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Preparation and drying methods of pachymaran powder

A Poria polysaccharide and drying method technology, applied in the field of preparing and drying to obtain Poria polysaccharide powder, can solve the problems of difficult industrialized production, low spray drying efficiency, poor product quality, etc. The effect of reducing consumption and energy consumption

Active Publication Date: 2018-07-10
武汉回盛生物科技股份有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0014] Aiming at the deficiencies in the prior art, the present invention provides a preparation and drying method of Poria cocos powder, which solves the problem of large consumption of organic reagents and high energy consumption in the existing water reflux extraction ethanol precipitation method or ethanol reflux extraction method It solves the problem that the existing ultrasonic extraction and enzymatic extraction are not easy for industrial production
The invention adopts the method of drying under normal pressure and then drying under reduced pressure to obtain the extract of Poria cocos polysaccharide, which solves the problems of low efficiency of spray drying and poor product quality, etc. The process is simple and easy, and it is beneficial to industrial production

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0027] Embodiment 1 A preparation and drying method of Poria polysaccharide powder, the steps are as follows:

[0028] (1) Extraction steps: take the Poria cocos block, crush it through an 80-mesh sieve to obtain 500 g of Poria cocos powder, add 15 L of 1.5mol / L sodium hydroxide solution, add volume to Poria cocos powder mass ratio of 30 mL:1 g, stir for 60 min at 50 ° C, and stir The rotation speed is 100rpm; after stirring and extraction, centrifuge at 2400rpm to obtain the supernatant, add 6mol / L hydrochloric acid solution to the supernatant, adjust the pH value to 9.0, let stand for 90min, and centrifuge at 800rpm to obtain 3.15kg of precipitate;

[0029] (2) Desalination step: take 3.15 kg of the precipitate obtained in the extraction step (1), add 18.9 L of water, the mass ratio of the added volume to the precipitate obtained in the extraction step is 6 L:1 kg, stir at 60° C. for 20 min, and the stirring speed is 100 rpm. After stirring, let it stand for 20 minutes; cent...

Embodiment 2

[0033] Embodiment 2 A preparation and drying method of Poria polysaccharide powder, the steps are as follows:

[0034] (1) Extraction steps: Take the Poria cocos block, crush it through a 14-mesh sieve to obtain 1000 g of Poria cocos powder, add 10 L of 0.1mol / L sodium hydroxide solution, add volume to Poria cocos powder mass ratio of 10 mL:1 g, stir for 40 min at 25 ° C, and stir The rotation speed is 40rpm; after stirring and extraction, centrifuge at 800rpm to obtain the supernatant, add 10mol / L hydrochloric acid solution to the supernatant, adjust the pH value to 6.5, let it stand for 30min, and centrifuge at 2400rpm to obtain 5.95kg of precipitate;

[0035] (2) Desalting step: take 5.95 kg of the precipitate obtained in the extraction step (1), add 17.85 L of water, the mass ratio of the added volume to the precipitate obtained in the extraction step is 3 L:1 kg, stir at 25° C. for 40 min, and the stirring speed is 40 rpm. After stirring, let it stand for 60 minutes; cent...

Embodiment 3

[0039] Embodiment 3 A preparation and drying method of Poria cocos polysaccharide powder, the steps are as follows:

[0040] (1) Extraction steps: Take the Poria cocos block, crush it through a 60-mesh sieve to obtain 500 g of Poria cocos powder, add 1.0 mol / L sodium hydroxide solution 10 L, add volume to Poria cocos powder mass ratio of 20 mL:1 g, stir at 70 ° C for 20 min, stir The rotation speed is 80rpm; after the stirring and extraction, centrifuge at 1200rpm to obtain the supernatant, add 4mol / L hydrochloric acid solution to the supernatant, adjust the pH to 7.5, let stand for 60min, and centrifuge at 1200rpm to obtain 3.00kg of precipitate;

[0041] (2) Desalting step: extract 3.00 kg of the precipitate obtained in step (1), add 15.0 L of water, the mass ratio of its added volume to the precipitate obtained in the extraction step is 5 L:1 kg, stir at 40° C. for 30 min at a stirring speed of 80 rpm, and stir After standing still for 40min; centrifuge at 1200rpm to get th...

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Abstract

The invention belongs to the technical field of Chinese pharmaceutical manufacturing, and particularly discloses preparation and drying methods of pachymaran powder, for preparing and drying to obtainpachymaran powder by taking poria cocos as a raw material. The preparation method includes steps of extracting, desalination and drying. In the method, sodium hydroxide solution or sodium bicarbonatesolution is used for stirring extraction, and thus cost and energy consumption of organic reagents are reduced greatly, production cycle and cost are saved and environmental protection is facilitatedas compared with conventional water-reflux extraction ethanol precipitation method or ethanol reflux extraction method. The drying method refers to the method of preparing pachymaran powder by decompression drying after ambient drying, which solves the problems of low spray drying efficiency, poor product quality and the like due to the fact that pachymaran with poor water solubility is not easyto form a homogeneous system in water. The preparation and drying methods are simple, convenient to operate, and good for industrial production.

Description

technical field [0001] The invention belongs to the technical field of traditional Chinese medicine pharmacy, and in particular relates to a method for preparing and drying poria cocos as a raw material to obtain poria cocos powder. Background technique [0002] In recent years, in the animal husbandry, there are widespread outbreaks of infectious diseases after vaccination, and the gradual increase in the dosage of medicines does not achieve the desired therapeutic effect. This phenomenon is largely due to the adverse consequences of long-term drug abuse and irrational vaccination, which lead to the decline of the immune function of livestock and poultry. In animal production, how to improve the immunity of animals so as to reduce its morbidity and thus improve its economic benefits has become an issue of increasing concern to relevant experts and farmers. Practice has proved that taking effective measures to activate the immune system and enhance the body's disease resist...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/715A61K9/14A61P37/04C08B37/00
CPCA61K9/14A61K31/715A61K2236/331A61K2236/39A61K2236/51A61K2236/53C08B37/0003
Inventor 张卫元李硕张靖曾勇朱秀高
Owner 武汉回盛生物科技股份有限公司
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