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Calcium-phosphorus compound-magnesium composite coating for bone implanting and preparation method thereof

A composite coating, compound technology

Inactive Publication Date: 2018-07-20
HOSPITAL OF STOMATOLOGY CHINA MEDICAL UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] The purpose of the present invention is to solve the problems of osseointegration and infection of implant materials. The present invention provides a calcium-phosphorus compound-magnesium composite coating for bone implants and a preparation method thereof. The bionic deposition method and vapor deposition technology are adopted. Calcium-phosphorus compound-magnesium composite coatings are prepared on titanium and titanium alloys, cobalt-based alloys, and stainless steel to solve the problems of bone activity and infection in existing implant materials. The permanent implant materials obtained by this method are suitable for the mechanical performance requirements of various implant sites. And has excellent biocompatibility, and has bactericidal function at the same time

Method used

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  • Calcium-phosphorus compound-magnesium composite coating for bone implanting and preparation method thereof
  • Calcium-phosphorus compound-magnesium composite coating for bone implanting and preparation method thereof
  • Calcium-phosphorus compound-magnesium composite coating for bone implanting and preparation method thereof

Examples

Experimental program
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Effect test

Embodiment 1

[0034] The flaky pure titanium (Ti) sample was polished to 2000# with sandpaper, and after ultrasonic cleaning with acetone, absolute ethanol and deionized water in sequence, it was placed in a NaOH solution with a concentration of 3mol / L at 80°C for 24h; then the preparation containing NaCl 100mM / L, CaCl 2 3mM / L,NH 4 h 2 PO 4 2mM / L and trishydroxymethylaminomethane (TRIS) 50mM / L solution that has the function of accelerating the deposition of calcium-phosphorus compounds; after the base is heated, the matrix is ​​rinsed with deionized water for three times and then cleaned with an ultrasonic cleaner for 1h, and finally The cleaned substrate was deposited in the above deposition solution at a temperature of 50° C. for 12 hours. Such as figure 2 As shown, the prepared calcium phosphorus coating is mainly tile-shaped and presents a porous surface, and the thickness of the coating is about 20 μm. Its X-ray diffraction spectrum is as Figure 4 As shown in a, the composition...

Embodiment 2

[0036] The substrate sample with the calcium-phosphorus coating prepared by the dried example 1 is placed in the deposition chamber furnace body 1, the pure magnesium block is placed in the target position of the evaporation chamber, and the dried prepared substrate with the calcium-phosphorus coating is placed At a position 300mm away from the evaporation source, vacuumize to 10 -4Below Pa, wash with high-purity argon for at least 3 times to remove air and ensure an oxygen-free environment. The evaporation temperature of pure magnesium is 600°C, the working vacuum is 5Pa, the deposition temperature is set at 150°C, and the deposition time is 0.5h. The magnesium block evaporates into magnesium vapor that diffuses and deposits on the surface of the substrate. After the reaction is completed, it is cooled to room temperature with the furnace. Such as image 3 shown. The deposited metal magnesium coating is composed of large particles of pure magnesium, and there is a certain g...

Embodiment 3

[0038] The flaky pure titanium (Ti) sample was polished to 2000# with sandpaper, and after ultrasonic cleaning with acetone, absolute ethanol and deionized water in sequence, it was placed in a NaOH solution with a concentration of 1mol / L at 80°C for 24h; then the preparation containing NaCl 120mM / L, CaCl 2 3mM / L,NH 4 h 2 PO 4 4mM / L and trishydroxymethylaminomethane (TRIS) 50mM / L solution that has the function of accelerating the deposition of calcium-phosphorus compounds; after the base is heated, the matrix is ​​rinsed with deionized water for three times and then cleaned with an ultrasonic cleaner for 1h, and finally The cleaned substrate is deposited in the above deposition solution at a temperature of 50° C. for 8 hours, and the thickness of the prepared calcium phosphorus coating is about 10 μm. Put the pure magnesium block into the target position of the evaporation chamber, place the dried and prepared substrate with calcium-phosphorus coating at a position 300mm aw...

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Abstract

The invention provides a calcium-phosphorus compound-magnesium composite coating for bone implanting and a preparation method thereof, aiming at solving bone combination and infection of implanted materials. A biomimetic deposition method and an evaporation technology are adopted, and a hydroxyapatite-metal magnesium coating is prepared on titanium and a titanium alloy, a cobalt-based alloy and astainless steel solid body; the thickness of the coating is 6 to 220 microns. By adopting the calcium-phosphorus compound-magnesium composite coating provided by the invention, the compatibility of implanting materials of bones and oral implants can be promoted and the infection problem is easy to solve; the implanting materials prepared by the method have excellent good biocompatibility and meetstandard requirements of mechanical properties of implanted parts; the implanting materials has an effective sterilization function.

Description

technical field [0001] The present invention relates to the field of medical materials, in particular to the field of dental implants, orthopedic fixation after trauma, joint replacement and filling materials for human tissue defects, and antibacterial technology for implant materials, and in particular to a calcium phosphorus compound for bone implants- Magnesium composite coating and preparation method thereof Background technique [0002] Implants such as artificial joints only have a lifespan of 10-15 years due to adverse cell reactions caused by implant loosening and abrasion, which cannot meet the long-term use requirements. Meanwhile, infection remains one of the disastrous postoperative complications of orthopedic implants. Metallic foreign bodies implanted in the body are risk factors for such infections, and a series of in vivo reactions, including the weakening of macrophage function and the passivation of the local immune system, create favorable conditions for ...

Claims

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Application Information

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IPC IPC(8): A61L27/32A61L27/06A61L27/04A61L27/58A61L27/54
CPCA61L27/047A61L27/06A61L27/32A61L27/54A61L27/58A61L2300/102A61L2300/404A61L2300/604
Inventor 刘奕陈澜月杨柯于晓明谭丽丽李铎郑博文
Owner HOSPITAL OF STOMATOLOGY CHINA MEDICAL UNIV
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