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Application of metalloporphyrin framework encapsulated carbon quantum dots in detection of copper ions

A metalloporphyrin, carbon quantum dot technology, applied in measurement devices, fluorescence/phosphorescence, instruments, etc., can solve problems such as cell homeostasis disorders, neurodegenerative diseases, etc.

Inactive Publication Date: 2018-09-18
NORTHWEST NORMAL UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, if left unregulated, copper can disrupt cellular homeostasis, leading to severe neurodegenerative diseases
In addition, due to Cu 2+ Widely used in agriculture and industry, the impact of copper pollution and its potential toxicity on humans remains a challenging issue worldwide

Method used

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  • Application of metalloporphyrin framework encapsulated carbon quantum dots in detection of copper ions
  • Application of metalloporphyrin framework encapsulated carbon quantum dots in detection of copper ions
  • Application of metalloporphyrin framework encapsulated carbon quantum dots in detection of copper ions

Examples

Experimental program
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Effect test

Embodiment 1

[0029] Example 1 Synthesis of carbon quantum dot ratiometric fluorescent probes encapsulated by porphyrin MOF

[0030] 1) Synthesis of 5,10,15,20-tetrakis(4-carboxymethylphenyl)porphyrin (TCPP-OMe): freshly distilled pyrrole by vacuum distillation. Add 16.5 g of methyl p-formylbenzoate (0.1 mol) and 100 mL of propionic acid into a 500 mL three-neck round bottom flask, stir rapidly in an oil bath and heat to 128° C. to reflux. Then, a mixed solution of pyrrole and propionic acid (3.1 mL pyrrole, 10 mL propionic acid) was added dropwise within 30 min using a constant pressure dropping funnel. After the addition was complete, the reflux reaction was continued for 1 h. After cooling to room temperature, add 100 mL of absolute ethanol, put it in a refrigerator at -4°C to cool overnight, use a Buchner funnel for suction filtration, wash the filter cake with absolute ethanol to obtain a crude product, and dry it in vacuum at 40°C to obtain Deep purple crystalline solid product, sepa...

Embodiment 2

[0035] Embodiment 2 detects Cu 2+

[0036] First, mix the above-mentioned porphyrin MOF-encapsulated carbon quantum dot aqueous solution with HEPES buffer solution (pH 7.2, 20mM) to prepare a 50mg / L probe solution, and take 2mL of the probe solution in a four-sided transparent quartz cuvette.

[0037] Then add a series of concentrations of copper ion solution to detect different concentrations of Cu 2+ Effect on probe fluorescence signal. The slit width of the fluorescence spectrometer is set to 10nm, the excitation light wavelength is set to 390nm, and the emission peak fluorescence intensity at the wavelengths of 446nm, 654nm and 715nm is detected.

[0038] figure 2 is the fluorescence response of the probe solution to different metal ions. It can be seen that the porphyrin MOF-encapsulated carbon quantum dots have good selectivity to copper ions.

[0039] Cu 2+ The addition of will cause the fluorescence intensity (I) of the porphyrin MOF to weaken, and with Cu 2+ As t...

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Abstract

The invention discloses an application of metalloporphyrin framework encapsulated carbon quantum dots in the detection of copper ions. When the copper ions are detected by fluorometry, the metalloporphyrin framework encapsulated carbon quantum dots are used as a ratio type fluorescent probe. The addition of Cu<2+> causes the weakening of the fluorescence intensity of a metalloporphyrin framework and makes the fluorescence intensity of the carbon quantum dots not change, and the addition of other metal ions does not cause Cu<2+> similar fluorescence change, so the highly-selective fluorescent quantitative detection of the copper ions is realized, and the influences of the concentration and the environment in existing fluorescent probes are overcome.

Description

technical field [0001] The invention relates to the application of carbon quantum dots encapsulated by a metalloporphyrin frame in detecting copper ions. Background technique [0002] Copper is a transition element essential to human health. This element works with certain proteins to produce many enzymes that are essential to life. Copper is also a micronutrient in all known forms of life, where it has functions ranging from bone formation and cellular respiration to connective tissue development. However, if left unregulated, copper can disrupt cellular homeostasis, leading to severe neurodegenerative diseases. In addition, due to Cu 2+ Widely used in agriculture and industry, the impact of copper pollution and its potential toxicity on humans remains a challenging issue worldwide. Therefore, developing a reliable, sensitive and highly selective fluorescent probe to detect copper ion content in water is of great significance for human health and environmental protectio...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G01N21/64C09K11/02C09K11/06C09K11/65
CPCC09K11/02C09K11/06C09K11/65G01N21/6428
Inventor 卢小泉牛琦霞张彩中李学梅张雪红武亚丽陕多亮
Owner NORTHWEST NORMAL UNIVERSITY
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