Magnesium alloy biological implant material and preparation method thereof

An implant material, magnesium alloy technology, applied in the field of magnesium alloy biological implant materials and its preparation, can solve problems such as narrow lumen, achieve refinement and uniform distribution, increase nucleation rate, remove impurities and purify the melt Effect

Inactive Publication Date: 2017-12-05
TAIYUAN UNIV OF TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Especially in the implantation of stents in infants and young children, due to the permanent presence of implanted metal substances, the diameter of blood vessels there is inhibited from increasing with age, and it is easy to induce restenosis of the lumen

Method used

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  • Magnesium alloy biological implant material and preparation method thereof

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Experimental program
Comparison scheme
Effect test

Embodiment 1

[0035]In the present embodiment, raw material composition is as follows: Zn2.00%, Ca 0.4%, Zr 0.4%, all the other are Mg and contain a small amount of impurity element Fe, Ni, Al, Cu, impurity element is calculated by mass percentage, each content is different Exceeding 0.1%, the total amount shall not exceed 0.4%.

[0036] The preparation method of magnesium alloy in the present embodiment is as follows:

[0037] First, use ZnO and talcum powder paint to evenly brush the inner wall of the self-made non-magnetic stainless steel crucible to white, and preheat the slag removal spoon, stirring spoon, and mold to 200°C; then when the furnace temperature rises to 400°C, put 500g magnesium block Put it into the crucible and continue to heat up to 710°C, keep it warm for 15 minutes to melt the magnesium block; remove the slag when the temperature drops to 700°C, and add 10.48g of Zn block; Add 6.81gMg-30wt.%Ca master alloy and 6.81g Mg-30wt.%Zr master alloy at the same time, stir ge...

Embodiment 2

[0042] In the present embodiment, the raw material composition is as follows: Zn6.00%, Ca 0.7%, Zr 0.6%, all the other are Mg and contain a small amount of impurity elements Fe, Ni, Al, Cu, impurity elements are calculated by mass percentage, each content is different Exceeding 0.1%, the total amount shall not exceed 0.4%.

[0043] The preparation method of magnesium alloy in the present embodiment is as follows:

[0044] First, use ZnO and talcum powder paint to evenly brush the inner wall of the self-made non-magnetic stainless steel crucible to white, and preheat the slag removal spoon, stirring spoon, and mold to 205°C; then when the furnace temperature rises to 420°C, put 500g magnesium block Put it into the crucible and continue to heat up to 720°C, keep it warm for 20 minutes to melt the magnesium block; remove the slag when the temperature drops to 705°C, and add 33.5g of Zn block; Add granular Mg-30wt.%Ca master alloy and 11.2gMg-30wt.%Zr master alloy at the same tim...

Embodiment 3

[0049] In the present embodiment, raw material composition is as follows: Zn3.00%, Ca 0.3%, Zr 0.3%, all the other are Mg and contain a small amount of impurity element Fe, Ni, Al, Cu, impurity element is calculated by mass percentage, each content is different Exceeding 0.1%, the total amount shall not exceed 0.4%.

[0050] The preparation method of magnesium alloy in the present embodiment is as follows:

[0051] First, paint the inner wall of the self-made non-magnetic stainless steel crucible evenly with ZnO and talcum powder to white, and preheat the slag removal spoon, stirring spoon, and mold to 210°C; then when the furnace temperature rises to 430°C, put 500g magnesium block Put it into the crucible and continue to raise the temperature to 715°C, keep it warm for 18 minutes to melt the magnesium block; remove the slag when the temperature drops to 710°C, and add 15.8g of Zn block; Add granular Mg-30wt.%Ca master alloy and 5.3gMg-30wt.%Zr master alloy at the same time,...

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Abstract

The invention discloses a magnesium alloy biological implant material and a preparation method thereof and belongs to the field of biomaterials. The magnesium alloy biological implant material is a magnesium alloy composed of Mg, Zn, Ca and Zr. The magnesium alloy biological implant material comprises the following chemical components in percentages by mass: 2.0-6.0% of Zn, 0.3-0.9% of Ca, 0.3-0.6% of Zr and the balance of Mg. The preparation method comprises the following steps of: manufacturing a cast ingot by means of a whole course gas shield resistance furnace smelting plus a rotating magnetic field and an ultrasonic external field compound treatment technology; and then performing homogenization treatment and thermal compressional deformation to obtain a second phase in dispersive distribution of uniform and fine Mg0.97Zn0.03 and Ca2Mg6Zn3 on a magnesium matrix so as to obtain the fully degradable biomedical magnesium alloy which is optimal in high toughness and corrosion resistant. The magnesium alloy biological implant material disclosed by the invention can be used in the medical fields of interventional therapy for cardiovascular diseases and endosteal implanting and the like.

Description

technical field [0001] The invention relates to a magnesium alloy biological implant material and a preparation method thereof, belonging to the field of magnesium alloy biological materials. Background technique [0002] In vivo biodegradable absorbent materials are a hotspot in the research of biomaterials. Biodegradable absorbing materials for clinical application are mainly polymers and certain ceramic materials, such as polylactic acid, calcium phosphate, etc., but the strength of polymer materials is low, and the plasticity and toughness of ceramic materials are poor. The advantages of metal materials such as stainless steel, titanium alloy and cobalt-chromium alloy for medical implants lie in their good mechanical properties and corrosion resistance, which can maintain the overall structural stability in the body for a long time. However, these metal materials cannot be degraded in the body after implantation, and remain permanently in the body as foreign bodies, whi...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C22C23/04C22C1/03C22F1/06C22B9/02A61L27/42A61L27/58A61L27/50A61L31/12A61L31/14
CPCA61L27/427A61L27/50A61L27/58A61L31/124A61L31/14A61L31/148A61L2430/02C22B9/026C22C1/03C22C23/04C22F1/06
Inventor 李慧刘燕萍许春香张金山杨文甫卜颖宏阎佩雯王陆
Owner TAIYUAN UNIV OF TECH
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