Preparation method of spiral implantable minimally-invasive glucose sensor with PVA (polyvinyl alcohol)/PEG (polyethylene glycol) composite hydrogel outer membrane structure

Abstract

The invention provides a preparation method of a spiral implantable minimally-invasive glucose sensor with a PVA (polyvinyl alcohol) / PEG (polyethylene glycol) composite hydrogel outer membrane structure. A spiral platinum-iridium alloy electrode is selected, the biocompatibility and the interference resistance of the implantable sensor are improved by coating an Epoxy-PU (polyurethane) semi-permeable membrane and a hydrogel outer membrane, and the influence of different proportions of PVA / PEG on the performance of the glucose sensor is focused. Besides, the sensor has controllable sensitivity and good repeatability, stability and selectivity, and a solid foundation is laid for practicability of a future continuous glucose monitoring sensor.

Description

technical field [0001] The invention relates to the technical field of biosensors, in particular to a preparation method of a helical implantable minimally invasive glucose sensor with a PVA / PEG composite hydrogel outer membrane structure. Background technique [0002] Diabetes History One of the most important chronic diseases currently threatening human health worldwide, the main cause is the failure of pancreatic beta cells responsible for secreting insulin, resulting in the inability to strictly control the level of glucose in the blood. Diabetes can induce hypertension, cardiovascular, renal failure, hand and foot necrosis, nervous disorders and other diseases, which are extremely harmful to human life and health; according to the statistics of the International Diabetes Federation (IDF), it is estimated that by 2030, there will be nearly 5.5 Hundreds of millions of people suffer from diabetes, among which in my country, the total number of patients with type I diabetes ...

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Problems solved by technology

[0002] Diabetes History One of the most important chronic diseases currently threatening human health worldwide, the main cause is the malfunction of pancreatic beta cells responsible for secreting insulin, resulting in the inability to strictly control the level of glucose in the blood

Diabetes can induce hypertension, cardiovascular, renal failure, hand and foot necrosis, nervous disorders and other diseases, which are extremely harmful to human life and health; according to the statistics of the International Diabetes Federation (IDF), it is estimated that by 2030, there will be nearly 5.5 Hundreds of millions of people suffer from diabetes, among which in my country, the total number of patients with type I diabetes is between 7 and 10 million; in order to maintain close to normal blood sugar levels (70-120mg / dL), currently diabetics are widely using hand-held blood glucose meters, Requires several finger pricks per day to obtain blood samples, which can be painful and inconvenient for patients, and does not allow for continuous monitoring of glucose levels in the body

[0003] The products currently researched and sold on the market are mainly needle-shaped glucose electrodes, which have attracted widespread attention because of their easy-to-manufacture and suitability for implantation, such as the ultra-microporous polyurethane-coated needle-shaped implantable glucose electrode designed by Ahyeon Koh et al. sensor, but its disadvantages are also obvious: the GOD load is too low, resulting in a short service life; in order to solve such problems, helical glucose sensors have been reported; for example, the coil sensor made by Yμ et al. Constant polarization can still function well after 3 months, but it begins to lose its sensitivity after implantation in the body; biocontamination and rejection caused by implantation damage of the glucose sensor will eventually lead to sensor failure, and the sensor is in the Gradual loss of function after implantation, mainly due to the body's foreign body response (FBR) caused by the periwound tissue after implantation, including fibrous capsule and inflammatory response; in order to improve the life of the implanted glucose sensor, it has a biocompatible coating Materials such as: silica-based composites, sol-gel coatings, diamond-like carbon films, nanoporous anode aluminum films, etc. However, the outer coating of the glucose sensor must be stable in the organism to ensure the transport of glucose in the sensor, reduce the deposition of proteins and other interfering substances and minimize the fibrous envelope.

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