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Preparation method of aqueous-film-coated enterosoluble zinc oxide micro-pills

A technology of film coating and zinc oxide, which is applied to medical preparations containing no active ingredients, medical preparations containing active ingredients, and the digestive system. Cost, enhance bioavailability, avoid the effect of heat of solvation

Inactive Publication Date: 2017-12-15
合肥安生医药科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

This method greatly increases the cost of use due to the use of organic solvents such as ethanol, and has relatively high requirements for the protection of operators and the fire protection of workshops.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0018] Weigh 11Kg zinc oxide, 1.5Kg starch, 1.5Kg dextrin, 1.3Kg silicified microcrystalline cellulose, 200g crospovidone, add 1.6Kg purified water into the tank mixer, stir and mix to form a wet soft material, Then add the mixed soft material into the oscillating granulator, extrude it into irregular granular material with a 20-mesh aperture screen, then put the material into the centrifugal shot blasting machine and throw it round for 5 minutes, and put the shot blasted material in 80 Dry in an oven at ℃ for 3 hours to obtain a semi-finished product. After sieving, add 15Kg of 20-60 mesh semi-finished products into the fluidized bed, spray into the enteric coating solution, and the composition of the coating solution: 9Kg hydroxypropyl methylcellulose phthalate aqueous dispersion, 500g talcum powder, 900g PEG6000, 5Kg of purified water, after the coating solution is sprayed, continue to dry at a low temperature of 50°C for 30 minutes and discharge.

Embodiment 2

[0020] Weigh 11Kg of zinc oxide, 2.5Kg of starch, 0.5Kg of dextrin, 1.3Kg of microcrystalline cellulose, and 200g of croscarmellose sodium, and add 1Kg of syrup with a concentration of 20% in a tank mixer, stirring and mixing Wet and soft materials are formed, and then the mixed soft materials are added to the oscillating granulator, squeezed into irregular granular materials with a 20-mesh aperture screen, and then the materials are put into a centrifugal shot blasting machine and rounded for 5 minutes. The materials were dried in an oven at 80°C for 3 hours to obtain semi-finished products. After sieving, add 14Kg of 20-60 mesh semi-finished products into the fluidized bed, spray into the enteric coating solution, and the composition of the coating solution: 9Kg hydroxypropyl methylcellulose phthalate aqueous dispersion, 500g talcum powder, 90g lemon Acetate triethyl ester, 6Kg purified water, after the coating solution is sprayed, continue to dry at 50°C for 30 minutes and ...

Embodiment 3

[0022] Weigh 11Kg zinc oxide, 0.5Kg lactose, 1.5Kg starch, 1.3Kg microcrystalline cellulose, 200g talcum powder in a tank mixer, add 1Kg concentration of 10% starch slurry, stir and mix to form a wet soft material, and then Put the mixed soft material into the oscillating granulator, extrude it into irregular granular materials with a 20-mesh sieve, then put the materials into the centrifugal shot blasting machine and round them for 5 minutes, and put the shot blasted materials in an oven at 80°C Dry for 3 hours to get semi-finished products. After sieving, add 14.5Kg of 40-60 mesh semi-finished products into the fluidized bed, spray into the enteric coating solution, and the composition of the coating solution: 9Kg enteric latex, 500g magnesium stearate, 90g hydroxypropyl methylcellulose, 500g PEG6000, 6Kg purified water, after the coating solution is sprayed, continue to dry at 50°C for 30min and discharge.

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Abstract

The invention discloses a preparation method of aqueous-film-coated enterosoluble zinc oxide micro-pills. The aqueous-film-coated enterosoluble zinc oxide micro-pills are composed of the following ingredients: in per 100% by mass, 40-85% of zinc oxide, and 15-60% of auxiliary materials; (b), enterosoluble film coating layers of which the weight accounts for 5-30%, preferably 10-20%, of the weight of the zinc oxide micro-pill cores; and (c), particle size of the final zinc oxide micro-pills is 10-100 meshes, preferably 40-60 meshes. The aqueous-film-coated enterosoluble zinc oxide micro-pills are non-soluble in the stomach but soluble in the intestinal tract; and solution rate of the zinc oxide micro-pills in the intestinal tract is adjustable from 30 minutes to 3 hours, and thus, the zinc oxide can be uniformly dispersed in the intestinal tract. The aqueous-film-coated enterosoluble zinc oxide micro-pills have characteristics of common enterosoluble zinc oxide, namely the effects of preventing diarrhea and low dosage; moreover, usage of organic solvents in preparation processes of the enterosoluble zinc oxide is also avoided so that the preparation method of the aqueous-film-coated enterosoluble zinc oxide micro-pills is environmentally friendly, free of potential safety hazard, and capable of greatly improving economic benefits.

Description

technical field [0001] The invention belongs to the field of feed additives, and in particular relates to a preparation method of water-based film-coated enteric-coated zinc oxide pellets. Background technique [0002] Zinc is an essential element for animals. It is a component of more than 40 metalloenzymes in the body, an activator of more than 200 enzymes, and participates in the processes of nucleic acid and protein synthesis, energy metabolism, redox, cellular immunity and humoral immunity. [0003] Announcement No. 1224 of the Ministry of Agriculture "Code for the Safe Use of Feed Additives" stipulates that the maximum content of zinc in piglet feed shall not exceed 2250mg / Kg, and this zinc must come from zinc oxide. This high-zinc diet can only For piglets in the first two weeks after weaning. Other feeds supplemented with zinc generally do not use zinc oxide. And the concentration shall not exceed 150mg / Kg. [0004] In Zhao Biqian's paper "Effect of enteric-coated...

Claims

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Application Information

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IPC IPC(8): A23K50/30A23K50/60A23K20/20A23K20/163A23K20/28A23K20/132A23K20/10A23K20/158A23K20/105A23K40/10A23K40/30A61K33/30A61K9/50A61K47/32A61K47/38A61P1/12A61P31/04
CPCA23K50/30A23K20/10A23K20/105A23K20/132A23K20/158A23K20/163A23K20/28A23K20/30A23K40/10A23K40/30A23K50/60A61K9/5026A61K9/5042A61K9/5047A61K33/30
Inventor 李凤和李效文边侠玲王莹莹闵磊磊
Owner 合肥安生医药科技有限公司
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