved by technology

[0007] Due to the large number of serotypes of poultry respiratory diseases, the clinical immune prevention effect is not good, and there is no specific drug for treatment

Method used

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  • Preparation method of composite preparation for preventing and treating poultry respiratory diseases

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0032] Embodiment 1: the extract of Chinese veterinary medicine and powder preparation

[0033] The inventor screened and clinically verified the traditional Chinese veterinary medicines for the treatment of poultry respiratory diseases, and determined that the basic prescription is Yemazhui, and the most preferred ones are Yemazhui, Banlangen, Ephedra, Campanulaceae, Andrographis paniculata, Houttuynia cordata, Astragalus, Tinglizi and Poria cocos The mass ratio is 1 to 10:1:1:1:1:1:1:1:1. The Chinese veterinary medicine extract was prepared by concentrating and extracting the ingredients of traditional Chinese medicine by using ultrasonic technology and vacuum freeze-drying technology.

[0034] After drying Yemachai, pulverize it with a micro pulverizer and mix it, place it in a stoppered conical flask, add 5 times the volume of extraction solvent ethyl acetate, and then use ultrasonic waves to extract its active ingredients. The soaking time before extraction is 60- 90mi...

Embodiment 2

[0038] Embodiment 2: the development of chicken egg yolk immunoglobulin powder

[0039] Select healthy laying hens, and use commercial or self-made monovalent or multivalent vaccines for respiratory pathogenic microorganisms (such as Newcastle disease-infectious bronchitis-avian influenza triple inactivated vaccine or Newcastle disease-infectious bursa-infectious bronchitis triple vaccine) Vaccine) Inject multi-point injections into the breast muscles of laying hens, 0.5mL / hen, and immunize once a week. After three immunizations, the immunoglobulin level reaches a high titer, and the eggs are collected.

[0040] Extract yolk immunoglobulin (taking the acetic acid-sodium acetate buffer method as an example), the eggs are first washed with water to remove the dirt on the surface of the eggshell, immersed in 0.5% bromogeramine solution, soaked for 10 minutes, and then rinsed with 75% alcohol, Aseptically break the eggshell, pour it into a sterilized container, separate the egg ...

Embodiment 3

[0043] Example 3: Optimum ratio selection of Chinese veterinary drug egg yolk immunoglobulin compound preparation

[0044] According to different ratios, the optimal ratio of Chinese veterinary medicine and chicken egg yolk immunoglobulin was studied.

[0045] According to a completely random design, 200 5-week-old unimmunized AA broiler roosters were randomly divided into 4 test groups and 1 control group according to body weight, with 40 chickens in each group. According to the different proportions (mass ratio) of the Chinese veterinary medicine extract powder described in Example 1 and the egg yolk immunoglobulin described in Example 2, they were divided into test groups I, II, III and IV, and the proportions were 1:1 respectively. , 1:0.8, 1:0.5, 1:0.2. Each chicken in the test group was fed with 1.5ml of the aqueous solution of the Chinese veterinary drug egg yolk immunoglobulin compound preparation every day, and the control group was fed with 1.5ml of normal saline ...

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Abstract

The invention provides a preparation method of a traditional Chinese veterinary medicine yolk immunoglobulin composite preparation for preventing and treating poultry respiratory diseases. The method comprises the following steps: a, preparing traditional Chinese veterinary medicine powder or traditional Chinese veterinary medicine extract powder; b, preparing yolk immunoglobulin powder; c, mixing the powder in the step a and the step b according to a mass ratio of 1:1. A traditional Chinese veterinary medicine includes but is not limited to lindley eupatorium herb, radix isatidis, herba ephedrae, radix platycodi, common andrographis herb, herba houttuyniae, radix astragali seu hedysari, lepidium seed and poria cocos. The yolk immunoglobulin powder is obtained by immunizing laying hens by market sold or self-made respiratory tract pathogenic microorganism monovalent or multivalent vaccines (such as Newcastle disease-infectious bronchitis-bird flu triple inactivated vaccines or Newcastle disease-infectious bursal diseases-infectious bronchitis triple vaccines).

Description

technical field [0001] The invention relates to the field of veterinary medicine and feed additives, in particular to a preparation method of a compound preparation for preventing and treating poultry respiratory diseases. Background technique [0002] Chicken upper respiratory tract infection refers to the disease caused by the invasion of pathogenic microorganisms in the upper respiratory tract of chickens. Common respiratory diseases in chickens are mainly caused by viruses, bacteria, and mycoplasma septicemia. The main clinical features are tearing, runny nose, cough, wheezing, rales, dyspnea, and eye swelling. Infectious laryngotracheitis and infectious bronchitis (caused by coronavirus is an infectious bronchitis virus) are common. The disease mostly occurs from March to June in spring. The disease spreads quickly and the infection rate is high. The mortality rate is related to the environment, Management is related to the individual health status of chickens. General...

Claims

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Application Information

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IPC IPC(8): A61K39/42A61P11/00A61P31/04A61P31/12A61K36/28A61K36/78
Inventor 王冬梅钱峰方希修
Owner JIANGSU AGRI ANIMAL HUSBANDRY VOCATIONAL COLLEGE
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