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Whitening composition containing coix seed fermentation liquor

A composition, coix seed technology, applied in the field of whitening composition, can solve the problems of high preparation cost, insufficient effect, single whitening effect, etc., achieve long-lasting effect, increase whitening effect, and promote the effect of synthesis

Active Publication Date: 2018-05-29
BIOPHARM RES & DEV CENT JINAN +2
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The production cost of such accelerators based on niacin and / or niacinamide is still relatively high
In addition, Japan Kao Co., Ltd. disclosed that the supernatant obtained by cultivating microorganisms in a medium containing bean dregs and sugars can be used as a ceramide and / or glucosylceramide production accelerator. The microorganisms include Rhodotorula and Pichia , Lactobacillus, Bacillus, Cryptococcus, Leuconostoc, Schizosaccharomyces, Candida, Saccharomyces, Yarrowia, Brettanomyces, Debaria, Geotrichum spp., Saccharomyces bühlerensis, and Hansenula spp., although these ceramide production accelerators are safe, they are not effective enough due to their single whitening effect

Method used

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  • Whitening composition containing coix seed fermentation liquor
  • Whitening composition containing coix seed fermentation liquor
  • Whitening composition containing coix seed fermentation liquor

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0048] The preparation of embodiment 1 coix seed fermented liquid

[0049] According to the preparation method recorded in the priority application 201711165203.6, the coix seed fermented liquid with high γ-aminobutyric acid content was prepared:

[0050] Step 1, weigh 15-25g of skimmed milk powder and add it to 100-250mL of warm boiled water, stir and disperse evenly, after the temperature cools below 40°C, add 0.5-1.0g of yogurt fermented bacteria powder (containing Streptococcus thermophilus, Bulgarian milk Bacillus, purchased from Beijing Chuanxiu Technology Co., Ltd.), stirred and dispersed evenly, cultured and fermented in a sealed manner until curdled milk was formed and the yogurt flavor was emitted, and the coix seed starter was made;

[0051] Step 2, wash the coix seed with water and dry it, then crush it through a 20-100 mesh sieve; weigh 150-200g coix seed powder and add it to 1.0L deionized water, stir to disperse, add liquefaction enzyme (purchased from Angel Yea...

Embodiment 2

[0053] The preparation of embodiment 2 whitening freeze-dried powder

[0054] In this example, a whitening freeze-dried powder containing coix seed fermented liquid, blue copper peptide and collagen was prepared.

[0055] The preparation method is as follows:

[0056] Take 0.03 g of blue copper peptide (purchased from Jitai Biotechnology Co., Ltd., production batch number 20170620), and then add 1.0 g of coix seed fermented liquid prepared in Example 1 and 0.015 g of macromolecular collagen (purchased from Guangzhou Xiangbo Biotechnology Co., Ltd., Molecular weight 100,000-300,000 Daltons), add water to make up to 3.0g, mix well, put in vials, freeze-dry at low temperature, and make whitening freeze-dried powder.

Embodiment 3

[0057] Example 3 Whitening ability test of whitening freeze-dried powder

[0058] Referring to the methods in the literature (Yan Hang, Tang Ting, Gui Hui, etc. The inhibitory effect of coicis extract on tyrosinase. Chinese patent medicine, 2013, 35(4): 696-699), through the detection of whitening freeze-dried powder (this Invention Example 2 preparation) on the inhibition of mushroom tyrosinase activity in vitro, according to the degree of solution fading and enzyme inhibition stoichiometry, quantitative analysis was carried out by spectrophotometry.

[0059] Method: Mix 0.5 mL of 30 mg / mL whitening lyophilized powder aqueous solution and 30 mg / mL arbutin aqueous solution (as a positive control) with 200 U mushroom tyrosinase, make up to 2.5 mL with PBS buffer, 37 Incubate at °C for 10 min, add 0.5 mL of L-tyrosine (purchased from Sigma), incubate at 37 °C for 15 min, and immediately detect the absorbance at 475 nm. In the experiment, the negative control was replaced with P...

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Abstract

The invention discloses a whitening composition containing a coix seed fermentation liquor, wherein the whitening composition comprises the following effective active components by the weight percentage: 5.0%-50.0% of the coix seed fermentation liquor, 0.1%-5.0% of copper glycyl-histidyl-lysine and 0.1%-6.0% of macromolecular collagen, wherein a preparation method of the coix seed fermentation liquor is described in the patent application having the application number of 201711165203.6 and applied by the inventor. The whitening composition can improve the enzyme activity of beta-glucocerebrosidase in skin, promotes the formation of ceramide of the skin and makes the skin bright and white. Under sustained release of the macromolecular collagen, the small-molecular active substances in the coix seed fermentation liquor and copper glycyl-histidyl-lysine have more lasting effect on the skin and have the effects of whitening, moisturizing and compacting the skin.

Description

[0001] This application requires the application number of 201711165203.6 (invention name is "a coix seed fermented liquid with high γ-aminobutyric acid content, its preparation method and its application", application date: November 20, 2017) Priority, the contents of which application is fully incorporated herein by reference. technical field [0002] The present invention relates to the field of cosmetics. Specifically, the present invention relates to a whitening composition comprising coix seed fermented liquid, blue copper peptide and macromolecular collagen as active ingredients. Background technique [0003] The main function of the skin is to protect the body from adverse factors in the external environment. The skin is divided into three layers, namely the epidermis, dermis and subcutaneous tissue. The most important barrier of the skin is located in the outermost layer of the skin, the stratum corneum. This unique combination of keratinocytes and lipids enables...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K8/9794A61K8/65A61K8/64A61Q19/02A61Q19/00
CPCA61K8/64A61K8/65A61K8/97A61K2800/78A61K2800/782A61K2800/85A61Q19/00A61Q19/02
Inventor 黄亚东项琪刘凌雪肖巧学唐连凤
Owner BIOPHARM RES & DEV CENT JINAN
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