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Preparation method of glucosamine potassium salt

A technology of glucosamine hydrochloride and glucosamine, which is applied in the field of preparation of glucosamine potassium salt, can solve the problems of glucosamine instability, product quality decline, cumbersome preparation process, etc., achieve good product quality, improve uniformity, and process Simple and reasonable effect

Inactive Publication Date: 2018-03-23
YANGZHOU RIXING BIO TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] Aiming at the deficiencies of the prior art, the present invention provides a preparation method of glucosamine potassium salt, which has the advantages of simple and reasonable process, good product quality and high purity, and solves the cumbersome traditional preparation process, and the free glucosamine is very unstable. It is very easy to produce decomposed impurities. After forming salt, it needs to increase the temperature to concentrate and remove water, which will cause the color of the finished product to become darker, resulting in a decline in product quality, and the product is highly water-absorbent, and the content is easy to decrease, which cannot achieve the desired drug effect.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0023] A potassium salt of glucosamine, comprising the following raw materials: glucosamine hydrochloride, potassium-containing alkaline substance, sulfuric acid, methanol, ethanol, propanol, isopropanol, n-butanol, tert-butanol, acetone, dioxane , dimethyl sulfoxide, and the balance is distilled water.

[0024] A preparation method of glucosamine potassium salt, comprising the following steps:

[0025] 1) Mixing: Mix methanol, ethanol, propanol, isopropanol, n-butanol, tert-butanol, acetone, dioxane, dimethyl sulfoxide and distilled water in a sealed container for later use.

[0026] 2) Dissolving: Take the mixed solvent reserved in step 1) for use as a backup, add glucosamine hydrochloride to dissolve in the solvent, stir until completely dissolved, collect the solution, and set aside.

[0027] 3) Add alkali: take the solution obtained in step 2), add a potassium-containing alkaline substance under the protection of one or more protective gases in nitrogen, carbon dioxide a...

Embodiment 2

[0031] A potassium salt of glucosamine, comprising the following raw materials: glucosamine hydrochloride, potassium-containing alkaline substance, sulfuric acid, methanol, ethanol, propanol, isopropanol, n-butanol, tert-butanol, acetone, dioxane , dimethyl sulfoxide, and the balance is distilled water.

[0032] A preparation method of glucosamine potassium salt, comprising the following steps:

[0033] 1) Mixing: Mix methanol, ethanol, propanol, isopropanol, n-butanol, tert-butanol, acetone, dioxane, dimethyl sulfoxide and distilled water in a sealed container for later use.

[0034] 2) Dissolving: Take the mixed solvent reserved in step 1) for use as a backup, add glucosamine hydrochloride to dissolve in the solvent, stir until completely dissolved, collect the solution, and set aside.

[0035] 3) Add alkali: take the solution obtained in step 2), add a potassium-containing alkaline substance under the protection of one or more protective gases in nitrogen, carbon dioxide a...

Embodiment 3

[0039] A potassium salt of glucosamine, comprising the following raw materials: glucosamine hydrochloride, potassium-containing alkaline substance, sulfuric acid, methanol, ethanol, propanol, isopropanol, n-butanol, tert-butanol, acetone, dioxane , dimethyl sulfoxide, and the balance is distilled water.

[0040] A preparation method of glucosamine potassium salt, comprising the following steps:

[0041] 1) Mixing: Mix methanol, ethanol, propanol, isopropanol, n-butanol, tert-butanol, acetone, dioxane, dimethyl sulfoxide and distilled water in a sealed container for later use.

[0042] 2) Dissolving: Take the mixed solvent reserved in step 1) for use as a backup, add glucosamine hydrochloride to dissolve in the solvent, stir until completely dissolved, collect the solution, and set aside.

[0043] 3) Add alkali: take the solution obtained in step 2), add potassium-containing alkaline substances under the protection of one or more protective gases in nitrogen, carbon dioxide an...

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Abstract

The invention relates to the technical field of medicine preparations, and discloses glucosamine potassium salt. The glucosamine potassium salt is characterized by being prepared from the following raw materials: glucosamine hydrochloride, a potassium-containing alkaline substance, sulfuric acid, methanol, ethanol, propyl alcohol, isopropanol, n-butyl alcohol, tertiary butanol, acetone, dioxane, dimethyl sulfoxide and the balance of distilled water; and the potassium-containing alkaline substance comprises potassium hydroxide, potassium carbonate, potassium bicarbonate, potassium methoxide, potassium ethoxide, potassium propoxide and potassium tert-butoxide. According to the preparation method of the glucosamine potassium salt, a solvent is prepared through mixing, then the glucosamine hydrochloride is dissolved, and the problem that the components are separated incompletely when the glucosamine potassium salt and auxiliary materials are mixed is solved, so that the uniformity of the glucosamine content of the raw materials is improved, the adhesion property and the flowability after the glucosamine potassium salt is mixed are improved, vacuum drying guarantees that a solution is not polluted by other substances in the air, a prepared product has high quality and high purity, and the product quality is improved.

Description

technical field [0001] The invention relates to the technical field of pharmaceutical preparations, in particular to a preparation method of glucosamine potassium salt. Background technique [0002] Glucosamine potassium salt is a drug for the treatment of arthritis. Arthritis has become the number one disabling disease in the world. With the aggravation of arthritis pain and the obstruction of activities, it will lead to temporary or permanent loss of working ability, bringing social and economic consequences. Because of its high activity and easy absorption, glucosamine potassium salt is the main matrix of articular cartilage and joint fluid, and is increasingly widely used in the treatment of arthritis. [0003] Glucosamine is an important substance that constitutes articular cartilage in the human body. It helps maintain the elasticity of connective tissue, and assists in the maintenance and repair of cartilage tendons and ligaments. It plays a vital role in the formatio...

Claims

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Application Information

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IPC IPC(8): C07H5/06C07H1/00
CPCC07H1/00C07H5/06
Inventor 丁振中柳志强曾哲灵史劲松张超冯小海龚劲松李恒方祥
Owner YANGZHOU RIXING BIO TECH