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Composition, preparation and application of a magnetic liposome vesicle

A magnetic liposome and liposome technology, applied in transportation and packaging, chemical instruments and methods, dissolution, etc., can solve problems such as poor biocompatibility, poor emulsification performance, and instability of magnetic oleic acid vesicles , to achieve the effects of easy control, easy access to raw materials, and simple process

Active Publication Date: 2019-08-06
JIANGNAN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0009] The polymers in the above magnetic particle emulsifiers are all synthetic polymers, and their biocompatibility is far inferior to that of liposome materials such as oleic acid; and as mentioned earlier, the emulsification performance of liposomes such as oleic acid is not good And the magnetic oleic acid vesicles themselves are not stable

Method used

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  • Composition, preparation and application of a magnetic liposome vesicle
  • Composition, preparation and application of a magnetic liposome vesicle
  • Composition, preparation and application of a magnetic liposome vesicle

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0032] Embodiment one: Fe 3 o 4 Preparation of nanoparticles

[0033] 0.12mol of FeCl 3 ·6H 2 O and 0.06mol FeSO 4 ·7H 2 O was dissolved in a four-necked flask with 1000 mL of ultrapure water. Stir vigorously under a nitrogen atmosphere, quickly add 100mL of 25% concentrated ammonia water at 70°C, stir for 20min, take out the precipitated solid particles, cool to room temperature, and wash with water until neutral to obtain Fe 3 o 4 Nanoparticles. Disperse 1wt% nanoparticles in 10 times the volume of pH 10 buffer solution (borax-sodium hydroxide), drop it on the copper grid, absorb the excess solution with filter paper, and characterize it with TEM (200kV) after natural drying. See attached figure 1 (A)Fe 3 o 4 RT-TEM images.

Embodiment 2

[0034] Example 2: Preparation of magnetically conjugated linoleic acid vesicles CLA@Fe 3 o 4

[0035] In a water bath at 80°C, 1.2 g of Fe 3 o 4 Add the nanoparticles into a flask containing 100mL of ultrapure water, ultrasonically disperse the solution, adjust the pH of the solution to pH7 with 0.1mol / L hydrochloric acid aqueous solution, and slowly add 10mL of 17% sodium conjugated linoleate dropwise into the flask while stirring with nitrogen aqueous solution. After 1 hour, remove the flask from the water bath and cool it to room temperature, adjust the pH to about 5, place a magnet on the bottom of the flask to absorb the magnetic vesicles, remove the upper liquid by magnetic decantation, and wash the magnetic vesicles with ultrapure water for several times. The obtained magnetic vesicles were dried in a vacuum oven at 45°C to obtain magnetically conjugated linoleic acid particles (CLA@Fe 3 o 4 ).

[0036] Magnetic Conjugated Linoleic Acid Vesicular Particles CLA@Fe...

Embodiment 3

[0040] Example 3: Magnetic self-crosslinking conjugated linoleic acid vesicles SCLA@Fe 3 o 4 preparation of

[0041] The obtained 0.1g CLA@Fe in embodiment two 3 o 4 The vesicles were dispersed in 10mL of 0.015M phosphate buffer at pH 10, and added to a 25mL three-neck flask, and 7% APS aqueous solution of the monomer mass was added into the flask, and reacted in a water bath at 80°C for 7h under stirring with nitrogen to obtain SCLA@Fe 3 o 4 Vesicle solution. The absorbance A234 of the solution at 234 nm before and after self-crosslinking was measured with a UV-visible spectrophotometer, and the self-crosslinking was judged by comparing their changes. See attached Figure 5 (A)CLA@Fe 3 o 4 UV spectra before and after self-crosslinking, (B) SCLA@Fe 3 o 4 RT-TEM images.

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Abstract

The invention discloses the composition, preparation and application of a magnetic liposome vesicle, and belongs to the technical field of emulsifier preparation. The present invention adopts magnetic Fe 3 O 4 Nanoparticles induce self-assembly of conjugated linoleic acid (CLA) into magnetic vesicles, and then make CLA@Fe 3 O 4 Self-crosslinking of CLA molecules in bilayers yields stable SCLA@Fe 3 O 4 (Self-cross-linked conjugated linoleic acid) magnetic vesicles. The particle size of the prepared magnetic liposome vesicles does not exceed 25 nm, and can be used to prepare pH / magnetic dual-responsive Pickering emulsions, and the internal phase volume can be as high as 92%. The material used in the invention has good biocompatibility, simple process, easy-to-obtain raw materials, and easy control of particle size and shape.

Description

technical field [0001] The invention relates to the composition, preparation and application of magnetic liposome vesicles, in particular to the composition, preparation and application of magnetic liposome vesicles for stabilizing Pickering emulsions, and belongs to the technical field of emulsifier preparation. Background technique [0002] There are hidden dangers of accidental leakage and fire in the storage and transportation of oily liquid fuels and organic solvents. If an accident occurs, it will cause serious and irreversible damage to the ecosystem, the environment, and even human health. One of the ways to store and transport oil safely is to convert the oil into an oil-in-water emulsion, which is then broken at destination or before use. It is undoubtedly a good choice to mix oil and a small amount of water and emulsify with a particle emulsifier to prepare a stable O / W Pickering emulsion. Magnetic vesicles, that is, combinations of biocompatible magnetic nanopar...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): B01F17/00C10G73/40C09K23/00
CPCC10G73/40C09K23/017
Inventor 夏咏梅魏贝方云周卓愉
Owner JIANGNAN UNIV
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