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Dialysis membrane for hemodialysis

A hemodialysis and dialysis membrane technology, applied in the field of hemodialysis dialysis membranes, can solve problems such as protein adsorption and platelet aggregation, achieve high biocompatibility, improve safety, and reduce the incidence of blood infection.

Inactive Publication Date: 2018-04-20
成都测迪森生物科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, polylactic acid also has its own defects, such as partial hydrophobicity, which leads to problems such as protein adsorption and platelet aggregation.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0025] This embodiment provides a chitosan quaternary ammonium salt-polylactic acid composite membrane and a preparation method thereof. The chitosan quaternary ammonium salt-polylactic acid composite membrane is a positively charged hollow fiber membrane, which is used as a dialysis membrane for hemodialysis It has a good application prospect. This chitosan quaternary ammonium salt-polylactic acid composite film is prepared through the following steps:

[0026] Step 1: Take 26g of chitosan quaternary ammonium salt, 107g of polylactic acid, and 29g of polyethylene glycol, and dissolve them in 1L of dimethylacetamide at 50°C to obtain a polylactic acid mixture; add formazan to the polylactic acid mixture 0.4g of glycidyl methacrylate, add 0.001g of azobisisobutyronitrile after 20min of nitrogen gas, raise the temperature to 50°C and carry out free radical polymerization reaction for 24h under the protection of nitrogen to obtain chitosan mixed with glycidyl methacrylate Sugar ...

Embodiment 2

[0030] This embodiment provides a chitosan quaternary ammonium salt-polylactic acid composite membrane and a preparation method thereof. The chitosan quaternary ammonium salt-polylactic acid composite membrane is a positively charged hollow fiber membrane, which is used as a dialysis membrane for hemodialysis It has a good application prospect. This chitosan quaternary ammonium salt-polylactic acid composite film is prepared through the following steps:

[0031] Step 1: Take 28g of chitosan quaternary ammonium salt, 109g of polylactic acid, and 32g of polyethylene glycol, and dissolve them in 1L of dimethyl sulfoxide at 50°C to obtain a polylactic acid mixture; add methyl alcohol to the polylactic acid mixture Glycidyl acrylate 0.6g, add 0.001g of azobisisobutyronitrile after 30min of nitrogen gas, raise the temperature to 60°C and carry out free radical polymerization reaction under nitrogen protection for 20h to obtain chitosan mixed with glycidyl methacrylate Quaternary am...

Embodiment 3

[0035]This embodiment provides a chitosan quaternary ammonium salt-polylactic acid composite membrane and a preparation method thereof. The chitosan quaternary ammonium salt-polylactic acid composite membrane is a positively charged hollow fiber membrane, which is used as a dialysis membrane for hemodialysis It has a good application prospect. This chitosan quaternary ammonium salt-polylactic acid composite film is prepared through the following steps:

[0036] Step 1: Take 33g of chitosan quaternary ammonium salt, 111g of polylactic acid, and 34g of polyethylene glycol, and dissolve them in 1L of chloroform at 50°C to obtain a polylactic acid mixture; add glycidyl methacrylate to the polylactic acid mixture 0.7g of ester, 0.001g of azobisisobutyronitrile was added after 40min of nitrogen gas, the temperature was raised to 70°C, and free radical polymerization was carried out under the protection of nitrogen for 18h to obtain chitosan quaternary ammonium salt mixed with glycid...

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PUM

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Abstract

The invention discloses a dialysis membrane used for hemodialysis and relates to the field of medical equipment. The dialysis membrane that is used for hemodialysis of the present invention, its raw material comprises by mass fraction: Its raw material comprises by mass fraction: chitosan quaternary ammonium salt 26-33 parts, polylactic acid 107-111 parts, polylactic acid 29-34 parts of ethylene glycol, 0.5-0.8 parts of heparin, 0.10-0.14 parts of ethylenediamine, 0.4-0.7 parts of glycidyl methacrylate, 0.05-0.08 parts of N,N-dicyclohexylcarbodiimide, butyl Diimide 0.02-0.04 parts. The dialysis membrane of the present invention is made of modified polylactic acid composite material and has good biocompatibility; heparin is fixed on the dialysis membrane and has anticoagulant effect; the chitosan quaternary ammonium salt in the raw material makes the composite membrane positively charged, Form a positive charge barrier, effectively resist the bacteria in the dialysate from entering the blood, reduce the chance of infection, and improve the safety of clinical application.

Description

technical field [0001] The invention relates to the field of medical equipment, in particular to a dialysis membrane for hemodialysis. Background technique [0002] Hemodialysis is to use the principle that the solute flows from the side with high concentration to the side with low concentration, and introduce the two solutions of blood and dialysate into the dialyzer with hollow fiber semi-permeable membrane at the same time, so that the blood is located in the hollow fiber semi-permeable membrane. The dialysate is located on the other side of the hollow fiber semi-permeable membrane, so that the solutions on both sides of the membrane can remove medium and small molecule toxins in the human blood through diffusion and osmosis. At the same time, the electrolytes in the blood can also pass through Osmosis reaches balance, so as to achieve the purpose of blood purification. Hemodialysis is also a common method for the treatment of edematous diseases, acute and chronic renal ...

Claims

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Application Information

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IPC IPC(8): B01D71/08B01D71/48B01D67/00B01D69/08A61M1/16
CPCB01D71/08A61M1/1621A61M2205/02A61M2205/0205B01D67/0006B01D69/08B01D71/48
Inventor 郑浩
Owner 成都测迪森生物科技有限公司
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