Drug for treating vasculogenesis mediated diseases and application
Patent Information
- Authority / Receiving Office
- CN · China
- Patent Type
- Applications(China)
- Current Assignee / Owner
- HARBIN MEDICAL UNIVERSITY
- Publication Date
- 2018-05-04
- Estimated Expiration
- Not applicable · inactive patent
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Abstract
Description
technical field
[0001] The invention belongs to the technical field of medicine, and in particular relates to a medicine for treating angiogenesis-mediated diseases and its application. Background technique
[0002] Blood vessels form an extensive network throughout the body, supplying oxygen and nutrients to every part of the body, and abnormal blood vessel growth and function are hallmarks of cancer as well as inflammatory diseases, leading to disease progression. Local lesions in vascular proliferation-related joint diseases rely on neovascularization to ensure a continuous supply of oxygen and nutrients to diseased and inflammatory cells. Under physiological conditions, the synovial lining of the joint is only composed of 1-2 layers of cells. In pathological conditions of arthropathy such as RA, inflammatory cytokines such as TNF-α and IL-1 promote a significant increase in the number of synoviocytes, usually reaching 4-10 layers. The fibroblast-like synoviocytes (FLS)...