Preparation method of aqueous-film-coated enterosoluble zinc oxide micro-pills

Abstract

The invention discloses a preparation method of aqueous-film-coated enterosoluble zinc oxide micro-pills. The aqueous-film-coated enterosoluble zinc oxide micro-pills are composed of the following ingredients: in per 100% by mass, 40-85% of zinc oxide, and 15-60% of auxiliary materials; (b), enterosoluble film coating layers of which the weight accounts for 5-30%, preferably 10-20%, of the weight of the zinc oxide micro-pill cores; and (c), particle size of the final zinc oxide micro-pills is 10-100 meshes, preferably 40-60 meshes. The aqueous-film-coated enterosoluble zinc oxide micro-pills are non-soluble in the stomach but soluble in the intestinal tract; and solution rate of the zinc oxide micro-pills in the intestinal tract is adjustable from 30 minutes to 3 hours, and thus, the zinc oxide can be uniformly dispersed in the intestinal tract. The aqueous-film-coated enterosoluble zinc oxide micro-pills have characteristics of common enterosoluble zinc oxide, namely the effects of preventing diarrhea and low dosage; moreover, usage of organic solvents in preparation processes of the enterosoluble zinc oxide is also avoided so that the preparation method of the aqueous-film-coated enterosoluble zinc oxide micro-pills is environmentally friendly, free of potential safety hazard, and capable of greatly improving economic benefits.

Description

technical field

[0001] The invention belongs to the field of feed additives, and in particular relates to a preparation method of water-based film-coated enteric-coated zinc oxide pellets. Background technique

[0002] Zinc is an essential element for animals. It is a component of more than 40 metalloenzymes in the body, an activator of more than 200 enzymes, and participates in the processes of nucleic acid and protein synthesis, energy metabolism, redox, cellular immunity and humoral immunity.

[0003] Announcement No. 1224 of the Ministry of Agriculture "Code for the Safe Use of Feed Additives" stipulates that the maximum content of zinc in piglet feed shall not exceed 2250mg / Kg, and this zinc must come from zinc oxide. This high-zinc diet can only For piglets in the first two weeks after weaning. Other feeds supplemented with zinc generally do not use zinc oxide. And the concentration shall not exceed 150mg / Kg.

[0004] In Zhao Biqian's paper "Effect of enteric-coated...