Porous tantalum

A technology of porous tantalum and porous materials, applied in the field of porous tantalum for medical implant materials, which can solve the problems of poor human bone tissue, failure to be a bone repair material, and failure to achieve bone tissue regeneration, so as to be beneficial to bone tissue regeneration , good for adhesion and good for adsorption

Active Publication Date: 2018-05-29
CHONGQING RUNZE PHARM CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the medical implant materials obtained from this series of research results are still not effective in practical application.
At present, regardless of the porous tantalum medical implant materials reported in the literature or seen on the market, after implanted into the human body, the effect of human bone tissue growing into the implant material is not good, that is, the implant material cannot achieve bone tissue regeneration. , it cannot be a real bone repair material

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0024] The porous tantalum in this embodiment has secondary pores, in which the evenly distributed and interpenetrating first-level cavities (large cavities) have uniformly distributed and inter-connecting second-level cavities (small cavities) on the cavity wall , and the cavities at all levels are also connected to each other. Each level of porous tantalum is a continuous structure, the largest outer boundary of each level of porous tantalum is equivalent to the space boundary of the entire material body, and the pores of the same level of porous material at each level are evenly distributed in the material body. The preparation of porous tantalum with secondary pore structure adopts the following method: tantalum powder, pore-forming agent for preparing the second-level pore cavity, binder, and distilled water are prepared in proportion to make a slurry, ultrasonically dispersed, and the slurry is coated with polyester foam Uniform impregnation to form a green body and dry ...

Embodiment 2

[0035]The porous tantalum of this embodiment has secondary pores, wherein the uniformly distributed and interpenetrating first-level cavities have second-level cavities evenly distributed and interpenetrating on the wall of the cavity, and the cavities of each level are also mutually connected. through. Each level of porous tantalum is a continuous structure, the largest outer boundary of each level of porous tantalum is equivalent to the space boundary of the entire material body, and the pores of the same level of porous material at each level are evenly distributed in the material body. The pore diameter of the smallest pore (secondary pore) is 20µm-40µm, and the pore diameter of the upper pore (first-stage pore), which is one level larger than the smallest pore diameter, is 800µm-1200µm.

[0036] Its preparation method is similar to Example 1, wherein the pore size of the cavity is controlled by the particle size of the pore-forming agent and the pore size of the polyester...

Embodiment 3

[0039] The porous tantalum of this embodiment has secondary pores, wherein the uniformly distributed and interpenetrating first-level cavities have second-level cavities evenly distributed and interpenetrating on the wall of the cavity, and the cavities of each level are also mutually connected. through. Each level of porous tantalum is a continuous structure, the largest outer boundary of each level of porous tantalum is equivalent to the space boundary of the entire material body, and the pores of the same level of porous material at each level are evenly distributed in the material body. The pore diameter of the smallest pore (secondary pore) is 30µm-60µm, and the pore diameter of the upper pore (first-stage pore), which is one level larger than the smallest pore diameter, is 600µm-800µm.

[0040] Its preparation method is similar to Example 1, wherein the pore size of the cavity is controlled by the particle size of the pore-forming agent and the pore size of the polyester...

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Abstract

The invention discloses porous tantalum. The porous tantalum comprises a material body, and the porous tantalum belongs to a multi-level-hole material having hole cavities graded according to the holediameter size of the materials and cavity walls surrounding the hole cavities of all the levels, wherein the cavity wall of the previous-level large hole cavity is formed by a next-level cavity wallstructural material formed by a next-level small-hole-cavity structure with the hole diameter being smaller than that of the hole cavity of the previous level, the hole cavities of the porous materialof each level communicate with each other, the hole cavities of the porous materials of all the levels communicate with each other, teh water contact angle of the surface of the cavity wall of the hole cavity of the highest-level porous material of the porous tantalum is not greater than 48.5 degrees, so that the hydrophilia of the wall surface of the highest-level hole cavity is obviously improved, the biocompatibility is improved, the binding of the surface of the cavity wall with the blood and the tissue fluid is facilitated, the adsorption of protein is facilitated, the adhering, growth and spreading of osteoblasts are facilitated, and thus the regeneration of the bone tissue is facilitated.

Description

technical field [0001] The present invention relates to porous materials, in particular to a porous tantalum used in medical implant materials. Background technique [0002] Tantalum metal has been widely used in chemical industry, metallurgy, aerospace and other fields. Because tantalum has no reaction to body fluids, no irritation to body tissues, and is very compatible with human tissues, it is also an ideal material for making surgical implants. Such as cardiac pacemaker, skull defect repair, vascular clip, femoral stem prosthesis, wire, sheet or mesh for nerve repair, etc. However, dense tantalum metal has a large specificity and high elastic modulus, and the effect of direct implantation into the human body is not good. Therefore, people began to develop porous tantalum. The basic structure of porous tantalum metal has the characteristics of high overall volume porosity, high surface friction coefficient and low elastic modulus, making porous tantalum a promising new...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L27/56A61L27/04A61L27/50B22F3/11
CPCA61L27/047A61L27/50A61L27/56A61L2430/02B22F3/114
Inventor 叶雷
Owner CHONGQING RUNZE PHARM CO LTD
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