Polydopamine-polypyrrole nano composite material as well as preparation method and application thereof

A technology of polypyrrole nanometer and polydopamine, which is applied in the field of biomedical materials, can solve the problems of limited signal amplification series, long-term toxicity of nanoparticles, and difficulty in in vivo application, so as to improve the effect, avoid biodistribution and toxicity, and be good The effect of applying the foreground

Inactive Publication Date: 2018-08-31
FUDAN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The former introduces difficult-to-degrade noble metal nanoparticles, which make the nanoparticles have long-term toxicity in vivo; the main problem of the latter is that the number of signal amplification levels is limited, and it is difficult to realize in vivo application.

Method used

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  • Polydopamine-polypyrrole nano composite material as well as preparation method and application thereof
  • Polydopamine-polypyrrole nano composite material as well as preparation method and application thereof
  • Polydopamine-polypyrrole nano composite material as well as preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0032] Prepare 25 mL of a 0.2% silica nanoparticle solution with a mass concentration of pH=1, add 200 mg of chondroitin sulfate, and stir for 24 hours at room temperature; add 189 mg of dopamine hydrochloride, 70 µL of pyrrole, and stir until dissolved; 0.456 g Ammonium persulfate was dissolved in 5 mL of water, and then the mixture was added dropwise to the silica nanoparticle solution in an ice water bath, kept at low temperature, and reacted overnight. Washed several times with water and ethanol, and dried in vacuum to obtain polypyrrole-polydopamine coated silica nanoparticles (see figure 1 ).

Embodiment 2

[0034] Prepare 25 mL of 0.2% silica nanoparticle solution with a mass concentration of pH=1, add 200 mg of sodium hyaluronate, and stir for 24 hours at room temperature; add 189 mg of dopamine hydrochloride, 70 µL of pyrrole, and stir until dissolved; 0.456 g of ammonium persulfate was dissolved in 5 mL of water, and then the mixture was added dropwise to the silica nanoparticle solution in an ice water bath, kept at low temperature, and reacted overnight. Washing with water and ethanol for several times, and vacuum drying to obtain polypyrrole-polydopamine coated silica nanoparticles.

Embodiment 3

[0036] Prepare 25 mL of 0.2% graphene oxide solution with a mass concentration of pH=1, add 200 mg of sodium hyaluronate, and stir for 24 hours at room temperature; add 189 mg of dopamine hydrochloride, 70 µL of pyrrole, and stir until dissolved; 0.456 g Ammonium persulfate was dissolved in 5ml of water and then the mixed solution was added dropwise to the silica nanoparticle solution in an ice water bath, kept at low temperature, and reacted overnight. Wash several times with water and ethanol, and dry in vacuum to obtain polypyrrole-polydopamine coated graphene oxide nanomaterials (see figure 2 ).

[0037] The following specific experiments were performed to detect the integrated diagnosis and treatment nanoparticles with a core-shell structure prepared in Example 1:

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Abstract

The invention belongs to the technical field of biomedical materials and in particular discloses a polydopamine-polypyrrole nano composite material as well as a preparation method and application thereof. According to the material, a simple one-pot method is implemented, and a polymeric dispersant is adopted to synthesize the polydopamine-polypyrrole nano composite material on the surface of a nano template agent in an aqueous phase system. A polydopamine material and a polypyrrole material are both common photo-thermal treatment reagents and photo-acoustic imaging contrast agents. Compared with single polydopamine and polypyrrole, the polydopamine-polypyrrole composite material coating the surface of nanoparticles has two detection signals of high-raman and high photo-acoustic imaging andhigh photo-thermal conversion efficiency as well, three functions of medicine carrying, multi-mode imaging and treatment can be simultaneously achieved without further chemical modification, and novel diagnosis and treatment integrated nanoparticles can be prepared.

Description

Technical field [0001] The invention belongs to the technical field of biomedical materials, and specifically relates to a nano composite material and a preparation method and application thereof. Background technique [0002] The World Health Organization pointed out in the 2015 Cancer Report that cancer has become the main cause of morbidity and death worldwide, and early detection of tumors can help improve the survival rate of patients. Early detection of tumors is inseparable from accurate and effective imaging. The current clinical and some emerging imaging methods have their own limitations in sensitivity, spatial resolution, specificity, and penetration depth. Therefore, combining the advantages of multiple imaging modes is conducive to obtaining comprehensive histological information, effectively positioning tumors, and realizing early cancer diagnosis. [0003] In recent years, with the development of nanotechnology, people have gradually turned their attention to the ap...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K49/22A61K49/18A61K41/00A61K9/51A61K47/34A61P35/00B82Y5/00B82Y15/00
CPCA61K9/5146A61K41/0052A61K49/1818A61K49/223A61P35/00B82Y5/00B82Y15/00
Inventor 杨宇红林沁睿邵正中
Owner FUDAN UNIV
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