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Material for generating calcium phytate in situ to seal dentin lumen and application thereof

A technology of dentinal tubules and dentin, used in dentistry, dental preparations, dental prostheses, etc., can solve the problems of uneven texture, poor adaptability of root canal walls, and inability to accurately control the length of gutta-percha tip entry.

Active Publication Date: 2018-05-08
BEIJING STOMATOLOGY HOSPITAL CAPITAL MEDICAL UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Traditional root canal filling materials are based on gutta-percha. After root canal filling, there is a gap between gutta-percha, sealant and the root canal wall, and the resulting micro-leakage is the main factor affecting the success of root canal treatment.
Cold gutta-percha lateral pressure filling technology has disadvantages such as uneven texture, poor adaptability to the root canal wall, and inability to tightly seal the entire root canal system. longitudinal fissure of root canal
At present, hot gutta-percha root canal filling technology still has the disadvantage of not being able to precisely control the length of gutta-percha tip entry like cold gutta-percha filling technology. In addition, due to the fluidity of hot gutta-percha, it is easy to cause gutta-percha and paste to exceed the apical foramen

Method used

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  • Material for generating calcium phytate in situ to seal dentin lumen and application thereof
  • Material for generating calcium phytate in situ to seal dentin lumen and application thereof
  • Material for generating calcium phytate in situ to seal dentin lumen and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0022] figure 2 The SEM figure of coating the reagent after the dentin acid etching of embodiment 1;

[0023] image 3 Dentin tubule section SEM figure after using the reagent in embodiment 1;

[0024] Figure 4 The dentin of embodiment 1 uses the SEM picture of described coating reagent 7 days

[0025] in Figure 1-4 The left and right pictures are pictures of different scales.

[0026] Figure 5 It is a light microscope (left) SEM (right) picture of the reagent embedded in the root canal of Example 2.

[0027] Specific experimental example

[0028] The present invention will be further described below in conjunction with the examples, but the present invention is not limited to the following examples.

[0029] Example 1: Occlusion of dentin tubules (tubules invisible to the naked eye)

[0030] Methods: 6 human premolars with intact crowns, no caries and cracks were selected from the Department of Oral and Maxillofacial Surgery of the School of Stomatology, Capital ...

Embodiment 2

[0037] Example 2: Apical foramen closure (canal visible to the naked eye)

[0038] Methods: 3 human premolars with intact crowns, no caries and cracks were selected from the Department of Oral and Maxillofacial Surgery of the School of Stomatology, Capital Medical University, freshly extracted for orthodontics (the patient gave informed consent, and the residual soft tissue on the root surface was removed with a curette after extraction, 4 ℃ physiological saline for storage, the time shall not exceed 4 weeks), and it shall be used as a test piece for future use.

[0039] Equipment: scanning electron microscope (Phenom proX, Phenom-World B.V., Netherlands), metallographic sample pre-grinding machine (YM-2A, Shanghai Metallographic Machinery Equipment Co., Ltd.), low-speed cutting machine (Isomet 4000Linear Precision Saw, Buehler, USA) ;

[0040] Materials: self-curing methyl methacrylate base resin (Shanghai Medical Instrument Co., Ltd. Dental Material Factory, referred to as se...

Embodiment 3

[0044] Dentin tubules blocked by adding ethanol to the reagent A in Example 3

[0045] Steps: Prepare reagent A: dissolve calcium phytate in deionized water, adjust the pH value between 3.5-4 with hydrochloric acid, and add 95% ethanol with a volume percentage of 0.5% at the same time; prepare reagent B: dissolve sodium hydroxide for deionization Prepare sodium hydroxide solution in water, adjust the pH value to 8-10, and add 95% ethanol with a volume percentage of 0.5% at the same time.

[0046] Before use, the dentin samples were etched with 37% phosphoric acid for 30 seconds, rinsed for 10 seconds, and then dried naturally to fully expose the dentin tubules for electron microscope observation. Apply reagent A on the surface of the dentin sample, let it dry naturally for 1 minute, then apply reagent B, let it dry naturally for 10 minutes, clean the tooth surface with deionized water, remove excess substances, etc., and observe with an electron microscope. Soak in artificial...

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Abstract

The invention provides a material for generating calcium phytate in situ to seal dentin lumen and application thereof and belongs to the technical field of dental materials. According to the materialprovided by the invention, a reagent A is an acidic solution of the calcium phytate. The reagent B is an alkaline solution of calcium hydroxide, potassium hydroxide, sodium hydroxide and the like. Thereagent A is brushed on the surface of exposed dentin or is put into a root canal; the reagent A enters a dentin tubule, a lateral branch root canal and the like, and also can reach an apical foramenalong the root canal; then the reagent B is brushed; the acidic solution of the calcium phytate in the dentin tubule, the lateral branch root canal or the apical foramen forms calcium phytate sediment along with the raising of the pH (Potential of Hydrogen) value and the dentin tubule, the lateral branch root canal or the apical foramen is blocked by the calcium phytate sediment. Hydrophilic components including ethanol, ethylene glycol and acetone can be added into the reagent A or the reagent B, so that the permeability is improved, and the dentin tubule, the lateral branch root canal and the apical foramen are further sealed. Elements including a silicon-containing compound and the like also can be added into the reagent B and are used for assisting calcium salt deposition in an oral cavity and tissues, furthermore, the dentin tubule, the lateral branch root canal and apical foramen are sealed.

Description

technical field [0001] The invention belongs to the technical field of oral tooth restoration, and relates to a material for generating calcium phytate precipitation in dentin tubules, lateral branch root canals or apical foramen to block dentin tubules, lateral branch root canals or apical foramen and its application method . Background technique [0002] Exposed dentin is associated with dentin hypersensitivity, pulpitis, and dentin bonding. With the continuous development of science and technology, new dentin sealing materials are constantly coming out. Although many technologies disclose the combined application of various materials for treating dentin hypersensitivity, improving cavity filling, etc., there is still a need to provide more effective materials and methods. [0003] Most of the methods for sealing dentin recently focus on the use of physical and chemical methods to seal open dentinal tubules through inorganic precipitation and remineralization, organic so...

Claims

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Application Information

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IPC IPC(8): A61K6/00A61K6/02
CPCA61K6/54A61K6/80
Inventor 张祖太李永梅丁宁
Owner BEIJING STOMATOLOGY HOSPITAL CAPITAL MEDICAL UNIV
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