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Drug stent and preparation method thereof

A technology on a drug and a stent, applied in the field of drug stents and their preparation, can solve problems such as vascular restenosis, and achieve the effects of delaying endothelial repair, shortening the time of antithrombotic and platelet drugs, and preventing the incidence of vascular restenosis.

Active Publication Date: 2018-04-03
SHANGHAI MICROPORT MEDICAL (GROUP) CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0011] The invention provides a drug stent and a preparation method thereof, which are used to solve the problem of vascular restenosis after PCI

Method used

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  • Drug stent and preparation method thereof
  • Drug stent and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

experiment example 1

[0035] Experimental Example 1: Cell Experiment

[0036] A drug preparation:

[0037] (1) Amlexanox group:

[0038] a) Before the experiment, the drug stent loaded with amlexanox was placed in DMSO solution, and after it was completely dissolved, it was further diluted to form a drug concentration of 10 -2 mmol / ml solution.

[0039] b) add 10 -2 The drug solution of mmol / ml was diluted with dimethyl sulfoxide (DMSO) to a concentration of 10 -3 ,10 -4 ,10 -5 , 10 -6 ,10 -7 ,10 -8 ,10 -9 mmol / ml drug solution.

[0040] c) After dispensing the series of concentration drug solutions prepared above, store them temporarily at -20 degrees Celsius for later use.

[0041] d) When in use, dilute the stored DMSO for 10 -2 ~10 -9 After the amlexanox was taken out and returned to normal temperature, the drug solution of each concentration was diluted 1000 times with the corresponding complete cell culture medium to carry out the cell test, that is, the final use concentration w...

Embodiment 2

[0060] Example 2 carrier drug stent

[0061] Mix 50mg of amlexanox, 50mg of paclitaxel, 50mg of sirolimus, 50mg of aspirin and 500mg of PLGA in 100ml of acetone. After the solute is completely dissolved, spray the solution evenly on the L605 cobalt-chromium alloy metal stent by ultrasonic atomization On the surface of the body, the total drug loading of the four drugs reaches 130μg / cm 2 . The drug stent is prepared after the solvent is completely evaporated at room temperature.

Embodiment 3

[0062] Example 3 Carrier-free drug stent

[0063] Fine lines are formed on the surface of the stainless steel stent body through friction treatment, and the micronized amlexanox, paclitaxel, sirolimus, and aspirin are placed in a high-pressure airtight place with the stent body at a weight ratio of 2:1:1:1. In the equipment, turn on the equipment, so that the drug particles are embedded in the fine lines of the stent body, and the total drug loading amount reaches 160μg / cm 2 , the average particle diameter of the drug particles is not more than 1 micron, and the drug stent is obtained.

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Abstract

The invention belongs to the field of medical apparatuses, and in particular relates to a drug stent and a preparation method thereof. The drug stent comprises a stent main body and a pharmaceutical composition distributed on the surface of the stent main body, wherein the pharmaceutical composition consists of amlexanox, taxol, sirolimus and aspirin. The preparation method comprises the followingsteps: firstly, preparing mixed powder or a mixed solution of the pharmaceutical composition; and then, loading the medicine (the prepared mixed powder or the mixed solution) onto the surface of thestent main body in a dripping, land-filling or coating mode. According to the invention, the composition of the amlexanox, the taxol, the sirolimus and the aspirin is high in activity of inhibiting smooth muscle cell proliferation; the drug stent with the composition, in comparison with currently common drug eluting stents, also has the characteristic of being low in endothelial cell proliferationinhibiting performance; therefore, the drug stent can be used for preventing a vascular restenosis occurrence rate in a PTCA postoperative treatment process; and meanwhile, endothelial repair cannotbe delayed.

Description

technical field [0001] The invention belongs to the field of medical devices, and in particular relates to a drug support and a preparation method thereof. Background technique [0002] Amlexanox (Amlexanox) common name: 2-amino-7-isopropyl-5-oxo-5H[1]phenylpyranyl-[2,3,-b]-pyridine-3-carbonic acid di Toluic acid, also known as CHX3673. English chemical name: 2-amimo-7-isopropyl-5-oxo-5H-[1]benzopyrano-[2,3,-b]pyridine-3-carboxylic acid. Amlexanox is an allergic reaction mediator blocker, which stabilizes the cell membrane of mast cells and inhibits their degranulation, thereby preventing the release of allergic reaction mediators and exerting an anti-allergic effect. It was first launched in Japan in 1987 for the treatment of allergic bronchial asthma. Later applied to allergic rhinitis. In 1996, Amlexanox was approved by the US Food and Drug Administration (FDA) for the treatment of oral ulcers. [0003] Amlexanol is the only prescription drug approved by the US FDA f...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L31/16
CPCA61L31/16A61L2300/21A61L2300/216A61L2300/416A61L2300/45
Inventor 陈陆李俊菲李妍
Owner SHANGHAI MICROPORT MEDICAL (GROUP) CO LTD
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