Organic matter and preparation method and application thereof

Abstract

The invention provides organic matter having a structure as shown in formula I. The organic matter comprises a near infrared fluorophore part with a tumor targeting effect and an efficient photosensitizer part which are connected through bonding. The organic matter can accumulate at a tumor position in a targeted manner and accurately detect the tumor position through near infrared living imaging,and when the organic matter reaches the tumor position, the bonding position is reduced by high-level mercaptan molecules in tumor cells to release the photosensitizer, and active oxygen is releasedthrough laser radiation to kill the tumor cells. The provided organic matter has targeting, near infrared fluorescent imaging and photodynamic therapy effects. Experiment results show that the provided organic matter can performing targeting imaging and photodynamic therapy on tumor in mouse bodies and is multifunctional organic matter integrating tumor imaging, diagnosing and treating. The invention further provides a preparation method of the organic matter and application of the organic matter in the preparation of drugs for treating cancer.

Description

technical field [0001] The invention relates to the field of biomedical technology, in particular to an organic substance and its preparation method and application. Background technique [0002] Fluorescence spectroscopy is widely used in biological analysis and imaging because of its high sensitivity, good selectivity, intuitive and accurate information, and the ability to scientifically explain the structure, distribution, content, and physiological functions of complex samples. However, many organisms and tissues emit fluorescence under the excitation of visible light, which seriously interferes with the fluorescence detection and imaging of biological samples. The fluorescence wavelength range of phosphatase (NADPH) and bilirubin is 430-470nm, which greatly affects the sensitivity and accuracy of fluorescence analysis in the visible light region. The study found that the fluorescence detection in the near-infrared spectral region is more suitable for the imaging analys...

AI Technical Summary

Problems solved by technology

[0005] At present, people's expectations for cancer diagnosis and treatment are getting higher and higher, and current research is mostly focused on the development of multifunctional nano-drug systems. Defects limit its application in clinical diagnosis and treatment

For example, quantum dot therapy uses inorganic heavy metal materials, which are easy to accumulate in living organisms and difficult to degrade; nano-gold / silver particles have a great impact on normal cell activities and metabolism in vivo, and the particle size and shape are greatly affected by the environment. The magnitude reduces its application in the field of tumor diagnosis and treatment; the distribution of nano-carbon materials in the body is complex and difficult to degrade, and there is potential biotoxicity; And the stability after combining with the drug carrier has a great influence; the size of lipid / polymer nanoparticles is difficult to control, easy to be metabolically degraded in vivo and the tumor targeting effect is poor; the metabolic ability of mesoporous nanomaterials is poor, Moreover, the interaction mechanism between the loaded diagnostic and therapeutic drugs and mesoporous materials is difficult to analyze, and the impact on the diagnostic and therapeutic process has not yet been comprehensively and deeply studied.

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