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A kind of near-infrared conjugated polymer and its preparation method and application

A conjugated polymer, near-infrared technology, used in drug combinations, pharmaceutical formulations, photodynamic therapy, etc., can solve problems such as poor treatment effect, toxic and side effects, and achieve simple preparation, separation and purification processes, and deep tissue penetration. Depth, the effect of weakening the influence of the detection signal

Active Publication Date: 2020-06-09
NANJING UNIV OF POSTS & TELECOMM
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Traditional tumor treatment methods, such as surgery, chemotherapy, and radiotherapy, are often accompanied by toxic and side effects, and the treatment effect is not good

Method used

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  • A kind of near-infrared conjugated polymer and its preparation method and application
  • A kind of near-infrared conjugated polymer and its preparation method and application
  • A kind of near-infrared conjugated polymer and its preparation method and application

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0037] Example 1: Probe Synthesis

[0038] Step 1, Platinum complex preparation

[0039] Compound Pt1: Preparation of complexes of trans-dichlorobistributylphosphoplatinum

[0040] Add 500mg of potassium chloroplatinite to a round bottom flask, add 20mL of deionized water to dissolve it, then add 0.65mL of tributylphosphine, stir at room temperature for 24h, extract with dichloromethane, concentrate to a certain amount, 180°C It was stirred for 3h, and 456mg of yellow oily liquid was obtained by column chromatography.

[0041] Step 2, preparation of alkyne complex

[0042] Compound 1: Preparation of Intermediate 1:

[0043] Add 0.62g 2,4-dimethylpyrrole and 1.09g 3,4-dioctylbenzaldehyde to a round bottom flask, add 100mL redistilled dichloromethane to dissolve, add 50μL trifluoroacetic acid at room temperature, ice Stir under bath conditions for 1 h, add 0.68 g of dichlorodicyanobenzoquinone, stir for 1 h at room temperature, add 10 mL of triethylamine and 10 mL of boron t...

Embodiment 2

[0065] Example 2: In vitro photothermal test experiment of conjugated polymer

[0066] Configure the conjugated polymer nanoparticles obtained in Example 1, take 2, 5, 10, 20 μg mL respectively -1 in a centrifuge tube, then use 1W cm -2 808nm laser test, such as figure 2 As shown, the test data show that different concentrations of conjugated polymers have different values ​​of temperature rise over time, and the higher the concentration of the polymer, the more the temperature rises.

Embodiment 3

[0067] Example 3: In vitro photostability detection experiment of conjugated polymers

[0068] Configure the conjugated polymer nanoparticles obtained in Example 1, using 1W cm -2 After the 808nm laser was irradiated for 2min, 4min, 6min, 8min, and 10min, the absorption spectra were tested respectively, and the results were as follows image 3 shown. The test data indicates that the absorption intensity does not decrease significantly with time, which indicates that the conjugated polymer has good photostability.

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Abstract

The invention discloses a near infrared conjugated polymer, a preparation method of the near infrared conjugated polymer, and application of the near infrared conjugated polymer to living body imagingand living body tumor treatment. The conjugated polymer is prepared from platinum complexes and alkyne monomers through polymerization. The Pt coupling effect is used for improving the photothermal treatment effect; the photophysical property of the polymers is regulated through a conjugated system, so that the conjugated polymer which has the near infrared ray absorption performance and the goodphotothermal imaging effect and can be used for living mouse tumor treatment is obtained. The conjugated polymer can be used in the technical fields of photodynamics therapy, photothermal therapy, biomarking and detection and the like under the photothermal imaging guidance. The preparation process is simple; the raw materials are cheap and rich; the industrial production is convenient. The structure general formula of the near infrared conjugated polymer is shown in the description.

Description

technical field [0001] The invention relates to the technical field of organic photoelectric materials. It specifically relates to a near-infrared conjugated polymer and its preparation method and application. Background technique [0002] Tumor is a qualitative change of normal cells in a biological body under the long-term effects of many internal factors (including genetics, endocrine disorders, malnutrition, stress, etc.) Formed with the ability to proliferate excessively. The main reason for the low 5-year survival rate of cancer patients is the local invasion and distant metastasis of the tumor. Tumor tissue includes not only tumor cells, but also a large number of tumor stroma and tumor stroma cells. This abnormal proliferation is neither in line with the growth law of normal cells nor in line with physiological needs. The occurrence of tumors seriously threatens human health. Traditional tumor treatment methods, such as surgery, chemotherapy, and radiotherapy, a...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C08G61/12A61K41/00A61P35/00A61K49/00
CPCA61K41/0052A61K41/0057C08G61/122C08G2261/11C08G2261/1424C08G2261/143C08G2261/146C08G2261/18C08G2261/3342C08G2261/354C08G2261/52C08G2261/55
Inventor 赵强刘淑娟李国黄维张享享
Owner NANJING UNIV OF POSTS & TELECOMM
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