Method for cladding UCNPs (upconversion nanoparticles) through low-temperature cyclodextrin carbonization

A nanoparticle and cyclodextrin technology, which is applied in the field of nano-fluorescent materials, can solve the problems of difficult control of the thickness of the coating carbonization layer, cumbersome operation process, and fluorescence quenching, so as to achieve improved biocompatibility, simple preparation process, and reduced biotoxic effects

Active Publication Date: 2018-05-25
DALIAN INST OF CHEM PHYSICS CHINESE ACAD OF SCI
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  • Summary
  • Abstract
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  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Recently, Li Fuyou's research group coated the upconversion material with a carbonized coating of glucose (Nat.Commun.7:10437). The coating needs to remove the oleic acid ligands on the surface. The operation process is cumbersome, and the thickness of the coated carbonized layer is not easy. Control, too thick carbon layer can easily cause fluorescence quenching of core upconversion materials

Method used

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  • Method for cladding UCNPs (upconversion nanoparticles) through low-temperature cyclodextrin carbonization
  • Method for cladding UCNPs (upconversion nanoparticles) through low-temperature cyclodextrin carbonization

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0025] 1. Prepare 50mg cyclodextrin and 40ml deionized water, and mix them to form the first mixture;

[0026] 2. Prepare 20 mg of up-conversion nanocrystals with a particle size of 100 nanometers, and disperse them in cyclohexane to form a second mixed solution;

[0027] 3. Mix the first and second mixed liquids and stir thoroughly for 2 hours to obtain the third mixed liquid;

[0028] 4. Heat the third mixed solution to 60°C, keep it for 80 minutes to evaporate and remove the cyclohexane, and cool to obtain a transparent aqueous solution;

[0029] 5. Add the aqueous solution into a polytetrafluoroethylene reactor, and react at 160 degrees Celsius for 16 hours under airtight conditions;

[0030] 6. The obtained product is centrifuged and washed several times, and dried to obtain a carbon-coated upconversion nanomaterial.

[0031] like Figure 1-2 Shown: It can be seen that there is a thin layer of carbon coated on the surface of up-conversion nanocrystals NaYF4:Yb,Er.

Embodiment 2～7

[0033] As in Example 1, the volume of the reaction solution, the temperature, and the time operating conditions are constant, and the quality of the cyclodextrin and the up-conversion quality are changed to test: the specific information is as follows:

[0034] serial number

Cyclodextrin quality

Upconversion Quality

Example 2

100mg

20mg

Example 3

200mg

20mg

Example 4

300mg

20mg

Example 5

400mg

20mg

Example 6

500mg

20mg

Example 7

600mg

20mg

[0035] like figure 1 and figure 2 The comparison shows: It can be seen that there is a thin layer of carbon coated on the surface of the up-conversion nanocrystal NaYF4:Yb, Er.

[0036] The prepared cyclodextrin carbon coating layer effectively reduces the biological toxicity, improves its biocompatibility, and can prevent the agglomeration of nanoparticles. The preparation process is simple, and it is beneficial to further mod...

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Abstract

The invention discloses a method for cladding UCNPs (upconversion nanoparticles) through low-temperature cyclodextrin carbonization. The method comprises steps as follows: firstly, aqueous dispersionis prepared from a cyclodextrin cladded oil-soluble upconversion nanomaterial; the dispersion is added to a polytetrafluoroethylene reaction kettle and subjected to a low-temperature hydrothermal reaction, and the UCNPs cladded with a thin cyclodextrin carbon layer are prepared. According to the method, the hydrophobic upconversion nanomaterial is successfully converted into a hydrophilic upconversion nanomaterial, and by means of the prepared cyclodextrin carbon cladding layer, biotoxicity is effectively reduced, and biocompatibility is improved; besides, the nanoparticles can be prevented from agglomeration, stability is improved, the preparation technology is simple, and further modification and application are facilitated.

Description

technical field [0001] The invention belongs to the technical field of nano fluorescent materials, and in particular relates to a method for carbonizing and coating upconversion nanoparticles with low-temperature cyclodextrin. Background technique [0002] Rare earth upconversion nanomaterials (upconversion nanoparticles UCNPs) refer to materials that can absorb long-wave radiation with low photon energy and emit short-wave radiation with high photon energy based on a two-photon or multi-photon mechanism when excited by light. Due to its unique optical and magnetic properties, it has attracted widespread attention in the fields of near-infrared lasers, solar cells, phosphors, biosensing analysis, and medical imaging. Up to now, the synthesis methods of upconversion nanomaterials mainly include thermal decomposition method, liquid solid solution (LSS) strategy and oleic acid route method. Most of the synthesized upconversion nanomaterials have hydrophobic oleic acid ligands ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C09K11/02C09K11/85
CPCC09K11/02C09K11/7773
Inventor 吴仁安赵兴云刘胜菊彭佳喜李鑫张红燕
Owner DALIAN INST OF CHEM PHYSICS CHINESE ACAD OF SCI
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