Citrate sugar alcohol solution for atomizing inhalation

Abstract

The invention provides an aqueous solution preparation of atomizing inhalation citrate and sugar alcohol for phlegm resolving. Specifically, the sugar alcohol is selected from any one of mannitol, sorbitol, inositol, galactitol, xylitol, arabinose and erythritol. The aqueous solution preparation provided by the invention greatly reduces dry throat and sore throat adverse reactions caused by citrate, and also improves the drug administration concentration of citrate at the same time.

Description

technical field [0001] The invention belongs to the field of pharmacy, in particular, the invention relates to an aqueous solution for nebulized inhalation containing citrate and sugar alcohol. Background technique [0002] Nebulization inhalation treatment is to disperse medicine and water into mist particles or particles suspended in the gas through the inhalation device, and deposit them in the respiratory tract and (or) lungs through inhalation, so as to achieve the effect of local treatment of the respiratory tract. Administration through nebulization inhalation can relieve bronchospasm, dilute sputum, and prevent respiratory tract infection. In many respiratory diseases, such as chronic obstructive pulmonary disease (COPD) in adults, bronchial asthma in children, acute laryngitis, allergic cough and other diseases, aerosol inhalation can be used for treatment. The biggest advantage of aerosol inhalation therapy is that the drug can directly reach the airway or lungs. ...

AI Technical Summary

Problems solved by technology

For the existing aerosol inhalation administration, most of them are converted from injections, and the problems of taste discomfort and oropharyngeal discomfort caused by the physical and chemical characteristics of the drug are rarely considered, and these two problems will cause problems during the medication process. The patient's compliance becomes poor, and after the patient's compliance becomes poor, it will be difficult to cooperate with the atomization unconsciously. For example, a very real problem is that although the patient has the atomization inhalation in his mouth, he will consciously or unconsciously Carry out a very slight inhalation or inhale air through the nose, and the exhaled water vapor enters the atomization cup again, resulting in the atomization inhalation that should have been completed in about 15 minutes, but the atomization still cannot be completed after 45 minutes, the atomization cup There is always a large amount of solution in the atomization cup, and such a process will lead to the waste of medicine and cannot reasonably enter the respiratory tract, causing insufficient dosage, and the medicine will be decomposed in the atomization cup for too long, and the temperature will increase, which will cause the medicine to decompose and cause unnecessary side effects.

[0004] In the process of developing potassium sodium citrate for atomized inhalation, in order to solve the problem of dry throat and stinging caused by potassium sodium citrate, we tried a variety of drugs and excipients, and finally found some sugar substances

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