Microchannel reactor-based cyano hydrolysis reaction method

Abstract

The invention discloses a microchannel reactor-based cyano compound hydrolysis reaction method, and particularly, a compound comprising a cyano group in the molecule has the cyano hydrolysis reactionby using a microchannel reactor under the action of alkaline or acid-alkaline substances. By using the microchannel reactor in the process, the raw material is instantaneously evenly mixed and efficiently transfers heat; the most important danger of rushing of the material in the production process, caused by hydrolysis of the cyano compound through the alkali, is avoided; meanwhile, the equivalence ratio of the raw material in the reaction process is also reduced; the side reaction is reduced; the reaction time is shortened to dozens of minutes or even dozens of seconds. In a word, the process improves the operation safety of the reaction, the safe enlarged production of the cyano compound is realized, the time for the hydrolysis reaction of the cyano compound is shortened, the reaction selectivity and the reaction efficiency are improved, the energy consumption of the production is reduced, the use ratio of the raw material is increased, the production process is more environmentallyfriendly, the production cost is low, meanwhile, the used equipment occupies a small area, the production capacity of the equipment is high, and the production efficiency and the production capacityare greatly improved.

Description

technical field [0001] The invention relates to a method for carrying out cyano group hydrolysis reaction in a microchannel reactor, specifically, in the microchannel reactor, molecules containing cyano groups are hydrolyzed with lye or acid solution to generate compounds containing carboxyl groups, It belongs to the field of organic synthesis. Background technique [0002] Micro-reaction technology originated in the 1990s. In recent years, the advantages of micro-reactors have gradually become prominent, and they realized that micro-reactors are stronger than conventional mass and heat transfer capabilities, so micro-reactors were applied to the field of chemical synthesis; micro-reactions With the development of the device today, it is no longer simply pursuing the miniaturization of the reaction channel, but changing the fluid flow pattern through the reaction channel to form a micro-scale liquid flow, forming efficient and rapid mass and heat transfer. Utilizing these a...

AI Technical Summary

Problems solved by technology

This type of reaction can usually be hydrolyzed relatively completely under alkaline conditions, but cannot be completely reacted under acidic conditions. Under normal temperature and pressure conditions, the hydrolysis time of the cyano group is relatively long, and the hydrolysis efficiency is low. Often the reaction cannot be carried out completely, and amides and The mixture of carboxylic acids makes the purity of the final product not enough, so it is necessary to increase the temperature and pH of the hydrolysis, especially under the commonly used alkaline conditions, increasing the temperature will violently produce gas, it is difficult to control the reaction, and the risk is relatively large; and The conventional reaction is incomplete under acidic conditions, and the amount of acid needs to be increased. These excess acids and bases also need to be neutralized, resulting in unnecessary waste and environmental pollution

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