Fifteen-nuclear silver cluster taking tri((diphenylphosphine)methene)amine as ligand as well as synthetic method and antitumor application thereof

A synthesis method and cluster technology, applied in the field of medicine, can solve problems affecting ribosomal subunit protein expression, cell apoptosis, damage, etc., and achieve good medicinal value and strong anti-tumor activity

Inactive Publication Date: 2018-04-24
GUANGXI NORMAL UNIV
View PDF2 Cites 0 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, there is no clear conclusion about its anti-tumor mechanism. It can enter cells through different ways and generate reactive oxygen species (ROS), which can damage certain components of cells, such as DNA double strands. Destroy and affect the expression of ribosomal subunit proteins, resulting in apoptosis or death of cells
There are many studies on the effect

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Fifteen-nuclear silver cluster taking tri((diphenylphosphine)methene)amine as ligand as well as synthetic method and antitumor application thereof
  • Fifteen-nuclear silver cluster taking tri((diphenylphosphine)methene)amine as ligand as well as synthetic method and antitumor application thereof
  • Fifteen-nuclear silver cluster taking tri((diphenylphosphine)methene)amine as ligand as well as synthetic method and antitumor application thereof

Examples

Experimental program
Comparison scheme
Effect test

Example Embodiment

[0025] Example 1: Cluster compound [Ag 15 (N-triphos) 4 (Cl 4 ))(NO 3 ) 3 Synthesis

[0026] 1) Take 60mg (0.35mmol) of silver nitrate and dissolve it in 0.5mL of distilled water. After it is completely dissolved, add it to 2.5mL of methanol. When it is completely dissolved, add 30mg (0.05mmol) of NP 3 Put it on a magnetic stirrer and continue to stir for 30 min. After the reaction is complete, add 6 mL (0.53 mmol) of newly prepared sodium borohydride solution and react at room temperature for 20 hours;

[0027] 2) After the reaction is finished, centrifuge at 10000r / min for 2min in a high-speed centrifuge, discard the supernatant reaction solution, dissolve and extract with 7mL chloroform, and obtain black crystals after vapor diffusion of ether for one week.

[0028] The obtained black crystals were subjected to electrospray mass spectrometry and single crystal diffraction analysis. The specific electrospray mass spectrometry data are as follows:

[0029] (1) ESI-MS m / z :1402 [Ag ...

Example Embodiment

[0032] Example 2:

[0033] 1) Dissolve 60mg (0.35mmol) of silver nitrate in 3mL of ethanol. When it is completely dissolved, add 30mg (0.05mmol) of NP3 and place on a magnetic stirrer to continue stirring for 30 minutes. After the reaction is complete, add 6mL (0.53mmol) of newly prepared boron Sodium hydride solution, the solution quickly changes from colorless and transparent to black, and the reaction is stirred at room temperature for 20h;

[0034] 2) After the reaction is completed, centrifuge at 10000r / min for 2min in a high-speed centrifuge, discard the supernatant reaction solution, dissolve and extract with 1mL anhydrous methanol and 6mL chloroform, and diffusing ether in liquid phase for five days to obtain black crystals as the product. The obtained black crystal was analyzed by electrospray mass spectrometry and single crystal diffraction analysis, and it was determined to be the target cluster compound [Ag 15 (N-triphos) 4 (Cl 4 ))(NO 3 ) 3 .

Example Embodiment

[0035] Example 3:

[0036] The difference from Example 2 is that after the reaction is completed, the solvent is spin-dried with a rotary evaporator, and then 7 mL of chloroform is added to dissolve and extract, and the product can be obtained by diffusing the ether to obtain black crystals.

[0037] The obtained black crystal was analyzed by electrospray mass spectrometry and single crystal diffraction analysis, and it was determined to be the target cluster compound [Ag 15 (N-triphos) 4 (Cl 4 ))(NO 3 ) 3 .

[0038] In order to fully illustrate the use of the Ag15 cluster compound with tris((diphenylphosphino)methyl)amine as a ligand in pharmaceuticals, an antitumor activity experiment was carried out on it.

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

PUM

No PUM Login to view more

Abstract

The invention discloses a fifteen-nuclear silver cluster taking tri((diphenylphosphine)methene)amine as ligand as well as a synthetic method and antitumor application thereof. A chemical formula of the cluster is [[Ag15(N-triphos)4(Cl4)](NO3)3]; the cluster has a six-cap body heart cubic structure shown as a formula (I). A preparation method of the fifteen-nuclear silver cluster comprises the following steps: taking a compound shown as a formula (II) and silver nitrate, and dissolving the compound and the silver nitrate into a polar solvent; carrying out coordination reaction according to moleratio and reducing by using sodium borohydride to obtain a target product. An Ag15 cluster disclosed by the invention shows higher antitumor activity than that of a ligand NP3 and cis-platinum, has abetter potential medicinal value and can be prepared into an antitumor drug which is applied. The structures shown as the formula (I) and the formula (II) are shown in the description.

Description

technical field [0001] The invention relates to the field of medical technology, in particular to a pentanuclear silver cluster compound with tris((diphenylphosphine)methylene)amine as a ligand, its synthesis method, structure and anti-tumor application. Background technique [0002] Malignant tumors (commonly known as cancer) are one of the major diseases that endanger human health. The number of new cancer patients in the world is about 11 million every year, and the number of cancer deaths worldwide is about 7 million every year. The defense and treatment of malignant tumors have become the focus of the world's medical circles. The growth of tumors can be inhibited to varying degrees by radiotherapy, chemotherapy, and surgery. [0003] As a metal material with high biological safety and good stability, silver has attracted the attention of many researchers. In the reported literature, it is found that silver nanomaterials not only have significant antibacterial activit...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

Application Information

Patent Timeline
no application Login to view more
IPC IPC(8): C07F1/10A61P35/00
CPCC07B2200/13C07F1/005
Inventor 王修建彭艳倪青玲马梦霞
Owner GUANGXI NORMAL UNIV
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Try Eureka
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap