Artificial medicine carrying coaxial regenerated intravascular stent and compound process preparation method thereof

A vascular stent and drug-carrying technology, applied in blood vessels, stents, pharmaceutical formulations, etc., can solve the problems of reducing the infection rate of artificial blood vessels, shortening the preparation time of stents, etc., so as to improve mechanical and biological properties, reduce infection risks, and increase tissue phase. capacitive effect

Active Publication Date: 2018-04-13
SHANGHAI UNIV
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0005] In order to solve the problems of the prior art, the object of the present invention is to overcome the deficiencies in the prior art, and provide an artificial drug-loaded coaxial regenerative vascular stent and its composite process preparation method, because the multi-process composite method is used to prepare the vascular stent , which overcomes the limitation of a single process and shortens the preparation time of the scaffold. The first layer and the second layer are tightly combined by capi

Method used

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  • Artificial medicine carrying coaxial regenerated intravascular stent and compound process preparation method thereof
  • Artificial medicine carrying coaxial regenerated intravascular stent and compound process preparation method thereof
  • Artificial medicine carrying coaxial regenerated intravascular stent and compound process preparation method thereof

Examples

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Embodiment 1

[0037] In this example, see Figure 1~3 , a method for preparing a drug-loaded coaxial regenerative vascular stent by a composite process, comprising the steps of:

[0038] a. PVA is dissolved in deionized water, heated in a water bath on a magnetic stirrer, and stirred until the PVA is completely dissolved, and the obtained mass percent concentration is 5wt.% PVA solution 35g;

[0039] b. Dissolve 20 mg of deferoxamine DFO in 10 g of the PVA solution prepared in step a to prepare the DFO inner layer coaxial electrospinning core layer solution;

[0040] c. Use a mixture of N,N-dimethylformamide DMF and dichloromethane DCM with a volume ratio of 1:1 as a solvent, dissolve 2g polycaprolactone PCL in 20ml of the above solvent, and prepare a PCL coaxial electrode Spin shell layer solution, divide into two equally again;

[0041] d. Sodium alginate SA is dissolved in deionized water to prepare 10 g of SA solution with a mass fraction of 3wt.%, and then the PVA solution and SA solut...

Embodiment 2

[0049] This embodiment is basically the same as Embodiment 1, especially in that:

[0050] In this embodiment, a method for preparing a drug-loaded coaxial regenerated vascular stent by a composite process includes the following steps:

[0051] a. PVA is dissolved in deionized water, heated in a water bath on a magnetic stirrer, and stirred until the PVA is completely dissolved, and the obtained mass percent concentration is 3wt.% PVA solution 35g;

[0052] b. Dissolve 20mg of deferoxamine DFO in the PVA solution prepared in the step a, and prepare a DFO inner layer coaxial electrospinning core layer solution with a mass percentage of 50wt.%.

[0053] c. Use a mixture of N,N-dimethylformamide DMF and dichloromethane DCM with a volume ratio of 1:1 as a solvent, dissolve 0.2g polycaprolactone PCL in 20ml of the above solvent, and prepare a PCL coaxial The electrospinning shell solution was divided into two equally;

[0054] d. Sodium alginate SA is dissolved in deionized water...

Embodiment 3

[0062] This embodiment is basically the same as the previous embodiment, and the special features are:

[0063] In this embodiment, a method for preparing a drug-loaded coaxial regenerated vascular stent by a composite process includes the following steps:

[0064] a. PVA is dissolved in deionized water, heated in a water bath on a magnetic stirrer, and stirred until the PVA is completely dissolved, and the obtained mass percent concentration is 8wt.% PVA solution 35g;

[0065] b. Dissolve 20mg deferoxamine DFO in the PVA solution prepared in the step a, and prepare a DFO inner layer coaxial electrospinning core layer solution with a mass percentage of 80wt.%.

[0066] c. Use a mixture of N,N-dimethylformamide DMF and dichloromethane DCM with a volume ratio of 1:1 as a solvent, dissolve 2g polycaprolactone PCL in 20ml of the above solvent, and prepare a PCL coaxial electrode Spin shell layer solution, divide into two equally again;

[0067] d. Sodium alginate SA is dissolved...

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Abstract

The invention discloses an artificial medicine carrying coaxial regenerated intravascular stent and a compound process preparation method thereof. The intravascular stent is provided with a three-layer structure which is prepared through different process methods, an inner-layer material adopts a deferoxamine DFO+PVA core layer solution and a PCL shell layer solution, and a coaxial electrospinning forming process is adopted; a middle-layer material adopts a PVA+SA mixed solution, a dipping method forming process is adopted, and calcium chloride is adopted for cross linking after outer layer electrospinning is carried out; an outer-layer material adopts a gentamicin GS+PVA core layer solution and a PCL shell layer solution, and the coaxial electrospinning forming process is adopted. The three-layer medicine carrying intravascular stent is prepared through the two processes by compounding different materials, the three-layer structure of a natural blood vessel is simulated well, the time needed by in-vitro culture and transplantation is shortened, the success rate is increased, and the intravascular stent has wide prospects in clinical application.

Description

technical field [0001] The invention relates to an artificial blood vessel and a preparation method thereof, in particular to a regenerated blood vessel support and a composite process preparation method thereof, which are applied in the technical field of biomanufacturing. Background technique [0002] Cardiovascular disease, especially coronary heart disease caused by arteriosclerosis, has become one of the main causes of human death, and one of the main means of treatment is vascular transplantation. Due to the limited sources of autologous blood vessels, a large number of artificial blood vessels are required for clinical use. [0003] With the increase in the demand for artificial blood vessels, artificial blood vessels prepared by various processes have been produced one after another. Among them, artificial blood vessels prepared by bioprinting technology are increasingly used in blood vessel preparation due to their outstanding performance in function and efficiency....

Claims

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Application Information

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IPC IPC(8): A61F2/07A61L27/16A61L27/18A61L27/20A61L27/50A61L27/52A61L27/54A61L27/56A61L27/58
CPCA61F2/07A61F2240/001A61L27/16A61L27/18A61L27/20A61L27/507A61L27/52A61L27/54A61L27/56A61L27/58A61L2300/204A61L2300/232A61L2300/406A61L2300/604A61L2400/12A61L2430/22C08L29/04C08L67/04C08L5/04
Inventor 胡庆夕吴闯张海光谢明亮刘亦江晨余红臣
Owner SHANGHAI UNIV
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