Broad-spectrum lyase derived from salmonella bacteriophage and antibacterial application thereof

A bacteriophage lyase and salmonella technology, which is applied in the field of broad-spectrum lyase and its antibacterial application, can solve the problem of inability to kill gram-positive bacteria and the like, and achieve the effect of significant bactericidal effect
CN108486089AActive Publication Date: 2018-09-04YELLOW SEA FISHERIES RES INST CHINESE ACAD OF FISHERIES SCI +1
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Patent Information

Authority / Receiving Office
CN · China
Current Assignee / Owner
YELLOW SEA FISHERIES RES INST CHINESE ACAD OF FISHERIES SCI
Publication Date
2018-09-04

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Abstract

The invention relates to broad-spectrum lyase derived from salmonella bacteriophage and antibacterial application thereof, and belongs to the technical field of biology. The broad-spectrum lyase is salmonella bacteriophage lyase LysSP1, and the amino acid sequence is SEQ ID NO. 1. After the albumen is subjected to prokaryotic expression and purification, recombination lyase is obtained; the recombination lyase can be cracked into different serological type salmonella, some other gram-negative bacteria and gram-positive bacteria, has a wide lysis spectrum and better bactericidal activity, and can be used for the preparation of antibacterial agents of salmonella and some bacteria.
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Description

technical field

[0001] The invention belongs to the field of biotechnology, and in particular relates to a broad-spectrum lyase derived from Salmonella phage and its antibacterial application. Background technique

[0002] Salmonella (Salmonella) is a kind of Gram-negative bacillus that parasitizes in the intestines of humans and animals, and has similar biochemical reactions and antigenic structures. It is an important food-borne pathogen. Salmonella is mainly transmitted to humans through poultry, meat, milk, eggs, aquatic products, etc. Infection with this bacteria will cause vomiting, diarrhea, fever and other symptoms, and in severe cases, coma or even death. Globally, there are an estimated 93,800,000 gastroenteritis cases and 155,000 deaths each year caused by Salmonella infection, of which about 85% are caused by food transmission. In my country, microbial poisoning incidents caused by Salmonella rank second, but cause the largest number of cases. Therefore, explor...

Claims

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