Medical degradable implantable metal material

Abstract

The present invention relates to the field of medical materials, and provides an implantable metal material capable of being degraded in vivo. The invention discloses a multi-element zinc alloy comprising Zn, Cu, Ti, Mg and the like, wherein the multi-element zinc alloy comprises, by mass, 0-4.5% of Cu, 0-1.5% of Ti, 0-1.5% of Mg, and the balance of Zn, and can further contain 0-2% of Mn, 0-3% of Ag and the like, wherein Mg, Cu and Mn are essential elements of human body, and Ti and Ag are non-toxic elements, such that the introduction of toxic alloying elements is avoided. According to the present invention, the multi-element zinc-based alloy is prepared by selecting the high-purity raw material or intermediate alloy, the high-performance billet is obtained through processing, and the obtained product has advantages of good mechanical property, uniform corrosion and strong controllability, can meet the requirements of medical devices on safety and mechanical property, can be used in vascular stents, lumen stents, orthopedic implants, surgical suture devices and other devices, and is preferentially used for preparing degradable stents for the interventional therapy of coronary heart diseases and the temporary supporting of body lumens stenosis.

Description

technical field [0001] The invention relates to the field of biomaterials, which is an implantable metal material degradable in a living body. Background technique [0002] Nowadays, with the rapid development of life science and material science, patients tend to hope that the medical materials implanted in the body will only play a short-term replacement role, and will gradually degrade and be absorbed by the body along with the healing of wounded tissues or organs, to maximize Reduce the long-term impact of implant materials on the human body. However, biodegradable materials are easy to decompose in the body, and the degradation products participate in metabolism and are finally excreted from the body. They have no toxic side effects on the body, and meet the requirements of implants that only play a temporary replacement role, so they are increasingly valued by people. In recent years, magnesium alloys and iron alloys, as a new generation of revolutionary metal medical...

AI Technical Summary

Problems solved by technology

However, zinc-based alloys are rarely reported as degradable metal materials. After searching the literature of the prior art, D Vojtěch et al. reported the mechanical properties and corrosion properties of Zn-Mg alloys, and discussed its application in orthopedic implants. Feasibility of application (Acta biomaterialia,2011,7(9):3515-3522); PK Bowen et al. reported the implantation experiment of pure zinc in the abdominal aorta of mice, revealing its corrosion characteristics in vivo, and discussed the role of pure Zn as Feasibility of Metal Materials for Stents (Advanced Materials,2013,25(18):2577-2582)

However, the Zn-based alloy obtained by alloying mentioned in the above-mentioned documents has poor plasticity, and its elongation is about 1.5%, while the strength of pure zinc is not high, and its tensile strength is about 30MPa, which is seriously limited. its wide application

Recently, researchers have improved the performance of medical zinc-based alloy materials, such as the recently reported medical Zn-based alloy prepared by Kubásek J (Materials Science and Engineering: C, 2016, 58:24-35), Zn- 1Mg-based alloys (Journal of Biomedical Materials Research Part B: Applied Biomaterials, 2015, 103(8): 1632-1640) and Zn alloy materials prepared by Li HF (Scientific reports, 2015, 5, doi: 10.1038 / srep10719), etc., Although the mechanical properties have improved, it is still unsatisfactory in general

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