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Quasi-micelle superparamagnetic nano particles and preparation method thereof

A superparamagnetic and nanoparticle technology, which is applied in capsule delivery, microcapsules, pharmaceutical formulations, etc., can solve the problem of being easily affected by factors such as solution polarity, pH, and ion concentration, and it is difficult to form regular size and shape polymer gels. In order to avoid problems such as uneven molecular weight of bundles and block copolymers, it can achieve the effects of secondary assembly, uniform and adjustable particle size, and easy purification and collection.

Inactive Publication Date: 2018-06-22
XINXIANG MEDICAL UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

Polymer micelles and inorganic nanoparticles are compounded by hydrophilic / hydrophobic interactions, hydrogen bonds, electrostatic forces, etc., but these interactions are easily affected by factors such as solution polarity, pH, and ion concentration. Stability needs to be improved
In addition, due to the inhomogeneous molecular weight of block copolymers, it is difficult to form polymer micelles with regular size and shape.
Furthermore, the composite micelles of polymer micelles and inorganic nanoparticles need further modification in order to achieve multifunctionality, and it is difficult to reassemble

Method used

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  • Quasi-micelle superparamagnetic nano particles and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0032] Example 1: Preparation of hydrophobic-hydrophilic micellar superparamagnetic nanoparticles Fe 3 o 4 / PMMA / PAA

[0033] 1. Co-precipitation method to prepare superparamagnetic Fe 3 o 4 Nanoparticles

[0034] 397.62mg (2mmol) FeCl 2 4H 2 O, 946.05 mg (3.5 mmol) FeCl 3 ·6H 2 O was dissolved in an appropriate amount of water and injected sequentially into the anaerobic reaction system, and then deionized water was added to make the final volume 80 mL. Slowly raise the temperature to 80°C under mechanical stirring (800rpm), slowly dropwise add ammonia water (5mL, 4mmol / L) to the reaction system, keep warm for 1 hour after the dropwise addition, and then stop heating. After the reaction solvent was cooled to room temperature, the product was transferred to an Erlenmeyer flask, magnetically separated, and washed three times with deionized water to obtain superparamagnetic Fe 3 o 4 nanoparticles.

[0035] 2. Preparation of Chloromethylated Superparamagnetic Fe Nanopa...

Embodiment 2

[0042] Example 2: Preparation of hydrophilic-hydrophobic micellar superparamagnetic nanoparticles Fe 3 o 4 / PMMA / PAA

[0043] 1. Co-precipitation method to prepare superparamagnetic Fe 3 o 4 Nanoparticles

[0044] 397.62mg (2mmol) FeCl 2 4H 2 O, 946.05 mg (3.5 mmol) FeCl 3 ·6H 2 O was dissolved in an appropriate amount of water and injected sequentially into the anaerobic reaction system, and then deionized water was added to make the final volume 80 mL. Slowly raise the temperature to 80°C under mechanical stirring (800rpm), slowly dropwise add ammonia water (5mL, 4mmol / L) to the reaction system, keep warm for 1 hour after the dropwise addition, and then stop heating. After the reaction solvent was cooled to room temperature, the product was transferred to an Erlenmeyer flask, magnetically separated, and washed three times with deionized water to obtain superparamagnetic Fe 3 o 4 nanoparticles.

[0045] 2. Preparation of Chloromethylated Superparamagnetic Fe Nanopa...

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Abstract

The invention discloses quasi-micelle superparamagnetic nano particles and a preparation method thereof. The quasi-micelle superparamagnetic nano particle is prepared from a superparamagnetic nano particle core and an amphiphilic polymer brush shell; the amphiphilic polymer brush shell is a quasi-micelle formed by a hydrophobic-hydrophilic block copolymer. The quasi-micelle superparamagnetic nanoparticles disclosed by the invention have the advantages of uniform and controllable particle size, high stability in a solution, monodisperse distribution, etc.

Description

technical field [0001] The invention relates to a superparamagnetic nanoparticle and a preparation method thereof, in particular to a micelle-like superparamagnetic nanoparticle and a preparation method thereof. Background technique [0002] Polymeric micelles are molecularly ordered aggregates formed by self-assembly of block copolymers in aqueous solution, with a classic "core-shell" structure. Polymeric micelles are widely used as carrier materials due to their hydrophilic / hydrophobic properties, specific functional groups, abundant assembly forms, and good biocompatibility. In order to obtain functional materials such as light, electricity, and magnetism, the composite of functionalized polymer micelles and inorganic nanoparticles is used to prepare new materials. [0003] The composite methods of polymer micelles and inorganic nanoparticles mainly include: surface adsorption method, solution co-assembly method, layer-by-layer assembly method, etc., among which layer-by...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K41/00A61K9/50A61K47/58A61K49/18A61K49/08A61K49/12
CPCA61K9/5026A61K41/0052A61K49/085A61K49/12A61K49/1824
Inventor 解丽芹南文滨赵长虹王燕王永学朱留强高嵩钛
Owner XINXIANG MEDICAL UNIV
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