The invention discloses a three-dimensional gear transverse / vertical inside-tightening direct-type casing pipe connection structure. The connection structure comprises a pipe body and a clamp. The clamp comprises a clamp strap and a fixing device for fixing the clamp strap. The fixing device comprises a worm and a housing, the clamp strap is arranged on the inner side of the pipe body, an open hole is formed in the position, in contact with the clamp strap, of the pipe body, the housing penetrates through the open hole in the pipe body to be fixed at one end of the clamp strap, the other end of the clamp strap penetrates into the pipe body or is exposed outside the pipe body by penetrating through the housing, the worm is arranged inside the housing and matched with the outer edge of the housing in a rotating mode, and a tooth groove of the clamp strap is meshed with external threads of the worm. Original point contact is changed to surface contact in the connection structure, the stress area is large, loosening does not easily occur, stability is good, fixing capacity is high, impact of external force can be resisted, concrete is prevented from entering the connection structure, construction can be carried out in the transverse and longitudinal directions, good practicability is achieved, the structure is simple, work efficiency is improved, and work cost is reduced.