A kind of method for ethylbenzene continuous oxidation separation coupling strengthening synthesis acetophenone and α-phenethyl alcohol

Abstract

The invention discloses a method for synthesizing acetophenone and alpha-phenethyl alcohol through continuous ethylbenzene oxidation, separation and coupling reinforcement. An ethylbenzene material containing water and metalloporphyrin is added to a reactor, wherein the reactor comprises a reaction tower and at least two constant-temperature settling towers, and a gas phase zone, an oxidation zoneand a gas outlet are arranged in the reaction tower; the oxidation zone and the constant-temperature settling towers of the reactor are filled with ethylbenzene, air is continuously introduced from the bottom of the oxidation zone to contact with ethylbenzene for a reaction, produced acetophenone and alpha-phenethyl alcohol products and water form a mixed phase to settle and enter one constant-temperature settling tower, ethylbenzene in the constant-temperature settling tower enters the oxidation zone of the reactor through external circulation, so that the reaction is performed continuously,when the mixed phase continuously settles until the constant-temperature settling tower is full of ethylbenzene, the reaction tower is switched to be communicated with another constant-temperature settling tower, and the process is alternately performed for continuous production. With the adoption of the method, the yield of acetophenone and alpha-phenethyl alcohol is high, the alcohol-ketone ratio is high, the method can be applied to continuous production, the production efficiency is greatly improved, and the production cost is reduced.

Description

technical field [0001] The invention relates to a method for preparing acetophenone and α-phenylethanol by oxidation of ethylbenzene, in particular, a method for preparing acetophenone and α-phenylethanol by catalyzing air oxidation of ethylbenzene with a biomimetic metalloporphyrin catalyst; In particular, it relates to a method for realizing the continuous oxidation, separation, coupling and enhanced synthesis of acetophenone and α-phenylethanol by using a reaction separation synchronous reactor, and belongs to the technical field of organic intermediate synthesis. Background technique [0002] Acetophenone and α-phenylethanol are common organic raw materials and intermediates. Acetophenone can be widely used in the preparation of drugs, resins, flavoring agents and tear gas, such as the preparation of sleeping pills, etc., the synthesis of mandelic acid, α-phenylindole, ibuprofen, etc., and also as cellulose ester and resin and other solvents and plasticizers in the prod...

AI Technical Summary

Problems solved by technology

The conversion rate of its ethylbenzene is increased to about 45%, but the selectivity of its α-phenylethanol is only about 10%, and it needs to adopt pure oxygen as an oxidant, and needs to use solvent and hydrogen transfer agent, which increases the product difficulty of separation

[0004] In summary, there are some substantial defects in the method of using metalloporphyrins to catalyze ethylbenzene to synthesize acetophenone and α-phenylethanol: 1) these reactions are batch reactions, which are difficult to industrialized large-scale production; To ensure the high conversion rate of ethylbenzene, the oxidation efficiency of ethylbenzene is usually improved by prolonging the reaction time or increasing the amount of oxidant and catalyst, but these conditions are not conducive to the formation of α-phenylethanol. However, only acetophenone can be obtained as the absolute main product; 3) the existing catalytic oxidation reaction usually requires the addition of solvents and catalytic promoters, which increases the cost and the difficulty of product separation

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